A5058452902- Congenital Heart Disease Studies
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Tracheal and airway disorders
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Vascular anomalies and interventions
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Coronary Artery Anomalies
- Birth, Development, and Health
- Aortic Disease and Treatment Approaches
- Pregnancy and preeclampsia studies
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Gastroesophageal reflux and treatments
- Maternal and Neonatal Healthcare
- Atrial Fibrillation Management and Outcomes
- Health disparities and outcomes
- Vasculitis and related conditions
Women's & Children's Health Research Institute
2023-2024
University of Alberta
2013-2024
Women and Children’s Health Research Institute
2018-2024
Stollery Children's Hospital
2013-2024
Alberta Hospital Edmonton
2013-2021
John Wiley & Sons (United Kingdom)
2021
Hudson Institute
2021
University of Calgary
2021
Children’s Health Research Institute
2017-2020
Freeman Hospital
2010-2017
Prenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic geographic factors PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race ethnicity, rural residence, distance residence (distance driving time from a cardiac surgical center) are associated or timing PND, secondary aim to analyze differences...
Background Distances between delivery and cardiac services can make the care of fetuses with disease at risk acute cardiorespiratory instability birth a challenge. In 2013 we implemented fetal echocardiography‐based algorithm targeting considered high for ≤2 hours in our pediatric operating room children's hospital, and, herein, examine experience. Methods Results We reviewed maternal postnatal medical records all encountered January to March 2022 instability. Secondary analysis was...
ace and ethnicity, socioeconomic status (SES), geography have been associated with differential outcomes in congenital heart disease death.In patients hypoplastic left syndrome (HLHS), lower SES has increased complications 1-year survival. 1o previous study examined how sociodemographics affect neonatal death among prenatally diagnosed HLHS.The goal was to investigate infants a prenatal diagnosis of HLHS understand associations between maternal patient characteristics hospital discharge...
The aims of this study were to ascertain the effect a regional training program in fetal echocardiography for obstetric radiographers on antenatal detection major congenital heart disease (CHD) and document short-term outcomes CHD.All 87 Northern Ireland invited attend 2.5 days during 1-year period. Data collected before after training, over 5-year period, assess CHD population.The rose significantly, from 28% (72/262) pretraining 43% (36/84) year (P = 0.008). Antenatal diagnosis...
To determine the antenatal detection rate in Northern Ireland (NI) for major congenital heart disease (CHD) between 1st January 2002 and 31st December 2006. compare characteristics prognosis of versus postnatal groups.Data were obtained from fetal, neonatal post-mortem records. Variables recorded: diagnosis, karyotype, referral indication, type defect outcome.Twenty-seven per cent (73/272) patients with CHD diagnosed antenatally. Forty-one (30/73) these died before 28 days. Eighty-two...
To document changes in the normal embryonic/fetal cardiac axis late first and early second trimesters of pregnancy.Images from 188 fetal echocardiograms performed prospectively between 8 15 weeks' gestation 166 healthy pregnancies 10 with severe heart disease were reviewed. For each echocardiogram, three measurements taken axial plane at level four-chamber view. Differences mean different gestational ages compared.The ± SD was 25.5 11.5° + 0 to 9 6 weeks (Group 1), 40.4 9.2° 11 2), 49.2 7.4°...
ABSTRACT Objectives The association between pregestational diabetes mellitus (PDM) and risk of congenital heart disease (CHD) is well recognized; however, the importance glycemic control other coexisting factors during pregnancy less clear. We sought to determine relative (RR) major CHD (mCHD) among offspring from pregnancies complicated by PDM effect first‐trimester on mCHD risk. Methods determined incidence (requiring surgery within 1 year birth or resulting in termination fetal demise)...
There is increasing demand for accurate early fetal cardiac disease (FCD). We assessed the accuracy of echo (EFE) conducted in our high-volume program and reviewed spectrum FCD, associated genetic anomalies, outcomes encountered.
The perinatal transition is characterized by acute changes in cardiac loading. Compared with normal newborn combined output (CCO), single right ventricular (RV) of neonates hypoplastic left heart syndrome (HLHS) markedly greater. aim this study was to examine the mechanisms adaptation that facilitate from late fetal early neonatal life HLHS.
During perinatal transition in hypoplastic left heart syndrome (HLHS), reduced systemic blood flow (Qs) and cerebral increased pulmonary (Qp) are observed, contributing to hemodynamic instability. The aim of the present study was explore whether similar or discordant changes occur critical outflow tract obstruction (POFO) compared with HLHS healthy control subjects.
Past studies of fetal tetralogy fallot (ToF) have reported extra-cardiac anomalies (ECAs) in 17%-45%, genetic syndromes as low 20% and poor postnatal outcomes. This study sought to examine these factors a contemporary cohort.A retrospective review examining 83 fetuses with ToF diagnosed 2012-2019. Referral indication, subtype, additional cardiac, diagnoses, pregnancy outcomes survival were documented.The mean gestational age at diagnosis was 23 ± 4 weeks. Of 94% (78/83) testing (GT), 30%...
To document the clinical spectrum and outcomes of fetal double outlet right ventricle (DORV) without heterotaxy in a recent diagnostic era.Prenatal cases DORV consecutively diagnosed from 2007 to 2018 were retrospectively identified. Clinical records, including details regarding genetic testing pre postnatal imaging reviewed.DORV was 99 fetuses heterotaxy. The most common anatomic subtype subaortic ventricular septal defect (VSD) normally related great arteries with (n = 45, 45%) or 13, 13%)...
Ductus arteriosus (DA)-related branch pulmonary stenosis (PS), due to ductal tissue migration into the proximal artery (PA) ipsilateral DA, is common in newborns with atresia (PAtr) and contributes significantly their mortality morbidity. We sought define fetal echocardiographic predictors of DA-PS PAtr.This was a study all neonates diagnosed prenatally PAtr DA-dependent circulation, DA that joined underbelly arch, who had undergone surgical or catheter intervention our hospital between 2009...
Objectives To describe a novel strategy for the management of infants with hypoplastic left heart syndrome (HLHS) and intact atrial septum. Antenatally diagnosed are delivered in cardiac theatre immediate decompression (LAD) using hybrid transatrial stent insertion (HTSI) via sternotomy is carried out. Background HLHS septum condition incompatible life following placental separation. Despite number reported strategies survival these remains much worse than those born an adequate...
Fetal/neonatal alloimmune thrombocytopenia (FNAIT) can be a cause of severe fetal thrombocytopenia, with the common presentation being intracranial hemorrhage in fetus, usually third trimester. A very unusual case anemia progressed to hydrops. This was further complicated by maternal Mirror syndrome and human chorionic gonadotropin-induced thyrotoxicosis. Without knowledge etiology, possibly due associated cardiac dysfunction, transfusion resulted demise. Subsequent testing revealed FNAIT as...