Fanny Bajolle
A5024307257- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Congenital heart defects research
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- Cardiomyopathy and Myosin Studies
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Aortic Disease and Treatment Approaches
- Health, Medicine and Society
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
Hôpital Necker-Enfants Malades
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2013-2024
Délégation Paris 5
2009-2024
Laboratoire National de Référence
2024
Université Sorbonne Paris Nord
2022
Institut Necker Enfants Malades
2020-2021
German Centre for Cardiovascular Research
2021
Deutsches Herzzentrum der Charité
2021
Sorbonne Paris Cité
2012-2020
Background: Cardiac injury and myocarditis have been described in adults with coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome 2 (SARS-CoV-2) infection children is typically minimally symptomatic. We report a series of febrile pediatric patients heart failure potentially associated SARS-CoV-2 the multisystem inflammatory as defined by US Centers for Disease Control Prevention. Methods: Over 2-month period, contemporary pandemic France Switzerland, we retrospectively...
To describe the characteristics of children and adolescents affected by an outbreak Kawasaki-like multisystem inflammatory syndrome to evaluate a potential temporal association with severe acute respiratory coronavirus 2 (SARS-CoV-2) infection.Prospective observational study.General paediatric department university hospital in Paris, France.21 (aged ≤18 years) features Kawasaki disease who were admitted between 27 April 11 May 2020 followed up until discharge 15 2020.The primary outcomes...
Current data suggest that COVID-19 is less frequent in children, with a milder course. However, over the past weeks, an increase number of children presenting to hospitals greater Paris region phenotype resembling Kawasaki disease (KD) has led alert by French national health authorities. Multicentre compilation patients KD since April 2020, associated detection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ('Kawa-COVID-19'). A historical cohort 'classical' served as...
<h3>Importance</h3> Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with acute respiratory coronavirus 2 infection, potentially life-threatening, but optimal therapeutic strategy remains unknown. <h3>Objective</h3> To compare intravenous immunoglobulins (IVIG) plus methylprednisolone vs IVIG alone as initial therapy MIS-C. <h3>Design, Setting, and Participants</h3> Retrospective cohort study drawn from a national surveillance system...
MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 and CD8 T cells that poorly respond to SARS-CoV-2 antigens.
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 or RNASEL five unrelated with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing generate 2′-5′-linked oligoadenylates (2-5A) activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines primary myeloid cells OAS1, OAS2, RNase produce excessive amounts cytokines upon dsRNA acute...
Congenital heart defects frequently involve a failure of outflow tract (OFT) formation during development. We analyzed the remodeling OFT, using y96-Myf5-nlacZ-16 transgene, which marks subpopulation myocardial cells pulmonary trunk. Expression analyses reporter transcript and protein suggest that wall OFT rotates before great arteries. Rotational movement was confirmed by Di-I injection experiments with cultured embryos. subsequently examined expression transgene in mouse models for...
OBJECTIVES: To describe presentation, hospital course, and predictors of bad outcome in multisystem inflammatory syndrome children (MIS-C). METHODS: Retrospective data review a case series meeting the published definition for MIS-C who were discharged or died between March 1, 2020, June 15, from 33 participating European, Asian, American hospitals. Data collected through Web-based survey included clinical, laboratory, electrocardiographic, echocardiographic findings treatment management....
Anticoagulant treatment of pediatric cerebral venous thrombosis has not been evaluated in randomized trials. We the safety and efficacy rivaroxaban standard anticoagulants predefined subgroup children with (CVT) who participated EINSTEIN-Jr trial. Children CVT were (2:1), after initial heparinization, to or (continued on heparin switched vitamin K antagonist). The main period was 3 months. primary outcome, symptomatic recurrent thromboembolism (VTE), principal major clinically relevant...
Background: Acute clinical manifestations of SARS-CoV-2 infection are less frequent and severe in children than adults. However, recent observations raised concerns about potential post-viral inflammatory reactions infected with SARS-CoV-2. Methods: We describe an outbreak cases Kawasaki disease (KD) admitted between April 27 May 7, 2020, the general paediatrics department a university hospital Paris, France. All prospectively underwent nasopharyngeal swabs for RT-PCR, IgG serology testing,...
Cardiopulmonary fitness in congenital heart disease (CHD) decreases faster than the general population resulting impaired health-related quality of life (HRQoL). As standard care seems insufficient to encourage and maintain fitness, an early hybrid cardiac rehabilitation programme could improve HRQoL CHD. The QUALIREHAB multicentre, randomized, controlled trial evaluated implemented a 12-week centre- home-based programme, including multidisciplinary physical activity sessions. Adolescent...
NK cells are key players in the fight against persistent viruses. Human cytomegalovirus (HCMV) infection is associated with presence of a population CD16(+) CD56(dim) NKG2C(+) both acutely and latently infected individuals. Here, we studied nature these terminally differentiated different human populations HCMV: healthy donors stratified by age, thymectomized individuals, pregnant women suffering from primary CMV infection, lung transplant patients. Both NK- CD8 T-cell phenotypes as well...
Although cardiac neural crest cells are required at early stages of arterial valve development, their contribution during valvular leaflet maturation remains poorly understood. Here, we show in mouse that from pre-otic and post-otic regions make distinct contributions to the leaflets. Genetic fate-mapping analysis Krox20-expressing shows a large borders interleaflet triangles valves. Loss Krox20 function results hyperplastic aortic partially penetrant bicuspid formation. Similar defects...