A5026065185- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Platelet Disorders and Treatments
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Blood Coagulation and Thrombosis Mechanisms
- Blood donation and transfusion practices
- Venous Thromboembolism Diagnosis and Management
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Trauma and Emergency Care Studies
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
- Electrohydrodynamics and Fluid Dynamics
- Acute Kidney Injury Research
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
University of Gothenburg
2014-2025
Drottning Silvias barn- och ungdomssjukhus
2012-2024
Region Västra Götaland
2020-2024
Sahlgrenska University Hospital
2006-2024
Queen Fabiola Children's University Hospital
2014
Centre Hospitalier de l’Université de Montréal
2014
Centre Hospitalier Universitaire Brugmann
2014
The majority of pediatric cardiac surgery patients receive blood transfusions. We hypothesized that the routine use intraoperative thromboelastometry to guide transfusion decisions would reduce overall proportion receiving transfusions in surgery.One hundred were included study. Fifty (study group) prospectively and compared with 50 procedure- age-matched control (control group). In study group, thromboelastometry, performed during cardiopulmonary bypass, guided Intraoperative postoperative...
To evaluate the long-term use of secondary prevention medications [statins, β-blockers, renin-angiotensin-aldosterone system (RAAS) inhibitors, and platelet inhibitors] after coronary artery bypass grafting (CABG) association between medication mortality.
Although rotational thromboelastometry (ROTEM) is increasingly used to guide haemostatic therapy in a bleeding patient, there paucity of data guiding its use the paediatric population.The objective this study develop an algorithm on basis ROTEM values obtained our cardiac population management child.A retrospective analysis.Department Anaesthesiology, Queen Fabiola Children's University Hospital. Data were collected between September 2010 and January 2012.All children who underwent elective...
Abstract Background Haemorrhage is a leading cause of morbidity and mortality in trauma, prehospital transfusion blood products often necessary. Whole has been proposed to be the best alternative, but it unclear whether, how, storage transport helicopter affects units. We investigated coagulation capacity platelet function whole at different time points during missions. Methods Twenty units low‐titre group O RhD negative were collected from healthy volunteers analysed before, after...
Abstract Background and Objectives Access to blood components in pre‐hospital bleeding resuscitation is challenging. Dried plasma a logistically superior alternative, new products are emerging. Therefore, we aimed evaluate laboratory practical differences three differently produced dried products. Materials Methods Single‐donor lyophilized LyoPlas®, pooled‐donor, pathogen‐reduced OctaplasLG Powder®, single‐donor sprayed‐dried FrontlineODP™ along with fresh (in‐house, pre‐FrontlineODP...
Summary Objective Earlier detection of coagulopathy in pediatric cardiac surgery patients. Aim To determine whether thromboelastometry ( TEM ) analysis before weaning from cardiopulmonary bypass CPB and hemoconcentration is predictive post‐ results clot firmness already after 10 min yields reliable results. Background Cardiac with induces a that may contribute to postoperative complications. increases the possibility initiating countermeasures. Methods/Material Fifty‐six patients were...
Abstract Background This study focuses on biomarkers in infants after open heart surgery, and examines the association of high‐sensitive troponin T (hs‐cTnT), interleukin‐6 (IL‐6), interleukin‐8 (IL‐8) with postoperative acute kidney injury (AKI), ventilatory support time need vasoactive drugs. Methods Secondary exploratory from a double‐blinded clinical randomized trial (Mile‐1) 70 undergoing surgery cardiopulmonary bypass (CPB). In this sub‐study, entire population was examined without...
In vitro and in vivo studies have shown that mild systemic hypothermia influences platelet adhesion aggregation coagulation reactions. We wanted to test the hypothesis local healthy volunteers with preserved core temperature increased bleeding time. A secondary aim was evaluate if cooling influenced whole blood measured by thrombelastograph (TEG) same setting.Bleeding time at left volar forearm a baseline skin of 32 degrees C after 30 28 water bath. Skin continuously contact thermistors....
