A5075582793- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Cancer-related gene regulation
- Blood Coagulation and Thrombosis Mechanisms
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Hemostasis and retained surgical items
- Chronic Lymphocytic Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Body Contouring and Surgery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Anesthesia and Sedative Agents
- Peripheral Neuropathies and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Case Reports on Hematomas
- Wound Healing and Treatments
- Venous Thromboembolism Diagnosis and Management
- Periodontal Regeneration and Treatments
- Intensive Care Unit Cognitive Disorders
Fundación para la Investigación, Docencia y Prevención del Cáncer
2010-2024
Favaloro Foundation
2011-2023
Central Bank of Argentina
2023
Haemophilia Foundation Australia
2015-2022
National Hemophilia Foundation
2021
Leiden University Medical Center
2017
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017
University of Milan
2017
Instituto Argentino de Diagnóstico y Tratamiento
2013
Academia Nacional de Medicina
2000
The development of neutralizing anti–factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.
Analysis of outcomes patients enrolled in the World Bleeding Disorders Registry (WBDR). 87 Hemophilia Treatment Centers around world participating WBDR. Data on 10,276 people with hemophilia demonstrate wide discrepancies care globally. Care provided low-income countries lags behind high-income by up to 40 years.
People with mild haemophilia (PWMH) experience sporadic bleeds and are less likely to receive an early diagnosis, appropriate treatment medical care. Arthropathy is a key determinant of health-related quality life (QoL), producing pain, limitations in mobility daily activities. The aim this study evaluate the incidence, risk factors QoL associated arthropathy PWMH.Observational, cross-sectional cohort study. Data were collected single interview evaluated by physiotherapist orthopaedist...
Haemophilic synovitis is caused by chronic accumulation of blood in the joint. Conservative treatment insufficient to solve this pathology. Platelet-rich plasma (PRP) has a high concentration growth factors (GFs) that play key role regulation and stimulation healing processes. The aim study was describe effect PRP injection joints patients with haemophilia (PWH).Nineteen 28 were treated at our centre Buenos Aires, Argentina between December 2014 2015. Eighteen Haemophilia type A (17 severe,...
Summary Development of inhibitors against factor VIII (FVIII) or FIX is the most serious complication replacement therapy in patients with haemophilia. Haemophilic pseudotumours a patient can lead to devastating consequences. The aim this study show our experience treatment 10 7 who were treated by same multidisciplinary team period between January 2000 and March 2013. Seven severe haemophilia A at Haemophilia Foundation Buenos Aires, Argentina, for pseudotumours. Eight bone two soft tissue....
Summary Inhibitor development against exogenous factor VIII is a severe impairment of replacement therapy affecting 18% Argentine patients with haemophilia A ( HA ). To study the molecular predisposition for inhibitor development, we genotyped 260 and without inhibitors, countrywide. The inhibitor‐positive population (19 transients, 15 low responders, LR 70 high HR ) 104 severe‐ showed 59 Inv22 (intron 22 inversions), 18 small ins/del‐frameshifts, 12 gross deletions, nonsense, one splicing...
Hemophilia A (HA) provides excellent models to analyze genotype-phenotype relationships and mutational mechanisms. NhF8ld's breakpoints were characterized using case-specific DNA-tags, direct- or inverse-polymerase chain reaction amplification, Sanger sequencing. DNA-break's stimulators (n = 46), interspersed repeats, non-B-DNA, secondary structures analyzed around versus null hypotheses (E-values) based on computer simulations base-frequency probabilities. Nine of 18 (50%) severe-HA...
Wound healing is an intricate process whereby the skin repairs itself after injury according to a specific sequence: haemostasis, inflammation, proliferation and remodelling. Cell therapy has potential improve wound conditions can be applied in both acute chronic wounds. Normal requires adequate haemostatic function. Patients with coagulation disorders whose function altered may not heal naturally.The aim of this study was show simple, safe inexpensive minimally invasive technique for repair...
Abstract Introduction Primary prophylaxis is the current gold standard in haemophilia care for prevention of bleeding and ensuing joint damage. Early detection bleeding, whether symptomatic or subclinical, preferably during childhood, helps prevent deterioration subsequent disability. The aim this study to evaluate level agreement between Haemophilia Joint Health Score Arthropathy Detection with Ultrasound tools children severe on primary secondary prophylaxis. Materials Methods All patients...
The haemophilic arthropathy is a disabling disease that causes chronic pain and functional limitation, due to recurrent intra-articular bleeding, with impaired quality of life.The aim this work present our 24-year experience in the treatment subchondral cysts filled hydroxyapatite coralline patients haemophilia.Thirty-seven male forty-nine cystic lesions were treated evaluated between 1990 2014. Thirty four haemophilia type A, three B, two had inhibitors factor VIII. average age was 23.6...
A 68-year-old man, with Hairy Cell Leukemia developed a Guillain-Barré syndrome (G-B). 32 days after single course of 2-Chlorodeoxyadenosine (CDA) at 0.14 mg/k/d. for five in two-hour-i.v. infusion and following febrile neutropenia episode. In order to clarify whether this G-B case was related an infection or CDA neurotoxicity. we screened infection-related autoimmune antibodies (abs.) against gangliosides peripheral nerves. Blood urinary cultures were negative as well serum anti-virus abs....
Abstract: We report the clinical, cytogenetic, fluorescence in situ hybridization (FISH) and molecular findings a 54‐yr‐old male patient diagnosed with B‐cell chronic lymphocytic leukemia (B‐CLL), who showed progression to diffuse large lymphoma (Richter's syndrome). Genetic studies were performed at diagnosis during Richter's transformation (RT). A clonal karyotype two dicentric chromosomes, psu dic(12,21)(q24;q10) dic(17,18)(p11.2;p11.2), was found. Both rearrangements confirmed by FISH....