Diane Havard
A5018252886- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Electron Spin Resonance Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Stroke Rehabilitation and Recovery
- Cardiac and Coronary Surgery Techniques
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Cardiac Ischemia and Reperfusion
- Pediatric health and respiratory diseases
- Atrial Fibrillation Management and Outcomes
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Esophageal and GI Pathology
- Venous Thromboembolism Diagnosis and Management
University of Nottingham
2016-2023
Campbell Collaboration
2021
BackgroundIntensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive (combined aspirin, clopidogrel, dipyridamole) that guideline-based therapy.MethodsWe did an international, prospective, randomised, open-label, blinded-endpoint trial adult participants ischaemic stroke or transient attack (TIA) within 48 h onset. Participants...
The risk of death from spontaneous intracerebral haemorrhage is increased for people taking antiplatelet drugs. We aimed to assess the feasibility randomising patients on drug therapy with desmopressin or placebo reduce effect.
Rationale Vascular nitric oxide levels are low in acute stroke and donors such as glyceryl trinitrate have shown promise when administered very early after stroke. Potential mechanisms of action include augmentation cerebral reperfusion, thrombolysis thrombectomy, lowering blood pressure, cytoprotection. Aim To test the safety efficacy four days transdermal (5 mg/day) versus sham patients with ultra-acute presumed who recruited by paramedics prior to hospital presentation. Sample size...
Two antiplatelet agents are better than one for preventing recurrent stroke after acute ischaemic or transient attack (TIA). Therefore, intensive treatment with three might be still, providing it does not cause undue bleeding. To compare the safety and efficacy of therapy guideline TIA. International prospective randomised open-label blinded end-point parallel-group superiority clinical trial. Acute hospitals at 106 sites in four countries. Patients > 50 years age non-cardioembolic TIA...