A5019495317- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Glaucoma and retinal disorders
- Advanced Differential Geometry Research
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Sympathectomy and Hyperhidrosis Treatments
- Facial Trauma and Fracture Management
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Vestibular and auditory disorders
- IgG4-Related and Inflammatory Diseases
- Retinal Diseases and Treatments
- Otitis Media and Relapsing Polychondritis
- Retinal Development and Disorders
- Neurogenetic and Muscular Disorders Research
- Thyroid Cancer Diagnosis and Treatment
- Nasal Surgery and Airway Studies
- Ocular and Laser Science Research
- Medical and Biological Ozone Research
- Amyotrophic Lateral Sclerosis Research
- Retinal Imaging and Analysis
- Facial Rejuvenation and Surgery Techniques
- Corporate Governance and Law
- Peripheral Nerve Disorders
Essen University Hospital
2017-2025
Ophthalmology Clinic
2017-2024
Praxis für Humangenetik
2023
Orthopädische Praxis
2023
Universitätsklinik für Augenheilkunde
2018-2022
University of Duisburg-Essen
2020-2022
St. Franziskus Hospital
2017
Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier for the treatment patients with spinal muscular atrophy (SMA). The JEWELFISH study (NCT03032172) was designed to assess safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) risdiplam in previously treated pediatric adult types 1–3 SMA. Here, an analysis performed after all had received at least 1 year risdiplam. Patients confirmed diagnosis 5q-autosomal recessive SMA between ages 6 months 60 years were...
Introduction Graves’ disease (GD) is an autoimmune disorder caused by autoantibodies against the thyroid stimulating hormone receptor (TSHR) leading to overstimulation of gland. Thyroid eye (TED) most common extra thyroidal manifestation GD. Therapeutic options treat TED are very limited and novel treatments need be developed. In present study we investigated effect linsitinib, a dual small-molecule kinase inhibitor insulin-like growth factor 1 (IGF-1R) Insulin (IR) on outcome GD TED....
Severity of Graves' orbitopathy (GO) shows wide individual differences. For optimal treatment, it is important to be able predict the natural course disease as accurate possible counteract with anti-inflammatory and surgical treatment. Therefore, we aimed further elucidate impact sex, age smoking on GO.We collected clinical demographic data all patients our tertiary referral center from January 2008 till December 2018 analyzed descriptive statistics. Only a complete set were included in...
Abstract The aim of this study was to evaluate and compare the efficacy intravenous (iv) glucocorticoids (GCs) with without orbital radiotherapy (ORT) in a retrospective analysis patients active, moderate-to-severe Graves’ orbitopathy (GO). Since diplopia has strongest impact on quality life, careful work up motility binocular single vision (BSV) been performed. Essen-EUGOGO-Center database (n=3655) screened for untreated moderate-to-severe, active GO, onset ≤12 months. inclusion criteria...
Graves' orbitopathy (GO) is an autoimmune disorder leading to inflammation, adipogenesis, and fibrosis. The severity of GO can vary widely among individuals, making it challenging predict the natural course disease accurately, which important for tailoring treatment approach individual patient. aim this study was compare clinical characteristics, course, treatment, prognosis patients under 50 years with older patients.
Graves' orbitopathy (GO) is the most common extra thyroidal complication of disease (GD) and occurs predominantly in women but more severe men. The reason for this effect gender on GO unknown. Herein we studied manifestation both sexes an induced mouse model absence additional risk factors present patients like advanced age, genetic variabilities or smoking. Male female mice were immunized with human TSHR A-subunit encoding plasmid. Both comparably developed autoimmune hyperthyroidism...
Summary Experimental models of Graves' hyperthyroid disease accompanied by orbitopathy (GO) can be induced efficiently in susceptible inbred strains mice immunization electroporation heterologous human TSH receptor (TSHR) A-subunit plasmid. In this study, we report on the development a bona fide murine model autoimmune with homologous mouse TSHR Autoimmune thyroid self-antigen was GO and characterized histopathology hyperplastic glands large follicular cells. Examination orbital tissues...
Background/Aims: We performed a retrospective analysis to examine clinical results, establish dose-effect coefficient and analyze the long-term efficacy of tendon elongation with bovine pericardium (Tutopatch®) for surgical correction severe esotropia, occurring after three-wall orbital decompression dysthyroid optic neuropathy in patients Graves' orbitopathy (GO).Methods: Tendon medial rectus muscle (MR) was our institution using an interponate 60 (27 underwent unilateral 33 bilateral...
Orbital decompression surgery is performed in patients with Graves' orbitopathy to treat dysthyroid optical neuropathy (DON) and reduce disfiguring proptosis. The intended proptosis reduction can deviate from the postoperative result changes of motility consecutive diplopia occur. We a retrospective study identify anatomical factors computed tomography (CT), which influence surgical effect ocular diplopia.Pre- CT-scans 125 eyes 68 patients, who mainly underwent balanced orbital for (≥18mm...
