A5033876312- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- Gestational Diabetes Research and Management
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Transplantation: Methods and Outcomes
- Mitochondrial Function and Pathology
- Ultrasound in Clinical Applications
- RNA modifications and cancer
- Child and Adolescent Psychosocial and Emotional Development
- Early Childhood Education and Development
- Coronary Artery Anomalies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Conditions and Treatments
- Non-Invasive Vital Sign Monitoring
University of Helsinki
2016-2025
Helsinki University Hospital
2016-2025
Helsinki Children's Hospital
2007-2024
Assistance Publique – Hôpitaux de Paris
2024
Université Paris Cité
2024
Children's Hospital
2014-2020
Institute for Molecular Medicine Finland
2018-2019
Finland University
2018-2019
University of Alberta
2012-2018
Women and Children’s Health Research Institute
2017
Importance Maternal diabetes and overweight or obesity are known to be associated with increased risk of congenital heart defects (CHDs) in offspring, but there no large studies analyzing outcomes these factors 1 model. Objective To investigate the association maternal CHDs among offspring Design, Setting, Participants This nationwide, population-based register study was conducted a birth cohort from Finland consisting all children born between 2006 2016 (620 751 individuals) their mothers....
Childhood-onset cardiomyopathies are rare and poorly characterized. This study examined the baseline characteristics 1-year follow-up of children with cardiomyopathy in first European Cardiomyopathy Registry.
Sudden cardiac death (SCD) is the most common mode of in childhood hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides clinicians with individualized estimates risk. aim this study was to externally validate a large independent, multi-centre patient cohort.
Up to one-half of childhood sarcomeric hypertrophic cardiomyopathy (HCM) presents before the age 12 years, but this patient group has not been systematically characterized. The aim study was describe clinical presentation and natural history patients presenting with nonsyndromic HCM years. Data from International Paediatric Hypertrophic Cardiomyopathy Consortium on 639 children diagnosed younger than years were collected compared those 568 between 16 At baseline, 339 (53.6%) had family...
Pulse oximetry screening of newborn infants increases early detection critical congenital heart disease and minimises the risk circulatory collapse before surgery. This study provides an update on implementation pulse in Nordic countries proposes standardised guidelines.A questionnaire exploring screening, clinical examination routines availability echocardiography was distributed to all 157 delivery units June 2013.We received responses from 156 units, 116 (74%) were using by September...
ABSTRACT Background Physical performance capacity (PPC) of pediatric heart transplant (HT) recipients is reportedly low to normal, and longitudinal follow‐up these patients recommended. However, no recommendation for a method available. In this study, the correlation between 6‐min walk test (6MWT), various clinical parameters, physical set was evaluated develop simple tool PPC. Methods Fifteen HT 392 historical controls were tested at median age 15.4 years. PPC with 6MWT consisting six...
Objective To assess whether intrapartum acidosis affects specific components of fetal heart rate variability. Design Prospective clinical study. Setting Twelve Nordic delivery units. Subjects Fetal variability was studied in 334 fetuses divided into two groups according to cord pH value: the acidotic group (cord arterial <7.05 at birth, n = 15) and control ≥7.05 319). Methods In spectral analysis variability, frequencies were integrated over total frequency band (0.04–1.0 Hz),...
Background: Autosomal dominantly inherited PRKAG2 cardiac syndrome is due to a unique defect of the cell metabolism and has distinctive histopathology with excess intracellular glycogen, prognosis different from sarcomeric hypertrophic cardiomyopathy.We aimed define distinct characteristics using cardiovascular magnetic resonance (CMR).Methods: CMR (1.5 T) genetic testing were performed in two families harboring mutations.On CMR, segmental analysis left ventricular (LV) hypertrophy (LVH),...
Background The aim of the study was to evaluate arterial morphology and function in a national cohort long‐term survivors high‐risk neuroblastoma (NBL) treated with high‐dose chemotherapy autologous hematopoietic stem cell transplantation or without total body irradiation (TBI). Methods Results Common carotid, femoral, brachial, radial artery were assessed very‐high‐resolution vascular ultrasound (25–55 MHz), carotid stiffness brachial flow‐mediated dilatation measured conventional 19 adult...
Artemia salina (brine shrimp) has been successfully used for toxicity testing, and a screening test phototoxicity developed based on this method. The ability of the method to phototoxic potential seven known compounds was investigated. Athamantin (an angular furanocoumarin) umbelliferone (a simple coumarin) showed no phototoxicity, while linear furanocoumarins exhibited activity in following order: psoralen > bergapten peucedanin xanthotoxin. applicability also tested plant material. Six...
Objective To evaluate whether a nationwide prenatal anomaly screening programme improves detection rates of univentricular heart ( UVH ) and transposition great arteries TGA ), maternal risk factors for severe fetal disease affect detection. Design Population‐based cohort study. Setting Nationwide data from Finnish registries 2004–14. Population A total 642 456 parturients 3449 terminated pregnancies due to anomaly. Methods Prenatal were calculated in three time periods (prescreening,...
Background: Maximal left ventricular wall thickness (MLVWT) is a risk factor for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). In adults, the severity of hypertrophy has nonlinear relationship with SCD, but it not known whether same complex seen childhood. The aim this study was to describe between and SCD large international pediatric HCM cohort. Methods: cohort comprised 1075 children (mean age, 10.2 years [±4.4]) diagnosed (1–16 years) from International Paediatric...
Abstract Background This study focuses on biomarkers in infants after open heart surgery, and examines the association of high‐sensitive troponin T (hs‐cTnT), interleukin‐6 (IL‐6), interleukin‐8 (IL‐8) with postoperative acute kidney injury (AKI), ventilatory support time need vasoactive drugs. Methods Secondary exploratory from a double‐blinded clinical randomized trial (Mile‐1) 70 undergoing surgery cardiopulmonary bypass (CPB). In this sub‐study, entire population was examined without...
Surgical strategy to construct a two-coronary system for patient with anomalous origin of left coronary artery from pulmonary (ALCAPA) has evolved time. Limited long-term follow-up data are available on these children. We report population-based in children operated ALCAPA. In total, 29 patients underwent aortic reimplantation ALCAPA between 1979 and 2006. Twenty (69%) were repaired direct implantation, five (17%) modified tubular extension technique, four (14%) an intrapulmonary baffling...
Together at School is a universal intervention program designed to promote socio-emotional skills among primary-school children. It based on whole school approach, and implemented in classes by teachers. The aim of the present study examine short-term effects improving reducing psychological problems boys girls. We also whether these depend grade level (Grades 1 3) dosage. This cluster randomized controlled trial design included 79 Finnish primary schools (40 39 control) with 3 704 outcome...
Abstract Loss of function variants in NOTCH1 cause left ventricular outflow tract obstructive defects (LVOTO). However, the risk conferred by rare and noncoding for LVOTO remains largely uncharacterized. In a cohort 49 families affected hypoplastic heart syndrome, severe form LVOTO, we discovered predicted loss 6% individuals. Rare or low‐frequency missense were found 16% families. To make quantitative estimate genetic posed studied associations 400 coding 1,085 cases 332,788 controls from...