A5065036391- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Heart Failure Treatment and Management
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Cardiac and Coronary Surgery Techniques
- Takotsubo Cardiomyopathy and Associated Phenomena
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Aortic aneurysm repair treatments
- Cardiovascular Disease and Adiposity
- Aortic Thrombus and Embolism
Sahlgrenska University Hospital
2017-2025
University of Gothenburg
2019-2025
Region Västra Götaland
2023-2024
Lund University
2013-2023
Skåne University Hospital
2012-2023
Molecular Medicine Ireland
2022
Gentofte Hospital
2014-2017
Institute of Cardiology
2017
Framingham Heart Study
2017
Boston University
2017
Transitions in the spectrum of valvular heart diseases (VHDs) developed countries over 20th century have been reported from clinical case series, but large, contemporary population-based studies are lacking.We used nationwide registers to identify all patients with a first diagnosis VHD at Swedish hospitals between 2003 and 2010. Age-stratified sex-stratified incidence each adjusted comorbidity profiles were assessed.In population (n=10 164 211), was 63.9 per 100 000 person-years, aortic...
Abstract Background Takotsubo syndrome (TS) and STEMI with timely reperfusion are both characterized by reversible acute myocardial dysfunction, often referred to as stunning. The natural course of cardiac functional recovery is incompletely understood in TS STEMI. aim this study was prospectively compare changes function over the subacute phases women versus anterior Methods Stunning Acute Myocardial Infarction (STAMI) enrolled 61 41 Echocardiography blood sampling performed within 4 h...
Background— The aging of Western populations is expected to result in increasing occurrence aortic stenosis (AS), but data are limited. Recent studies have reported declining incidence and mortality for other major heart diseases. We aimed study temporal trends the prognosis AS Sweden. Methods Results— With use nationwide registers, all adult patients Swedish population with a first diagnosis AS, failure, acute myocardial infarction, valve replacement between 1989 2009 were identified...
Abstract Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis animal models. Components NLRP3 pathway such as interleukin-1β can therapeutically be targeted. Associations genetically determined inflammasome-mediated systemic inflammation with CVD and mortality humans are unknown. Methods results We explored association genetic variants prevalent 538 167...
To evaluate the long-term use of secondary prevention medications [statins, β-blockers, renin-angiotensin-aldosterone system (RAAS) inhibitors, and platelet inhibitors] after coronary artery bypass grafting (CABG) association between medication mortality.
To gain a better understanding of the impact chronic obstructive pulmonary disease (COPD) on long-term mortality in patients with myocardial infarction (MI) and identify areas where clinical care for these may be improved.
The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact R46L variant on CAVS, and found that CAVS less prevalent carriers this (odds ratio: 0.80 [95% confidence interval: 0.70 0.91]; p = 0.0011) compared with noncarriers. expression higher valves patients control patients. In human interstitials cells submitted pro-osteogenic medium, levels increased...
Surgical risk, age, perceived life expectancy, and valve durability influence the choice between surgical aortic replacement (SAVR) transcatheter implantation. The contemporaneous expectancy after SAVR, in relation to risk is unknown. purpose of this study was determine median survival time chronological age SAVR patients. Patients ≥60 years with stenosis who underwent isolated a bioprosthesis (n = 8,353) were risk-stratified before surgery into low, intermediate, or high using logistic...
Early reperfusion in the setting of an ST-elevation myocardial infarction (STEMI) is utmost importance. However, effects early versus late this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent previous studies. The purpose study was to evaluate a nationwide cohort delay from first medical contact PCI (first [FMC]-to-PCI) and secondarily symptom-to-PCI on clinical outcomes.Using national Swedish Coronary Angiography Angioplasty Register...
Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways for AS could identify pharmacological targets.To novel genetic loci and associated with AS.This genome-wide association study used a case-control design to evaluate 44 703 participants (3469 cases of AS) self-reported European ancestry from the Genetic Epidemiology Research on Adult Health Aging (GERA) cohort (from January 1, 1996, December 31, 2015). Replication was performed in 7 other cohorts totaling...
Importance New-onset postoperative atrial fibrillation (POAF) occurs in approximately 30% of patients undergoing coronary artery bypass grafting (CABG). It is unknown whether early recurrence associated with worse outcomes. Objective To test the hypothesis that AF POAF after CABG Design, Setting, and Participants This Swedish nationwide cohort study used prospectively collected data from SWEDEHEART (Swedish Web System for Enhancement Development Evidence-Based Care Heart Disease Evaluated...