Abstract The aim of this study was to investigate the potential new TSH-receptor antibody (TRAb) assays predict remission or relapse hyperthyroidism in patients with Graves’ disease (GD) and orbitopathy (GO). TRAbs were measured retrospectively sera from a cohort GD GO (n=117; n=38 n=79–Essen biobank) automated binding immunoassays: TRAb Elecsys (Cobas Roche) bridge assay (IMMULITE, Siemens), TSAb (thyroid stimulating Ab) cell-based bioassay (Thyretain, Quidel Corp.). To identify...
Abstract The inflammatory eye disease Graves’ orbitopathy (GO) is the main complication of autoimmune disease. In previous studies we have shown that hypoxia plays an important role for progression GO. Hypoxia can maintain inflammation by attracting cells such as macrophages (MQ). Herein, investigated interaction MQ and orbital fibroblasts (OF) in context hypoxia. We detected elevated levels marker HIF-1α, CD68, cytokines TNFα, CCL2, CCL5, CCL20 GO biopsies. stimulated tissues to release...
The aim of the study was to investigate use serial measurements TSH-receptor autoantibodies (TRAb) with newest available assay technology predict course Graves' Orbitopathy (GO) during first 24 months from disease onset. Serial serum samples patients GO (103 mild/135 severe) were collected between 2007 and 2017 retrospectively analyzed. classified into mild/severe 12 after manifestation (severe: NOSPECS≥5; mild<5). TRAb measured automated binding immunoassays (IU/l): Elecsys (Cobas, Roche),...
Currently, therapeutic management of patients with Graves' orbitopathy (GO) relies on clinical assessments and MRI. However, monitoring inflammation remains difficult since external inflammatory signs do not necessarily represent the orbital disease activity. Therefore, we aimed to evaluate diagnostic value 18F-FDG-PET/MRI assess GO patients.Enrolled new onset underwent ophthalmological examinations activity (CAS) severity (NOSPECS), as well an (Siemens Biograph mMR) dual time point imaging...
Non-specific orbital inflammation (NSOI) and IgG4-related disease (IgG4-ROD) are often challenging to differentiate. Furthermore, it is still uncertain how chronic inflammation, such as IgG4-ROD, can lead mucosa-associated lymphoid tissue (MALT) lymphoma. Therefore, we aimed evaluate the diagnostic value of gene expression analysis differentiate autoimmune diseases elucidate genetic overlaps. First, established a database NSOI, relapsing IgG4-ROD MALT lymphoma patients our center...
<b><i>Purpose:</i></b> While the importance of risk polymorphisms for pathogenesis age-related macular degeneration (AMD) is well established, their impact on morphological and functional phenotypes largely unclear. We aimed to characterize individual in patients who were either homozygous a allele CFH gene, ARMS2 or both as compared non-carriers. <b><i>Methods:</i></b> Patients with early AMD (<i>n</i> = 85) assessed during...
Abstract Introduction and purpose Patients with Graves' orbitopathy (GO) may develop restricted elevation; this can lead to hypotropia, sometimes in combination an abnormal head posture. Recession of one or both inferior rectus muscles is the first line surgery restore eye motility these patients. However, result A pattern strabismus. This study was performed determine rate occurrence type incomitant strabismus potential predictive factors. Methods All patients undergoing on two over a...
The aim of the study was to identify possible risk factors for new onset diplopia in 20° primary position (NOD PP) after orbital decompression. A predisposition NOD has been established patients with pre-existing secondary gaze; therefore, authors focused on without preoperative diplopia.Retrospective chart review who underwent balanced decompression between 2012 and 2019 due Graves orbitopathy at authors' institution. Exclusion criteria were incomplete clinical data set, revision surgery,...
Abstract Background Although most patients with visual impairment due to corneal diseases can be treated successfully surgery, some require rehabilitation restore reading ability. To evaluate the best LVAs especially in terms of speed and characterize this specific patient group we performed a prospective, randomized cross-over trial. Methods All 34 underwent detailed examination (slit-lamp, funduscopy, SD-OCT, ETDRS) as screening. Only without other ocular were included. Reading-speed was...
Our purpose was to assess response after ablation of thyroid remnants (ATR) with radioactive iodine therapy in patients unstable Graves' orbitopathy (GO) subtotal thyroidectomy. Methods: Thirty mild (n = 4, 13%), moderate-to-severe 25, 83%), or very severe GO 1, 3%) were analyzed this retrospective study. The primary endpoint the improvement GO-related symptoms as assessed by clinical activity scores, NOSPECS, and soft-tissue inflammation scores at 3 12 mo ATR. Ablation success defined a...
Purpose:We conducted this trial to investigate a new wearable laser-eyewear (LEW).Images of an integrated camera are projected the retina by RGB-Laser (<1µW) and MEMS-mirror system.This enables full-color live video as augmented reality embedded in field vision wearer.Thin parallel laser beams following principle Maxwellian view through center ocular lens ensure independency refractive errors.We performed study with healthy subjects test independency.Materials Methods: LEW was tested 20...
To determine the outcome after orbital decompression using a graduated technique, adapting surgical technique according to individual patients' disease characteristics.We retrospectively examined postoperative in patients treated with balanced regarding reduction of proptosis, new onset diplopia and improvement visual function. 542 (1018 orbits) were between 2012 2020 included study. Clinical examinations including acuity, exophthalmometry (Hertel) orthoptic evaluation performed...