A5043702068- Cardiovascular Function and Risk Factors
- Global Health Care Issues
- Advanced MRI Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Healthcare Systems and Reforms
- Global Maternal and Child Health
- Diet and metabolism studies
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cell death mechanisms and regulation
- Health and Conflict Studies
- Cardiac Imaging and Diagnostics
- Health disparities and outcomes
- Cancer Mechanisms and Therapy
- Pancreatic function and diabetes
- Metabolism and Genetic Disorders
- Cardiac Ischemia and Reperfusion
- Diet, Metabolism, and Disease
- Streptococcal Infections and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Global Public Health Policies and Epidemiology
- RNA regulation and disease
University of Alberta
2020-2025
Mekelle University
2015-2021
Figshare (United Kingdom)
2017
Deakin University
2017
Seattle University
2017
The burden of cardiovascular diseases (CVDs) remains unclear in many regions the world. GBD (Global Burden Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for burden. CVD was estimated from vital registration verbal autopsy data. prevalence using modeling software health surveys, prospective cohorts, system administrative data, registries. Years lived with disability (YLD) were by multiplying weights. life lost...
Glycemic control in diabetes mellitus is a cornerstone reducing morbidity and mortality of the disease. Achieving glycemic or hyperglycemia significantly decreases microvascular macrovascular complications diabetes. Even though measurement glycated hemoglobin (HbA1c) remains gold standard for assessment control, there no consensus whether fasting postprandial plasma glucose (PPG) better predictor resource-poor settings when HbA1c not available. The aim this systematic review meta-analysis...
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a prevalent disease worldwide. While it well established that alterations of cardiac energy metabolism contribute to cardiovascular pathology, the precise source fuel used by heart in HFpEF remains unclear. The objective this study was define metabolic profile HFpEF. Methods and results Eight-week-old C57BL/6 male mice were subjected ‘2-Hit’ protocol [60% high-fat diet (HFD) + 0.5 g/L Nω-nitro-L-arginine methyl ester]....
Abstract High rates of cardiac fatty acid oxidation during reperfusion ischemic hearts contribute to contractile dysfunction. This study aimed investigate whether lysine acetylation affects and recovery in post-ischemic hearts. Isolated working from Sprague Dawley rats were perfused with 1.2 mM palmitate 5 glucose subjected 30 min ischemia 40 reperfusion. Cardiac function, oxidation, glycolysis compared between pre- The status enzymes involved energy metabolism was assessed both groups....
Introduction Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and heart disease (RHD). Uncertainties regarding inter-ethnic preparation variability, target exposure profiles BPG injection key knowledge gaps for RHD control. Methods To evaluate pharmacokinetics (PK) in patients receiving 4-weekly doses Ethiopia, we conducted prospective cohort study ARF/RHD attending cardiology outpatient clinics. Serum...
Introduction: There is considerable confusion as to what changes in cardiac energy metabolism occur heart failure with preserved ejection fraction (HFpEF). In HFpEF mice hearts, we found a marked decrease glucose oxidation, which accompanied by an increase fatty acid oxidation. Ketones have been proposed extra source of fuel for the failing, heart, although it remains unclear if ketones may adversely affect and Methods: 13-month-old C57BL/6N female were administered 60% high-fat diet L-NAME...
Introduction: Myocardial glycolysis increases in hypertrophic and failing hearts. Hyperacetylation also occurs the heart, many glycolytic enzymes are known to be subject acetylation. However, it is generally considered that acetylation has inhibitory effects on glycolysis. As a result, not clear whether changes directly contribute cardiac hypertrophy. We therefore determined of activity cytosolic deacetylase SIRT2 regulate Methods: Glycolysis rates were measured rat heart-derived H9c2...