Objectives: It has been shown that, in contrast to other inotropic agents, levosimendan improves glomerular filtration rate after adult cardiac surgery. The aim of this study was investigate the efficacy levosimendan, compared with milrinone, preventing acute kidney dysfunction infants open-heart surgery cardiopulmonary bypass. Design: Two-center, double-blinded, prospective, randomized clinical trial. Setting: performed two tertiary pediatric centers, one Sweden (Gothenburg) and Finland...
Impaired platelet function increases the risk of bleeding complications in cardiac surgery. Reliable assessment can improve treatment. We investigated whether thromboelastometry detects clinically significant preoperative, perioperative, and postoperative adenosine diphosphate (ADP)-dependent dysfunction paediatric surgery patients.Fifty-seven children were included a single-centre prospective observational study. Clot formation (modified rotational with heparinase, HEPTEM) aggregation...
Shunt thrombosis after implantation of systemic-to-pulmonary shunts in paediatric patients is common. Acetyl salicylic acid used for anti-thrombotic treatment; however, the effect rarely monitored, although it known that response varies. The aim was to determine effects acetyl medication on platelet aggregation children with shunts.A total 14 – median age 12 days; ranging from 3 100 days were included a prospective observational longitudinal study. All treated oral (3–5 milligrams per...
Mechanical circulatory support for pediatric heart failure patients with the Berlin Heart EXCOR ventricular assist system is only approved and established bridging strategy recovery or transplantation. In recent years, burden of thromboembolic events has led to modifications recommended antithrombotic therapy. Therefore, we aimed assess practice among European Pediatric Investigator Group members.We sent a questionnaire assessing seven aspects therapy 18 hospitals using device children....
Preoperative testing of platelet function predicts bleeding risk in cardiac surgery patients treated with dual antiplatelet therapy, but the value postoperative testing, reflecting both preoperative therapy and perioperative changes function, has not been evaluated. Seventy-four acute coronary syndrome acetylsalicylic acid ticagrelor within 5 days before were included a prospective observational study. Platelet aggregation induced by adenosine diphosphate, arachidonic thrombin...
Guidelines recommend dual antiplatelet therapy after coronary artery bypass grafting (CABG) for patients with acute syndrome (ACS). However, the evidence these recommendations is weak.To compare midterm outcomes CABG in ACS treated postoperatively acetylsalicylic acid (ASA) and ticagrelor or ASA monotherapy.This cohort study used merged data from several national registries of Swedish who were diagnosed subsequently underwent CABG. All included isolated Sweden between 2012 2017 an diagnosis...
Heart failure is a rare condition in the paediatric population, associated with high morbidity and mortality. When medical therapy no longer sufficient, mechanical circulatory support such as ventricular assist device can be used to bridge these children transplant or recovery. Coagulation-related complications thrombi, embolism bleeding events represent greatest challenge patients on support. We aimed describe outcomes coagulation-related this patient population at our institution.A total...
We compared the effect of two inodilators, levosimendan and milrinone, on plasma levels myocardial injury biomarkers, that is, high-sensitivity troponin T heart-type fatty acid binding protein, N-terminal prohormone brain natriuretic peptide as a biomarker ventricular function. hypothesized could attenuate degree when with milrinone.A post hoc, nonprespecified exploratory secondary analysis Milrinone versus Levosimendan-1 trial (ClinicalTrials.gov Identifier: NCT02232399).Two pediatric...
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Extracorporeal circulation induces pronounced effects on haemostasis and rheology. To study these, an ex vivo simulation model is attractive alternative but often requires large amounts of blood. We sought to create a miniaturized roller pump circuit requiring minimal blood test if the could be used compare coagulation, platelet function rheology between dextran-based crystalloid-based priming solution.
Abstract Background: Haemodynamic instability is common after surgical repair of CHDs in infants and children. Monitoring cardiac output addition to traditional circulation parameters could improve the postoperative care these patients. Echocardiography transpulmonary thermodilution are two most methods for measuring infants. Objectives: To compare results measurements using echocardiography a setup paediatric surgery. Methods: Forty children, scheduled elective ventricular septal defect or...