Although memory impairment is the main symptom of Alzheimer's disease (AD), language can be an important marker. Relatively few studies in AD quantify impairments connected speech using computational techniques.We aim to demonstrate state-of-the-art accuracy automatically identifying from short narrative samples elicited with a picture description task, and uncover salient linguistic factors statistical factor analysis.Data are derived DementiaBank corpus, which 167 patients diagnosed...

Studies of working memory load effects on human EEG power have indicated divergent in different frequency bands. Although gamma typically increases with load, the dependency lower theta and alpha bands is uncertain. We obtained intracranial electroencephalography measurements from 1453 electrode sites 14 epilepsy patients performing a Sternberg task, order to characterize anatomical distribution load-related changes across spectrum. Gamma occurred throughout brain, but were most common...

EEG studies employing time-frequency analysis have revealed changes in theta and alpha power a variety of language memory tasks. Semantic syntactic violations embedded sentences evoke well-known ERPs, but little is known about the oscillatory responses to these violations. We investigated both kinds violations, while monolingual bilingual participants performed an acceptability judgment task. Both elicited decreases (event-related desynchronization, ERD) 8-30 Hz frequency range, with...

Introduction:Telerehabilitation has been promoted as a more efficient means of delivering rehabilitation services to stroke patients while also providing care options those unable attend conventional therapy. However, the application telerehabilitation interventions in populations proven be challenging than anticipated, with many studies showing mixed results terms its efficacy. Six different clinical trials examining were initiated across Canada part Heart and Stroke Foundation's 2013...

Complex memory of personal events is thought to depend on coordinated reinstatement cortical representations by the medial temporal lobes (MTL). MTL-cortical theta and gamma coupling believed mediate such coordination, but which structures are critical for retrieval how they influence oscillatory unclear. We used magnetoencephalography (MEG) combined with continuous burst stimulation (cTBS) (i) clarify roles oscillations in network-wide communication during naturalistic retrieval, (ii)...

Broca's area is preferentially activated by reversible sentences with complex syntax, but various linguistic factors may be responsible for this finding, including syntactic movement, working-memory demands, and post hoc reanalysis. To distinguish between these, we tested the interaction of complexity semantic reversibility in a functional magnetic resonance imaging study sentence–picture matching. During auditory comprehension, induced selective activation throughout left perisylvian...

Spontaneous signals in neuroimaging data may provide information on cortical health disease and aging, but the relative sensitivity of different approaches is unknown. In present study, we compared complementary indicators neural dynamics resting-state MEG BOLD fMRI, their relationship with blood flow. Participants included patients post-stroke aphasia, age-matched controls, young adults. The complexity brain activity at rest was quantified using spectral analysis multiscale entropy (MSE)...

Abstract We used functional magnetic resonance imaging to test the hypothesis that nature of neural response taste varies as a function task subject is asked perform. Subjects received sweet, sour, salty and tasteless solutions passively while evaluating stimulus presence, pleasantness identity. Within insula overlying operculum location maximal vs. varied task; however, primary cortex (anterior dorsal insula/frontal – AIFO), well more ventral region anterior insula, responded irrespective...

Background: Telerehabilitation promises to greatly expand access of underserved populations speech therapy, but concerns remain about the effectiveness services delivered remotely compared in-person treatment.Aims: To evaluate telerehabilitation, we conducted a randomized non-inferiority trial for chronic poststroke communication disorders, testing whether equivalent gains can be expected from vs. telerehabilitative clinical service delivery, with both groups completing homework exercises...

Bilingualism has been linked to improved executive function and delayed onset of dementia, but it is unknown whether similar benefits can be obtained later in life through deliberate intervention. Given the logistical hurdles second language acquisition a randomized trial for older adults, few interventional studies have done thus far. However, recently developed smartphone apps offer convenient means acquire skills compared with brain training specifically designed improve function. In...

Differential patterns of white matter disruption have recently been reported in the non-fluent (nfvPPA) and semantic (svPPA) variants primary progressive aphasia (PPA). No single measure is sufficient to distinguish between PPA variants, but connected speech allows for quantification multiple measures. The aim present study was further investigate correlates associated with features PPA. We examined relationship metrics deficits using an automated analysis transcriptions diffusion tensor...

Abstract Using magnetoencephalography, we investigated the potential of perilesional and contralesional activity to support language recovery in patients with poststroke aphasia. In healthy young controls, left‐lateralized ventral frontotemporal regions responded semantic anomalies during sentence comprehension bilateral dorsal frontoparietal syntactic anomalies. Older adults showed more extensive responses less lateralized anomalies, decreased activation left occipital parietal for both...

Abstract Recent findings indicate that measures derived from resting-state magnetoencephalography (rsMEG) are sensitive to cortical dysfunction in post-stroke aphasia. Spectral power and multiscale entropy (MSE) show left-hemispheric areas surrounding the stroke lesion (perilesional) exhibit pathological oscillatory slowing alterations signal complexity. In current study, we tested whether individually-targeted high-definition transcranial direct stimulation (HD-tDCS) can reduce MEG...

A major barrier to acceptance of psi is that effects are small and hard replicate. To address this issue, we developed a novel neurobiological model study controversial phenomenon based upon the concept brain may act as psi-inhibitory filter. Our previous research in individuals with frontal lobe damage suggests filter includes left medial middle region. We report our findings healthy participants rTMS induced reversible lesions. In support priori hypothesis, found significant effect...

Blink-related oscillations (BROs) are newly discovered neurophysiological brainwave responses associated with spontaneous blinking, and represent environmental monitoring awareness processes as the brain evaluates new visual information appearing after eye re-opening. BRO have been demonstrated in healthy young adults across multiple task states modulated by both factors, but little is known about this phenomenon aging. To address this, we undertook first large-scale evaluation of aging...

Post-stroke impairment is associated not only with structural lesions, but also dysfunction in surviving perilesional tissue. Previous studies using equivalent current dipole source localization of MEG/EEG signals have demonstrated a preponderance slow-wave activity localized to areas. Recent the utility nonlinear analyses such as multiscale entropy (MSE) for quantifying neuronal wide range pathologies. The study utilized beamformer-based reconstruction space compare spectral and measures...

Recent models of hippocampal function have emphasized its role in relational binding – the ability to form lasting representations regarding relations among distinct elements or items which can support memory performance, even over brief delays (e.g., several seconds). The present study examined extent aging is associated with changes recruitment oscillatory activity within and neocortical regions performance on a short delay visuospatial task. Structural magnetic resonance imaging MEG were...