A5090634980- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Neurogenetic and Muscular Disorders Research
- Parathyroid Disorders and Treatments
- Streptococcal Infections and Treatments
- Neonatal and fetal brain pathology
- Congenital Diaphragmatic Hernia Studies
- Neonatal and Maternal Infections
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Renal function and acid-base balance
- Effects and risks of endocrine disrupting chemicals
- Parvovirus B19 Infection Studies
- Medical Imaging and Pathology Studies
- Thyroid and Parathyroid Surgery
- Immune Response and Inflammation
- Pharmaceutical Economics and Policy
- Autoimmune and Inflammatory Disorders Research
- Biomedical Research and Pathophysiology
- Infant Development and Preterm Care
- Kawasaki Disease and Coronary Complications
- Anesthesia and Neurotoxicity Research
Hospices Civils de Lyon
2017-2025
Inserm
2017-2024
Université Claude Bernard Lyon 1
2021-2024
Hôpital Louis Pradel
2021-2024
Centre National de la Recherche Scientifique
2022-2024
Laboratoire de Biométrie et Biologie Evolutive
2021-2024
HCL Technologies (India)
2024
Hôpital Edouard Herriot
2024
Hôpital Lyon Sud
2020
bioMérieux (France)
2020
MIS-C is characterized by a polyclonal activation of Vβ21.3 + CD4 and CD8 T cells that poorly respond to SARS-CoV-2 antigens.
Primary hyperoxaluria type 1 (PH1) is a rare, progressive, genetic disease with limited treatment options. We report the efficacy and safety of lumasiran, an RNA interference therapeutic, in infants young children PH1.This single-arm, open-label, phase 3 study evaluated lumasiran patients aged <6 years PH1 estimated glomerular filtration rate >45 mL/min/1.73 m2, if ≥12 months, or normal serum creatinine, <12 months. The primary end point was percent change spot urinary oxalate to creatinine...
Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier for the treatment patients with spinal muscular atrophy (SMA). The JEWELFISH study (NCT03032172) was designed to assess safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) risdiplam in previously treated pediatric adult types 1–3 SMA. Here, an analysis performed after all had received at least 1 year risdiplam. Patients confirmed diagnosis 5q-autosomal recessive SMA between ages 6 months 60 years were...
Significant muscle wasting develops in critically ill adults, with subsequent worse outcomes. In the pediatric setting, occurrence and effects of are undescribed; this is part due to a lack validated, objective methods for assessing wasting. A single measurement quadriceps femoris thickness has failed show consistent reproducibility. We hypothesized that averaging repeated measurements could afford good reproducibility allow decline detection monitoring.A prospective bedside observational...
Abstract Background ANCHOVY was a global, multicenter, chart-review study that aimed to describe the natural history of Type 1 spinal muscular atrophy (SMA) from broad geographical area and provide further contextualization results FIREFISH (NCT02913482) interventional risdiplam treatment in SMA. Methods Data were extracted medical records patients with first symptoms attributable SMA between 28 days 3 months age, genetic confirmation SMA, confirmed survival motor neuron 2 copy number two or...
Transient hypothyroxinemia of prematurity (THOP) has been associated with suboptimal neurodevelopment. We aimed to assess neurodevelopment in very preterm infants treated and untreated THOP. This study was a multicentre, cohort study, based on prospectively collected data four French level III neonatal intensive care units. Infants born before 32 weeks gestation between 2009 2020 who underwent thyroid function test were included. THOP defined as low free thyroxine unelevated stimulating...
Abstract Background Fever is one of the leading causes consultation in pediatric emergency department for patients under age 3 years. Distinguishing between bacterial and viral infections etiologies febrile remains challenging. We hypothesized that specific host biomarkers infections, such as type I-interferon (IFN), could help clinicians’ decisions limit antibiotic overuse. Methods Paxgene tubes serum were collected from children (n = 101), 7 days to 36 months, with proven or being treated...
Lung involvement in childhood Langerhans cell histiocytosis (LCH) is infrequent and rarely life threatening, but occasionally, severe presentations are observed.Among 1482 children (< 15 years) registered the French LCH registry (1994-2018), 111 (7.4%) had lung involvement. This retrospective study included data for 17 (1.1%) patients that required one or more intensive care unit (ICU) admissions respiratory failure.The median age was 1.3 years at first ICU hospitalization. Of patients, 14...
Objectives: Micronutrient supplementation in critically ill adults remains controversial. In the pediatric setting, impact of oxidative stress on overall micronutrient status has been poorly explored, due to limited number studies and confounding factors (i.e., malnutrition or extra losses). order better understand this phenomenon, we aim describe status, focusing seven micronutrients, well-nourished children presenting with severe stress. Design: Prospective, transversal, observational,...
Despite the high prevalence of late-onset sepsis (LOS) in neonatal intensive care units, a reliable diagnosis remains difficult. This prospective, multicenter cohort study aimed to identify biomarkers early rule out LOS 230 neonates ≥7 days life with signs suspected LOS. Blood levels eleven protein (PCT, IL-10, IL-6, NGAL, IP-10, PTX3, CD14, LBP, IL-27, gelsolin, and calprotectin) were measured. Patients received standard blinded biomarker results, an independent adjudication committee...
Toxic shock syndromes (TSS) are severe shocks due to staphylococcal or streptococcal infection that require specific treatments. The early recognition of these is crucial improve their outcomes. Objectives primary objective this study was compare characteristics and outcomes TSS in children, order identify putative clinical diagnostic criteria. Secondary objectives were determine the toxin gene profiles associated isolated strains relevance measuring Vβ T-cell signatures confirm diagnosis....
Purpose Toxic shock syndrome (TSS) is a rare disease responsible for significant morbidity and mortality. Intravenous immunoglobulin (IG) therapy in paediatric TSS could improve organ failure, but more consistent efficacy safety data are needed. Our objective was to determine whether randomised clinical trial (RCT) assessing intravenous IG children feasible. Methods We performed multicentre, feasibility, double-blind RCT of high-dose versus albumin 4% (control group) within the first 12...
Abstract Objectives Bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants. This study aimed at identifying factors associated with early or late weaning failure from respiratory support oxygen (O 2 ) infants BPD requiring O therapy after discharge neonatal intensive care unit (NICU). Methods retrospective was conducted NICU of a tertiary hospital, born before 32 weeks gestation between 2012 and 2021, discharged (tracheostomy [TT], invasive ventilation [IV],...
Regarding nirsevimab immunization status, among 1085 infants hospitalized for bronchiolitis, the odds of hospitalization respiratory syncytial virus bronchiolitis were 4.7 times higher nonimmunized children. Immunized less likely to require oxygen supplementation (20.2% vs. 30.6%, P = 0.02) and had a 1-day shorter hospital stay. Respiratory was frequent severe in immunized with nirsevimab.