A5046730713- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Fuel Cells and Related Materials
- Birth, Development, and Health
- Cardiac electrophysiology and arrhythmias
- Prenatal Screening and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Elasticity and Material Modeling
- Cardiac pacing and defibrillation studies
- Organ Transplantation Techniques and Outcomes
- Gestational Diabetes Research and Management
- Coronary Artery Anomalies
- Cardiomyopathy and Myosin Studies
- Infant Development and Preterm Care
- Cardiovascular Health and Disease Prevention
- Child and Adolescent Health
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
University of Alberta
2017-2025
Boston Children's Hospital
2025
Stollery Children's Hospital
2017-2024
Women and Children’s Health Research Institute
2022
SickKids Foundation
2017
The current standard method for organ preservation (cold storage, CS), exposes the heart to a period of cold ischemia that limits safe time and increases risk adverse post-transplantation outcomes. Moreover, static nature CS does not allow evaluation or intervention during interval. Normothermic ex situ perfusion (ESHP) is novel donated minimizes by providing oxygenated, nutrient-rich perfusate heart. ESHP has been shown be non-inferior in standard-criteria donor hearts also facilitated...
Fetuses of diabetic mothers develop left ventricular (LV) hypertrophy and are at increased long-term risk cardiovascular disease. In our previous longitudinal study from midgestation to late infancy we showed persistence LV aortic stiffness compared with infants healthy mothers, the latter which correlated third trimester maternal hemoglobin A1c. present study, reexamined same cohort in early childhood determine if these abnormalities persisted.Height, weight, right arm blood pressure were...
The perinatal transition is characterized by acute changes in cardiac loading. Compared with normal newborn combined output (CCO), single right ventricular (RV) of neonates hypoplastic left heart syndrome (HLHS) markedly greater. aim this study was to examine the mechanisms adaptation that facilitate from late fetal early neonatal life HLHS.
Past studies of fetal tetralogy fallot (ToF) have reported extra-cardiac anomalies (ECAs) in 17%-45%, genetic syndromes as low 20% and poor postnatal outcomes. This study sought to examine these factors a contemporary cohort.A retrospective review examining 83 fetuses with ToF diagnosed 2012-2019. Referral indication, subtype, additional cardiac, diagnoses, pregnancy outcomes survival were documented.The mean gestational age at diagnosis was 23 ± 4 weeks. Of 94% (78/83) testing (GT), 30%...
Abstract The double-orifice tricuspid valve (DOTV) is a rare lesion. We present series of three patients encountered at the Stollery Children’s Hospital with diagnosis DOTV on 2D and/or 3D echocardiography. patient’s medical records are reviewed for presentation history, investigative findings, and clinical course. discuss cases in context complete review all literature documenting DOTV. In majority cases, lesion relatively benign, little change function over short to medium term, outcomes...
Donor heart machine perfusion enables avoidance of prolonged cold ischemia, however the optimal temperature is yet to be elucidated. Given that maintenance beyond ambient levels demands significant energy, we sought determine suitability room-temperature preservation neonatal/pediatric-sized (5-20 kg) piglet donor hearts. A custom device was fabricated suitable for this purpose, with continuous readout pressure, flow rate, temperature, and oxygen saturation. Oxygen delivery automated keep...
Heart conditions in which the tricuspid valve (TV) faces either increased volume or pressure stressors are associated with premature failure. Mechanistic studies to improve our understanding of underlying pathophysiology responsible for development TV failure lacking. Due inability conduct these humans, an animal model is required. In this manuscript, we describe protocols a novel chronic recovery infant piglet heart study changes when placed under combined and stress. model, loading right...
Background Children with a Fontan operation represent unique form of congenital heart disease (CHD) that requires multiple cardiac surgeries and procedures an uncertain long-term outcome. Given the rarity types CHD require this procedure, many children do not know any others like them. Methods With cancelation medically supervised camps due to COVID-19 pandemic, we have organized several physician-led virtual day for connect in their province across Canada. The aim study was describe...
Introduction: Historically, prenatal detection of tetralogy Fallot (ToF) was poor and around 60% had major extracardiac (ECA) or genetic anomalies. Recently, ToF has improved, along with a wider range testing options. Knowledge outcomes risk associated anomalies is crucial for counselling. We hypothesize that now different profile ECAs than previously reported. Methods: A retrospective study all fetuses diagnosis in our Fetal Cardiology program from 2012-2019. type double outlet right...
Heart conditions in which the tricuspid valve (TV) faces either increased volume or pressure stressors are associated with premature failure. Mechanistic studies to improve our understanding of underlying pathophysiology responsible for development TV failure lacking. Due inability conduct these humans, an animal model is required. In this manuscript, we describe protocols a novel chronic recovery infant piglet heart study changes when placed under combined and stress. model, loading right...
Introduction: Tricuspid valve (TV) regurgitation in Hypoplastic Left Heart Syndrome (HLHS) increases the risk of death/transplantation by 2 to 3 times. Abnormalities TV annular shape, leaflets expansion and subvalve apparatus position, have been associated HLHS with subsequent tricuspid (TR). As morphological variation is increasingly recognized, its role on function remains unknown. This study aims describe examine relationship between leaflet morphologies association repair. Methods: Cross...
Background: Up to 15% of patients with partial Atrioventricular Septal Defects ( p AVSD) require re-repair the Left AtrioVentricular Valve (LAVV), 30% having significant regurgitation. Previous qualitative studies suggest abnormalities in papillary muscles, shortened chordae and thick chords as features associated LAVVR. We aim quantitatively assess sub valvar apparatus pAVSD using three-Dimensional Echocardiography (3DE) for its association Hypothesis: hypothesize that larger muscle chordal...