A5028981670- Cardiovascular Function and Risk Factors
- ATP Synthase and ATPases Research
- RNA regulation and disease
- Advanced Breast Cancer Therapies
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Ocular Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Anesthesia and Neurotoxicity Research
- Head and Neck Surgical Oncology
- Spaceflight effects on biology
- Heart Failure Treatment and Management
- Cancer Cells and Metastasis
- Cardiovascular and exercise physiology
- Ocular Diseases and Behçet’s Syndrome
- Adipose Tissue and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- HER2/EGFR in Cancer Research
University of Alberta
2021-2024
Ankara University
2023
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a prevalent disease worldwide. While it well established that alterations of cardiac energy metabolism contribute to cardiovascular pathology, the precise source fuel used by heart in HFpEF remains unclear. The objective this study was define metabolic profile HFpEF. Methods and results Eight-week-old C57BL/6 male mice were subjected ‘2-Hit’ protocol [60% high-fat diet (HFD) + 0.5 g/L Nω-nitro-L-arginine methyl ester]....
Heart failure with preserved ejection fraction (HFpEF) is a major health problem limited treatment options. Although optimizing cardiac energy metabolism potential approach to treating heart failure, it poorly understood what alterations in actually occur HFpEF. To determine this, we used mice which HFpEF was induced using an obesity and hypertension protocol for 10 weeks. Next, carvedilol, third-generation <i>β</i>-blocker biased agonist that exhibits agonist-like effects through <i>β</i>...
Abstract Invasive breast cancer (BrCa) is predicted to affect 1 in 9 women a lifetime;1 32 will die from this disease. The most aggressive forms of BrCa, basal-like/triple-negative phenotype (TNBC), are challenging treat and result higher mortality due high number metastatic cases. There paucity options for TNBC treatment, which highlights the need additional innovative treatment approaches. NIH-III mice were injected abdominal mammary fat pad with luciferase-expressing derivative human cell...
Introduction: Myocardial glycolysis increases in hypertrophic and failing hearts. Hyperacetylation also occurs the heart, many glycolytic enzymes are known to be subject acetylation. However, it is generally considered that acetylation has inhibitory effects on glycolysis. As a result, not clear whether changes directly contribute cardiac hypertrophy. We therefore determined of activity cytosolic deacetylase SIRT2 regulate Methods: Glycolysis rates were measured rat heart-derived H9c2...