A5089039390- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Fuel Cells and Related Materials
- Cardiac Imaging and Diagnostics
University of Alberta
2022-2025
Canadian VIGOUR Centre
2024-2025
ABSTRACT Introduction Preclinically, 24‐hour continuous Ex‐Situ Lung Perfusion (ESLP) is the longest duration achieved in large animal models and rejected human lungs. Here, we present our 36‐hour Negative Pressure Ventilation (NPV)‐ESLP protocol applied to porcine Methods Five sets of donor domestic pig lungs (45‐55 kg) underwent NPV‐ESLP. Two clinically were preserved on Graft function was assessed via physiologic parameters, edema formation, cytokine profiles. Results Porcine lung stable...
We sought to determine the role of donor blood circulating leukocytes in mediating oxidative stress and inflammation during normothermic ex situ heart perfusion (ESHP). Normothermic ESHP allows preservation donated a perfused, dynamic state, preventing ischemia. However, cardiac function declines ESHP, limiting potential this method for improvement outcomes transplantation expanding pool. Extracorporeal circulation-related plays critical functional decline heart. Hearts from domestic pigs...
Cold ex situ lung perfusion (ESLP) has demonstrated improved preservation in small animal ESLP compared to normothermic and cold static preservation. We hypothesized that negative pressure ventilation (NPV)-ESLP would improve graft function a porcine transplantation model. Four perfusate temperatures were examined with 12 hours NPV-ESLP large Pig lungs allotted four groups: (1) Normothermia (38°C, n = 6); (2) profound hypothermia (10°C, (3) moderate (20°C, 3); (4) subnormothermia (32°C, 3)....
Ex-Situ Lung Perfusion (ESLP) employs a membrane deoxygenator and mixed (N