A5054552795- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Neurogenetic and Muscular Disorders Research
- Eosinophilic Disorders and Syndromes
- Venous Thromboembolism Diagnosis and Management
- Case Reports on Hematomas
- Chronic Myeloid Leukemia Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Periodontal Regeneration and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hemostasis and retained surgical items
Hospital Fernández
2015-2024
Favaloro Foundation
2015-2024
Haemophilia Foundation Australia
2015-2022
Fundación para la Investigación, Docencia y Prevención del Cáncer
2016
People with mild haemophilia (PWMH) experience sporadic bleeds and are less likely to receive an early diagnosis, appropriate treatment medical care. Arthropathy is a key determinant of health-related quality life (QoL), producing pain, limitations in mobility daily activities. The aim this study evaluate the incidence, risk factors QoL associated arthropathy PWMH.Observational, cross-sectional cohort study. Data were collected single interview evaluated by physiotherapist orthopaedist...
Haemophilic synovitis is caused by chronic accumulation of blood in the joint. Conservative treatment insufficient to solve this pathology. Platelet-rich plasma (PRP) has a high concentration growth factors (GFs) that play key role regulation and stimulation healing processes. The aim study was describe effect PRP injection joints patients with haemophilia (PWH).Nineteen 28 were treated at our centre Buenos Aires, Argentina between December 2014 2015. Eighteen Haemophilia type A (17 severe,...
Abstract Introduction The impact of joint damage on functional capacity in patients with mild haemophilia (PwMH) has yet to be well studied. primary aim this study was investigate the effect impairment lower limb PwMH. secondary identify physical predictors capacity. Method Forty‐nine PwMH were evaluated. Dynamic balance assessed using Time Up and Go (TUG). Thirty‐second sit‐to‐stand (30‐STS) 60‐second‐STS (60‐STS) used assess muscle power endurance, respectively. Haemophilia Early...
Repeated joint bleeding leads to chronic synovitis, cartilage damage and bone alterations which result in haemophilic arthropathy are associated with pain, functional impairment poor quality of life. There evidence that Hyaluronic Acid (HA) Platelet-rich Plasma (PRP) have different mechanisms action the treatment for this reason we decided use both components. The aim study is compare, efficacy, safety duration a single intra-articular injection PRP against PRP+HA episodes health, same...
Knee flexion contracture (KFC) remains a common complication of haemoarthrosis in children and young adults with haemophilia. If the KFC is not treated properly it produces disability, postural gait abnormalities.Evaluate effectiveness conservative treatment Botulinum toxin type A (BTX-A) PWH.Seventeen patients were treated, 21 affected knees. Mean age was 26 years. The mean follow up 12 months. We evaluated pretreatment BTX-A to months posttreatment. application hamstring calf muscles. To...
Abstract Introduction and Aim Haemarthroses cause major morbidity in haemophilia resulting chronic haemophilic synovitis (CHS) arthropathy. Oxidation of haemoglobin‐coupled iron released synovium after haemolysis induces chondrocytes death cartilage damage, allowing postulate using iron‐chelating drugs as potential therapeutic tool for joint damage. Considering that albumin, the most abundant plasma protein, is a physiologic chelator, we aim to demonstrate impediment haemoglobin oxidation...
Hemarthrosis causes chronic haemophilic synovitis (CHS). Although neutrophils are major immune cells infiltrating joints after bleeding, their role on the pathogenesis of CHS is unknown. Neutrophils release extracellular DNA traps (ETs), structures with bound granular enzymes that were associated tissue damage.To evaluate presence ETs as pathogenic biomarker and protective effect intraarticular injection platelet-rich plasma (PRP) in patients CHS.Haemophilia Joint Health Score (HJHS)...
Abstract Introduction Primary prophylaxis is the current gold standard in haemophilia care for prevention of bleeding and ensuing joint damage. Early detection bleeding, whether symptomatic or subclinical, preferably during childhood, helps prevent deterioration subsequent disability. The aim this study to evaluate level agreement between Haemophilia Joint Health Score Arthropathy Detection with Ultrasound tools children severe on primary secondary prophylaxis. Materials Methods All patients...
Regular assessment of motor impairments is crucial in people with haemophilic arthropathy (PwHA). This study aimed to determine if there are differences 30-seconds sit-to-stand (30-STS) power and maximal voluntary isometric contraction (MVIC) the knee extensors between PwHA healthy control group (CG). The secondary aims were investigate correlation 30-STS MVIC clinical characteristics assess their effectiveness identifying impairment PwHA.
Aim: Iliopsoas Haemorrhage (IPH) is a well-recognized complication of haemophilia. The aim this paper to show thecurrent epidemiology IPH in patients with haemophilia (PWH) treated at Argentinean Haemophilia Foundation, and observethe evolution the treatment disease over years. Patients methods: 1995 series included 109 PWH 223 episodes IPH. Eighty-six (80.4%) hadHaemophilia A twenty-one (19.6%) had B, mean age was 18 years old. 2008-2013 thirty-sixPWH sixty-five Twenty-nine (80.6%) seven...
La sinovitis es una de las complicaciones más frecuentes la enfermedad hemofílica producida por depósitos intraarticulares hemosiderina. Noventa y nueve pacientes con hemofilia, 124 articulaciones, fueron tratados inyección intraarticular rifampicina entre 1992 2001. El seguimiento medio fue 5 años. edad promedio 15 Doce presentaban inhibidores al factor VIII. Las articulaciones afectadas fueron: 28 (22,6%) codos, 19 (15,3%) tobillos 77 (62,1%) rodillas. inyecciones en relación cada...
Prophylaxis is the gold standard treatment for children with haemophilia (CWH). MRI studies revealed joint damage, even this treatment; suggests presence of subclinical bleeding.In case haemophilia, it relevant to detect early signs as allows medical team provide appropriate and follow-up, in order avoid arthropathy development its consequences. The aim study hidden on prophylaxis (CWHP) analyse, by age group, which most affected. We define CWH that presents damage secondary repetitive...
Background: Inhibitor development is the main treatment-related complication in patients with hemophilia. Degenerative joint lesions caused by repeated bleeding episodes are more common inhibitors than those without inhibitors. We introduced Platelet-rich Plasma (PRP) treatment to reduce damage and provide symptomatic relief. Objectives: The aim of this study was compare PRP outcomes two groups hemophilia presenting synovitis, or inhibitors, at 3- 6-month follow-ups. Methods: treated 87 143...