A5017863802- Cardiac Ischemia and Reperfusion
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Photosynthetic Processes and Mechanisms
- Developmental Biology and Gene Regulation
- Fuel Cells and Related Materials
- Neurogenesis and neuroplasticity mechanisms
- Organ Transplantation Techniques and Outcomes
- Pluripotent Stem Cells Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Hippo pathway signaling and YAP/TAZ
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Cardiovascular and Diving-Related Complications
- Cancer-related gene regulation
- Congenital heart defects research
- Nitrogen and Sulfur Effects on Brassica
- Pharmacovigilance and Adverse Drug Reactions
University of Alberta
2017-2024
Nanjing University of Chinese Medicine
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Shaoxing Second Hospital
2024
Qingdao University
2021-2024
Affiliated Hospital of Qingdao University
2021-2024
Alberta Biodiversity Monitoring Institute
2021
Shanxi Agricultural University
2018-2020
Asymmetric stem cell division balances maintenance of the pool and generation diverse types by simultaneously allowing one daughter progeny to maintain a fate its sibling acquire progenitor identity. A possesses restricted developmental potential, defects in regulation potential can directly impinge on homeostasis contribute tumor initiation. Despite their importance, molecular mechanisms underlying precise cells remain largely unknown. We used type II neural (neuroblast) lineage Drosophila...
During asymmetric stem cell division, both the daughter and presumptive intermediate progenitor inherit cytoplasm from their parental cell. Thus, proper specification of identity requires an efficient mechanism to rapidly extinguish activity self-renewal factors, but mechanisms remain unknown in most lineages. division a type II neural (neuroblast) Drosophila larval brain, Brain tumor (Brat) protein segregates unequally into immature (INP), where it specifies INP by attenuating function...
Abstract The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit that composed of defined cell types, which approximately account more than half neurons in mammals. molecular mechanisms developmental progression maturation processes various types need systematic investigation. Here, we analyzed transcriptome profiles 21119 single cells the postnatal mouse identified eight main clusters. Functional annotation differentially expressed genes revealed...
We sought to determine the role of donor blood circulating leukocytes in mediating oxidative stress and inflammation during normothermic ex situ heart perfusion (ESHP). Normothermic ESHP allows preservation donated a perfused, dynamic state, preventing ischemia. However, cardiac function declines ESHP, limiting potential this method for improvement outcomes transplantation expanding pool. Extracorporeal circulation-related plays critical functional decline heart. Hearts from domestic pigs...
Background: Ex situ heart perfusion (ESHP) preserves the donated in a perfused, beating condition preventing cold storage–related ischemia and provides platform to evaluate myocardial viability during preservation. However, function declines gradually ESHP. Extracorporeal circulation systems are associated with induction of systemic inflammatory stress responses. Our aim was incidence inflammation endoplasmic reticulum responses an extended period Methods: Cardiac function, tissue injury,...
The current standard method for organ preservation (cold storage, CS), exposes the heart to a period of cold ischemia that limits safe time and increases risk adverse post-transplantation outcomes. Moreover, static nature CS does not allow evaluation or intervention during interval. Normothermic ex situ perfusion (ESHP) is novel donated minimizes by providing oxygenated, nutrient-rich perfusate heart. ESHP has been shown be non-inferior in standard-criteria donor hearts also facilitated...
Abstract Background The outcome of heart transplantation is significantly affected by perioperative infections. Individualised immunosuppression strategies are essential to reduce the risk such Case presentation We report successful management a 56-year-old male patient diagnosed with dilated cardiomyopathy who underwent transplantation. During period, was prescribed cefoperazone sodium and sulbactam sodium, which induced severe skin reaction: toxic epidermal necrolysis (TEN). treated...
Ex situ heart perfusion (ESHP) is being investigated as a method for the continuous preservation of myocardium in semiphysiologic state subsequent transplantation. Most methods ESHP position isolated hanging (H) state, representing considerable departure from vivo anatomical positioning and may negatively affect functional heart. In current study, cardiac metabolic parameters were assessed healthy pig hearts, perfused 12 hours, either an H, or supported (S) position, nonworking mode (NWM)...
Oxidative stress occurs during ex-situ heart perfusion (ESHP) and may negatively affect functional preservation of the heart. We sought to assess status key antioxidant enzymes ESHP, effects augmenting these antioxidants on attenuation oxidative improvement myocardial endothelial in ESHP. Porcine hearts were perfused for 6 hours with oxygen-derived free-radical scavengers polyethylene glycol (PEG)-catalase or PEG-superoxide dismutase (SOD) naive perfusate (control). The stress-related...
Self-care practices are integral part of heart failure (HF) management. Information-Motivation-Behavioral skills (IMB) model has shown promise in fostering better self-care behaviors, but its efficacy management HF patients remains underexplored. This retrospective study investigated the value IMB model-based nursing intervention for improving self-care, hemodynamic indicators, and quality life (QOL) patients.