A5071157557- Multiple Sclerosis Research Studies
- Transcranial Magnetic Stimulation Studies
- Vestibular and auditory disorders
- Stroke Rehabilitation and Recovery
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Peripheral Neuropathies and Disorders
- Treatment of Major Depression
- Pain Management and Treatment
- Functional Brain Connectivity Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Muscle activation and electromyography studies
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Cardiovascular and exercise physiology
- Musculoskeletal pain and rehabilitation
- Attention Deficit Hyperactivity Disorder
- Neural and Behavioral Psychology Studies
- Agricultural and Food Sciences
- Thermoregulation and physiological responses
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Exercise and Physiological Responses
Royal Ottawa Mental Health Centre
2023-2024
University of Ottawa
2023-2024
Université du Québec en Outaouais
2024
Memorial University of Newfoundland
2017-2023
Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso
2015
Background. Paired exercise and cognitive training have the potential to enhance cognition by “priming” brain upregulating neurotrophins. Methods. Two-site randomized controlled trial. Fifty-two patients >6 months poststroke with concerns about impairment trained 50 70 minutes, 3× week for 10 weeks 12-week follow-up. Participants were 1 of 2 physical interventions: Aerobic (>60% VO 2peak using <10% body weight–supported treadmill) or Activity (range movement functional tasks)....
Transcranial magnetic stimulation (TMS) is a non-invasive method used to investigate neurophysiological integrity of the human neuromotor system. We describe in detail, methodology single pulse TMS protocol that was performed large cohort people (n = 110) with multiple sclerosis (MS). The aim establish and validate core-set variables predicted typical MS clinical outcomes: walking speed, hand dexterity, fatigue, cognitive processing speed. provide brief simple methodological pipeline examine...
Abstract Background Aerobic training has the potential to restore function, stimulate brain repair, and reduce inflammation in people with Multiple Sclerosis (MS). However, disability, fatigue, heat sensitivity are major barriers exercise for MS. We aimed determine feasibility of conducting vigorous harness-supported treadmill a room cooled 16 °C (10 weeks; 3times/week) examine longer-term effects on markers among those using ambulatory aids. Methods Ten participants (9 females) aged 29 74...
Background and Purpose: Even a single bout of aerobic exercise (AE) enhances corticospinal excitability (CSE), biomarker neuroplasticity. Because neurodegeneration limits capacity for neuroplasticity, it is not clear whether AE would induce CSE changes in people with progressive multiple sclerosis (MS). Methods: People MS (n = 10) requiring ambulatory assistive devices completed graded maximal test. Dual-energy x-ray absorptiometry was used to quantify body fat lean mass. Before following...
Background: Inflammatory lesions and neurodegeneration lead to motor, cognitive sensory impairments in people with multiple sclerosis (MS). Accumulation of disability is at least partially due diminished capacity for neuroplasticity within the central nervous system. Aerobic exercise a potentially important intervention enhance since it causes upregulation neurotrophins enhances corticospinal excitability which can be probed using single-pulse Transcranial Magnetic Stimulation (TMS). Whether...
To determine whether stroke survivors could maintain workloads during functional task practice that can reach moderate levels of cardiometabolic stress (i.e., ≥40% oxygen uptake reserve ([Formula: see text]O
Objective: Evaluate intensity-dependent effects of a single bout high intensity interval training (HIIT) compared to moderate constant-load exercise (MICE) on corticospinal excitability (CSE) and upper limb performance in chronic stroke. Design: Randomized cross-over trial. Setting: Research laboratory tertiary rehabilitation hospital. Participants: Convenience sample 12 stroke survivors. Outcome measures: Bilateral CSE measures intracortical inhibition facilitation, motor thresholds, evoked...
Persons with multiple sclerosis (MS) frequently report pain that negatively affects their quality of life. Evidence linking and corticospinal excitability in MS is sparse. We aimed to (1) examine differences participants without (2) explore predictors pain.Sixty-four rated severity on a visual analog scale (VAS). Transcranial magnetic stimulation (TMS) validated clinical instruments characterized subjective disease features like mood fatigue. retrieved information participants' prescriptions...
Investigate excitatory-inhibitory (E/I) (im)balance using transcranial magnetic stimulation (TMS) in individuals with Multiple Sclerosis (MS) and determine its validity as a neurophysiological biomarker of disability.
Objective. To develop consensus recommendations for the use of repetitive transcranial magnetic stimulation (rTMS) as an adjunct intervention upper extremity motor recovery in stroke rehabilitation clinical trials. Participants. The Canadian Platform Trials Non-Invasive Brain Stimulation (CanStim) convened a multidisciplinary team clinicians and researchers from institutions across Canada to form CanStim Consensus Expert Working Group. Process. Four themes were identified: (1) patient...
Abstract Background Major depressive disorder (MDD) is a prevalent mental health condition affecting millions worldwide, leading to disability and reduced quality of life. MDD poses global priority due its early onset association with other disabling conditions. Available treatments for exhibit varying effectiveness, substantial portion individuals remain resistant treatment. Repetitive transcranial magnetic stimulation (rTMS), applied the left and/or right dorsolateral prefrontal cortex...
Background Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease that involves attacks of inflammatory demyelination and axonal damage, with variable but continuous disability accumulation. Transcranial magnetic stimulation (TMS) a noninvasive method to characterize conduction loss damage in the corticospinal tract. TMS as technique provides indices tract function may serve putative MS biomarkers. To date, no reviews have directly addressed diagnostic performance MS. The...
Abstract Introduction Sleep disturbances are commonly observed in individuals with depression, and associated severity of treatment outcomes, risk relapse. Repetitive transcranial magnetic stimulation, including newer optimized theta-burst stimulation (TBS) protocols, is recognized as a safe effective intervention for treatment-resistant depression (TRD). Presently, little known about the impact TBS treatments on sleep depression. We examined changes subjective TRD receiving daily...
Moderate-intensity aerobic exercise training is an important treatment strategy to enhance functional recovery and decrease cardiometabolic risk factors after stroke. However, stroke related impairments limit access ergometer-type exercise. The aims of the current study were (1) evaluate whether our task-oriented circuit protocol (intermittent training; IFT) could be used sustain moderate-intensity workloads over a 10-week intervention period, (2) investigate its preliminary effects on...