Objective— Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different factors. We examined relationship of carotid IMT incident AS in a prospective population-based study. Approach Results— A random sample participants (age, 45–68 years) Malmö Diet Cancer Study underwent B-mode ultrasound measurements presence common artery (n=5079). Potential for were studied...
Background and Purpose- Aortic valve stenosis may lead to atrial ventricular remodeling, predisposes fibrillation, also be an independent risk factor of ischemic stroke. However, information on stroke rates among persons with aortic are sparse. We aimed determine the incidence relative risks in individuals diagnosed compared age- sex-matched controls. Methods- All patients incident aged >18 years (n=79 310) controls were identified using Danish nationwide registries (1997-2017). Incidence...
Compared to men, women have been reported increased morbidity and mortality after ST-elevation myocardial infarction (STEMI); but sex differences in cardiac function the acute subacute phases of STEMI are incompletely understood. The objective this study was prospectively compare changes over anterior with timely reperfusion versus men. Stunning Takotsubo Acute Myocardial Infarction (STAMI) (NCT04448639) enrolled 105 men 41 STEMI. Echocardiography blood sampling were performed within 4 hours...
It has been suggested that long-term risk for incident cancer is increased in patients operated with cardiopulmonary bypass. We compared the and cancer-specific death between undergoing coronary artery bypass grafting (CABG) without All a history of first-time CABG Sweden during 1997-2020 were included nationwide population-based observational cohort study. Individual patient data from SWEDEHEART registry four other mandatory national registries merged. The incidence new was or using...
Background Cardiac surgery carries a heightened risk of bradyarrhythmias, but current permanent pacemaker (PPM) implantation estimates rely on non-contemporary studies. This study primarily aimed to explore the incidence and indications for PPM at 30 days 1 year after different cardiac surgical procedures in modern cohort. Secondary outcomes were 10 years time from implantation. Methods nationwide population-based included all patients Sweden who 2006 2020 underwent first-time coronary...
Abstract Background and Aims Physiological flow assessment of coronary stenoses, such as fractional reserve, are routinely used to guide percutaneous intervention, but it has not been equally recognized artery bypass grafting (CABG). Mid-term outcomes in CABG patients with without preoperative were compared. Methods All first-time isolated Sweden 2013-2020 identified the SWEDEHEART registry (n = 18 211), which also provided information on assessment. Data linked three mandatory national...
Aortic valvular stenosis (AS) is the most common cause of cardiac replacement surgery. During last century, pathogenesis AS has undergone transitions in developed countries, from rheumatic heart disease to a degenerative calcific pathogenesis. Although familial component been described for subset cases with bicuspid valve, data are limited on overall aggregation this disease.Contemporary information 6 117 263 Swedish siblings, which 13 442 had clinical diagnosis AS, was collected nationwide...
BackgroundAtelectasis after cardiac surgery is common and promotes ventilation/perfusion mismatch, infection, delayed discharge from critical care. Recruitment manoeuvres are often performed to reduce atelectasis. In severe respiratory failure, recruitment in the prone position may increase oxygenation, survival, or both. We compared effects of vs supine on lung aeration oxygenation surgical patients.MethodsSubjects were randomised (40 cm H2O peak inspiratory pressure 20 PEEP for 30 s)...
Journal Article Stable incidence and outcomes for patients with incident aortic stenosis: how can we translate excellent trial data into improved clinical in the population? Get access Andreas Martinsson, Martinsson Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, SwedenDepartment Molecular Clinical Medicine, Institute Academy, Sweden Corresponding author. Tel: +46 709841884, Fax: 46 157857, Emails: andreas.s.martinsson@gmail.com; andreas.s.martinsson@vgregion.se...
Abstract OBJECTIVES The aim of this study was to evaluate the association between statin use after surgical aortic valve replacement for stenosis and long-term risk major adverse cardiovascular events (MACEs) in a large population-based, nationwide cohort. METHODS All patients who underwent isolated due Sweden 2006–2020 survived 6 months discharge were included. Individual patient data from 5 registries merged. Primary outcome is MACE (defined as all-cause mortality, myocardial infarction or...