Christoph Male
A5074594620- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Pharmaceutical studies and practices
- Central Venous Catheters and Hemodialysis
- Cancer-related gene regulation
- Atrial Fibrillation Management and Outcomes
- Chronic Myeloid Leukemia Treatments
- Heart Failure Treatment and Management
- Vascular anomalies and interventions
- Cardiac Arrhythmias and Treatments
- Systemic Lupus Erythematosus Research
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Pharmaceutical Economics and Policy
- Child and Adolescent Health
- Epilepsy research and treatment
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Medical University of Vienna
2016-2025
Universitätsklinik für Kinder und Jugendpsychiatrie
2013-2024
University of Vienna
1993-2023
Vienna General Hospital
2001-2023
Medizinische Hochschule Hannover
2023
Spanish National Centre for Cardiovascular Research
2023
University of Bamberg
2023
Building Bridges
2023
Artificial Intelligence in Medicine (Canada)
2023
Guy's and St Thomas' NHS Foundation Trust
2023
The development of neutralizing anti–factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.
Summary Objective To compare the efficacy and safety of ketogenic diet ( KD ) with standard adrenocorticotropic hormone ACTH treatment in infants West syndrome. Methods In this parallel‐cohort (PC) randomized controlled trial RCT ), were randomly allocated to or high‐dose . Those who could not be followed a PC Primary end point was electroclinical remission at day 28. Secondary points time remission, relapse after initial response, seizure freedom last follow‐up, adverse effects,...
The incidence of FIX inhibitors in severe hemophilia B (SHB) is not well defined. Frequencies 3-5% have been reported but most studies to date were small, including patients with different severities, and without prospective follow-up for inhibitor incidence. Study objective was investigate SHB followed up 500 exposure days (ED), the frequency allergic reactions, relationship genotypes. Consecutive previously untreated (PUPs) enrolled into PedNet cohort included. Detailed data collected...
Anticoagulant treatment of pediatric cerebral venous thrombosis has not been evaluated in randomized trials. We the safety and efficacy rivaroxaban standard anticoagulants predefined subgroup children with (CVT) who participated EINSTEIN-Jr trial. Children CVT were (2:1), after initial heparinization, to or (continued on heparin switched vitamin K antagonist). The main period was 3 months. primary outcome, symptomatic recurrent thromboembolism (VTE), principal major clinically relevant...
Among patients younger than 21 years of age, the optimal duration anticoagulant therapy for venous thromboembolism is unknown. To test hypothesis that a 6-week provoked noninferior to conventional 3-month in age. Randomized clinical trial involving 417 age with acute, enrolled at 42 centers 5 countries from 2008-2021. The main exclusions were severe deficiencies or prior thromboembolism. Patients without persistent antiphospholipid antibodies and whose thrombi resolved not completely...
A prospective longitudinal cohort study was performed to assess the prevalence of iron deficiency in European infants at 12 mo age, and influence socio-economic status, dietary factors, growth morbidity on status. The consisted 488 normal term from primary healthcare centres 11 areas. Assessed were variables, intake, anthropometry regular intervals birth mo, haemoglobin, serum ferritin, mean corpuscular volume, transferrin saturation receptor concentrations age mo. anaemia 9.4%, 7.2%, 2.3%....
Summary Deep vein thrombosis (DVT) in children occurs primarily the upper body venous system. This prospective diagnostic study compared bilateral venography and ultrasound for detection of DVT system 66 with acute lymphoblastic leukemia. Results were interpreted by central blinded adjudication. occurred 29% (19/66) patients. While 15/19 detected (sensitivity 79%), only 7/19 37%). The 12 but not located subclavian or more veins. Three 4 jugular vein. We conclude that is insensitive may be...
To investigate if the factor V Leiden mutation (F-V-LM) and/or prothrombin gene G 20210 A variant (P-G20210A-V) are risk factors for acute stroke in Austrian children.33 children with ischemic documented by computer tomography magnetic resonance imaging of brain were enrolled an open multicenter survey.6/33 had F-V-LM (5 heterozygous, 1 homozygous). This represents 18% (95% CI: 6.7-39.9%) our pediatric population and thus exceeds expected prevalence 4,6% (Fischer's exact test, p = 0.01). was...
The goals were to assess the frequency of spontaneous closure isolated secundum atrial septal defect in children and identify predictors closure.A retrospective cohort study was performed a tertiary care pediatric cardiology center. Consecutive patients (n = 200) diagnosed as having defects (no multiple or fenestrated defects, no additional congenital heart disease, syndromes) monitored for > 6 months with serial 2-dimensional echocardiography, according standardized protocol.The median age...
The life expectancy of non-severe hemophilia A (HA) patients equals the non-hemophilic population. However, data on effect inhibitor development mortality and hemophilia-related causes death are scarce. neutralizing factor VIII antibodies in HA may dramatically change their clinical outcome due to severe bleeding complications.We assessed association between occurrence inhibitors with HA.In this retrospective cohort study, vital status were collected for 2709 (107 inhibitors) who treated...