A5023586883- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Congenital heart defects research
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiovascular Conditions and Treatments
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Blood Pressure and Hypertension Studies
- Viral Infections and Immunology Research
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2016-2025
University of Freiburg
2016-2025
Deutsches Herzzentrum der Charité
2002-2023
University Medical Center Freiburg
2014-2023
Fistula Foundation
2020
University Hospital Heidelberg
2020
Heidelberg University
2020
University Medical Center Hamburg-Eppendorf
2017
Creative Research Enterprises (United States)
2017
Zero to Three
2017
Abstract Background and Aims Landiolol, an ultra-fast acting super-selective beta-blocker, was investigated for the first time in Europe a prospective clinical study management of supraventricular tachycardia (SVT) among paediatric patients. Methods LANDI-PED prospective, multicentre, open-label, uncontrolled phase III aiming to investigate efficacy, safety, pharmacokinetics (PK) landiolol 60 patients surgical non-surgical settings aged ≥1 day <18 years with SVTs various aetiologies...
Increased pulmonary vascular resistance (PVR) because of congenital heart disease (CHD) may be caused by a dysfunction in endogenous endothelial nitric oxide (NO) production. In other forms with increased PVR, an elevated activity phosphodiesterase type 5 (PDE-5), responsible for the degradation cyclic guanidine monophosphate (cGMP), second messenger endothelially produced NO, has been demonstrated. This study compares effects inhaled NO before and after specific inhibition PDE-5 intravenous...
<h3>Background</h3> Ostium secundum atrial septal defects (ASDII) account for approximately 10% of all congenital heart (CHD), and mutations in cardiac transcription factors, including <i>TBX20</i>, were identified as an underlying cause ASDII. However, very little is known about disease penetrance families functional consequences inherited TBX20 mutations. <h3>Methods</h3> The coding region <i>TBX20</i> was directly sequenced 170 ASDII patients. Functional one novel mutation investigated by...
Objectives: The purpose of this study was to characterize hemodynamic alterations and flow-derived vessel wall parameters in aortic coarctation (CoA) patients with without operative repair by time-resolved, 3-dimensional, 3-directional velocity sensitive, phase-contrast magnetic resonance imaging (4D PC MRI) comparison healthy subjects. Methods Material: Twenty-four patients, 12.5 ± 6.4 years after CoA repair, 4 treatment for CoA, 19 subjects were examined. approved the institutional review...
Background: National estimates of Kawasaki disease (KD) incidence often do not include incomplete cases (diagnosed based on only laboratory or echocardiographic criteria), and/or they rely retrospective case reports and data registries where underreporting is known to be a problem. Methods: We conducted prospective nationwide KD surveillance study in children younger than 5 years through the hospital-based German Pediatric Surveillance Unit (ESPED). accounted for applying capture–recapture...
The aim of this 4D flow cardiovascular magnetic resonance (CMR) follow-up study was to investigate longitudinal changes in aortic hemodynamics adolescent patients with Marfan syndrome (MFS). CMR for the assessment in-vivo 3D blood full coverage thoracic aorta performed twice (baseline scan t1/follow-up t2) 19 MFS (age at t1: 12.7 ± 3.6 years, t2: 16.2 4.3 years) a mean duration 3.5 1.2 years. Ten healthy volunteers (24 3.8 served as control group. Data analysis included visualization by...
Primary cardiac tumours are rare. The literature predominantly contains series on myxomas in adults and only a few long-term that involve the very different primary early childhood. As foetal ultrasonography has continued to improve, increasingly detected before significant symptoms develop. It is challenge for paediatric cardiologists surgeons ascertain which patients need surgery will benefit from conservative follow-up.A retrospective review of 10-year period revealed 51 26 children...
Objective: To apply flow-sensitive magnetic resonance imaging for the evaluation of whole-heart flow characteristics in healthy volunteers and patients with Fontan circulation. Methods: Time-resolved three-dimensional velocity mapping (spatial resolution = 2.5 × 2.8 mm3, temporal 38.4 ms) was acquired normal controls four extracardiac total cavopulmonary connection. Data analysis included connectivity quantification arterial venous blood flow. Haemodynamics circulation were individually...
Abstract Purpose: To apply time‐resolved three‐dimensional (3D) phase contrast MRI with three‐directional velocity encoding (flow‐sensitive 4D MRI) for the characterization of flow pattern changes in patients Marfan syndrome (MFS) compared normal controls. Materials and Methods: Flow‐sensitive thoracic aorta (temporal resolution ∼45 ms, spatial ∼2.4 × 2.1 2.8 mm 3 ) was performed 24 MFS 10 volunteers. Aortic patterns were visualized by 3D particle traces streamlines. Global (affecting...
Rationale: In chronic heart failure, increased adrenergic activation contributes to structural remodeling and altered gene expression. Although signaling alters histone modifications, it is unknown, whether also affects other epigenetic processes, including DNA methylation its recognition. Objective: The aim of this study was identify the mechanism regulation methyl-CpG–binding protein 2 (MeCP2) functional significance during cardiac pressure overload unloading. Methods Results: MeCP2...
Background: Diverse scores on high-risk Kawasaki disease (KD) patients have proven a good prognostic validity in the Japanese population. However, data non-Japanese been inconclusive. Do Kobayashi, Egami and Sano or application of up-to-date statistical methods (Random Forest) predict response to standard intravenous immunoglobulin (IVIG) therapy risk persistent coronary artery aneurysm (CAA) with KD mainly Caucasian population Germany? Methods: Data 442 children (German population-based...
EUROMACS is a registry of the European Association for Cardio-Thoracic Surgery (EACTS) whose purpose to gather clinical data related durable mechanical circulatory support scientific purposes and publish annual reports. Because treatment children with end-stage heart failure has several significantly different characteristics than adults, outcomes interventions are analysed in this dedicated paediatric report.Participating hospitals contributed pre-, peri- long-term postoperative on implants...
The outcome of acute myocarditis with cardiogenic shock is poor. In some children in whom aggressive medical treatment fails, artificial replacement heart function may offer lifesaving support until the myocardium has recovered. Four previously healthy (three boys aged 4, 6, and 1 years; one girl 5) developed ventricular failure multiorgan dysfunction caused by low cardiac output. Biventricular assist devices (BVAD) were implanted for prolonged support. three improved after up to 21 days...