A5007345460- Multiple Sclerosis Research Studies
- Hearing Loss and Rehabilitation
- Olfactory and Sensory Function Studies
- Effects of Vibration on Health
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Memory Processes and Influences
- Cancer-related cognitive impairment studies
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Traumatic Brain Injury Research
- Diabetes Management and Research
- Memory and Neural Mechanisms
- Stroke Rehabilitation and Recovery
- Brain Tumor Detection and Classification
- Neuroinflammation and Neurodegeneration Mechanisms
- Fatty Acid Research and Health
- Resilience and Mental Health
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Brain Metastases and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Sleep and related disorders
- Musicians’ Health and Performance
University of Ottawa
2016-2025
Ottawa Hospital
2016-2025
Ottawa Hospital Research Institute
2016-2025
MIND Research Institute
2023-2024
uOttawa Brain and Mind Research Institute
2016-2024
Carleton University
2016-2024
Deleted Institution
2023
University of Manitoba
2022
University of Warwick
2022
Ontario Brain Institute
2016-2017
The ability of a newly developed measure information processing to detect deficits in cognitive functioning associated with multiple sclerosis (MS) was investigated. Computerized Tests Information Processing (CTIP; Tombaugh, T., & Rees, L. (1999). (CTIP). Unpublished test. Ottawa, Ontario, Canada: Carleton University) administered 60 clinically definite MS patients and healthy controls. responded significantly slower than controls on the reaction time tests composing CTIP. Moreover, as CTIP...
The protective effect of cognitive reserve (CR) on cognition in people with multiple sclerosis (PwMS) has been well described.To explore the relationship between aspects CR, namely, leisure pursuits and depression.In a cross-sectional study, sample 155 PwMS 115 healthy controls (HC) underwent testing Minimal Assessment Cognitive Function Multiple Sclerosis (MACFIMS) battery. Leisure activity was retrospectively recorded using Activity Scale (LAS). Depression assessed Hospital Anxiety...
AbstractThe oral Symbol Digit Modalities Test (SDMT) has been recommended to assess cognition for multiple sclerosis (MS) patients. However, the lack of adequate normative data limited its clinical utility. Recently published regression-based norms may resolve this limitation but, because these were derived from a relatively small sample, their stability is unclear. We aimed evaluate SDMT by comparing existing cross-validation dataset. First, created similarly-sized, independent, control...
Abstract Objective Accelerated brain volume loss has been noted following immunoablative autologous hematopoietic stem cell transplantation (IAHSCT) for multiple sclerosis. As with other MS treatments, this is often interpreted as ‘pseudoatrophy’, related to reduced inflammation. Treatment‐related neurotoxicity may be contributory . We sought objective evidence of post‐IAHSCT toxicity by quantifying levels Neurofilament Light Chain (sNfL) and Glial Fibrillary Acidic Protein (sGFAP) before...
Objective To compare the ability of Computerized Test Information Processing (CTIP) to detect impaired cognitive processing speed in patients with multiple sclerosis (MS) a traditional 3.0 second Paced Auditory Serial Addition (PASAT) and Adjusting-PASAT which allows for calculation score. Background A primary deficit MS is an process information quickly. Unfortunately, relatively few clinical tests effectively measure speed. Of these, PASAT generally acknowledged be most sensitive, but use...
Abstract Objective: The Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) is a consensus-based collection neuropsychological tests that evaluate cognitive functioning individuals with multiple sclerosis (MS). are typically scored using each respective published test manual, leaving the examiner to make interpretations from norms derived different American populations. Given demographic differences, this may lead misinterpretation findings Canadians. Our goal was...
Background: Cognitive fatigue can be objectively measured on tasks of sustained attention and defined as decreased performance a result cognitive effort. Individuals with multiple sclerosis (MS) early in their disease are vulnerable to fatigue, although this has yet evaluated longitudinally. We aimed evaluate over 3-year interval individuals early-phase relapsing-remitting MS (RRMS). The sensitivity the Paced Auditory Serial Addition Test (PASAT) at detecting was evaluated, impact scoring...
Background Concussion in children and adolescents is a significant public health concern, with 30% to 35% of patients at risk for prolonged emotional, cognitive, sleep, or physical symptoms. These symptoms negatively impact child’s quality life while interfering their participation important neurodevelopmental activities such as schoolwork, socializing, sports. Early psychological intervention following concussion may improve the ability regulate emotions adapt postinjury symptoms, resulting...
Cognitive fatigue (CF) can be defined as decreased performance with sustained cognitive effort. The present study examined the interrelatedness of disease severity, fatigue, depression, and sleep quality in order to evaluate their predictive roles CF MS. Four theoretical models examining these variables were assessed.Fifty-eight individuals a diagnosis MS recruited. was measured by last third versus first on Paced Auditory Serial Addition Test (PASAT). PASAT self-report measures...
Reduction in information processing speed (IPS) is a key deficit multiple sclerosis (MS). The Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities (SDMT), and Computerized of Information Processing (CTIP) are used to measure IPS. Both the PASAT SDMT sensitive deficits CTIP, newer task, also shows promise. has several limitations, it often perceived negatively by patients. Yet little supporting quantitative evidence such perceptions been presented. Therefore, this study,...
Normal aging holds negative consequences for memory, in particular the ability to recollect precise details of an experience. With this mind, Jennings and Jacoby (2003) developed a recollection training method using single-probe recognition memory paradigm which new items (i.e., foils) were repeated during test phase at increasingly long intervals. In previous reports, has appeared improve older adults' performance on several non-trained cognitive tasks. We aimed further examine potential...
Abstract The Relative Consequence Model proposes multiple sclerosis (MS) patients have a fundamental deficit in processing speed that compromises other cognitive functions. present study examined the mediating role of speed, as well working memory, MS-related effects on functions for early relapsing-remitting patients. Seventy MS with disease duration not greater than 10 years and 72 controls completed tasks assessing learning, executive functioning. possible roles memory were evaluated...
Cognitive dysfunction in multiple sclerosis (MS) causes numerous limitations activities of daily living.To develop an improved method cognitive assessment people with MS using novel real-world distracters.A sample 99 and 55 demographically matched healthy controls underwent testing the Minimal Assessment Functioning Multiple Sclerosis (MACFIMS) a modified version computerized Symbol Digit Modalities Test (c-SDMT). Half subjects completed c-SDMT built-in distracters half without.The mean time...
The service configuration with distinct child and adolescent mental health services (CAMHS) adult (AMHS) may be a barrier to continuity of care. Because lack transition policy, CAMHS clinicians have decide whether when young person should AMHS. This study describes which characteristics are associated the clinicians' advice continue treatment at AMHS.Demographic, family, clinical, treatment, service-use MILESTONE cohort 763 people from 39 in Europe were assessed using multi-informant...
F.D. exhibited the cognitive and behavioral profile of frontotemporal dementia in context spontaneous intracranial hypotension (SIH). Symptoms included orthostatic headache, as well personality changes. He underwent CT, EEG, MRI neuropsychological evaluations before after corticosteroid treatment. The initial evaluation documented significant impairment with a predominance executive dysfunction. Following treatment, second revealed marked improvement cognition behavior. Rapid diagnosis...