A5050227832- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Colorectal and Anal Carcinomas
- Voice and Speech Disorders
- Artificial Intelligence in Healthcare and Education
- Acute Myeloid Leukemia Research
- Nasal Surgery and Airway Studies
- Medical Practices and Rehabilitation
- Chronic Myeloid Leukemia Treatments
- Bone Tissue Engineering Materials
- Ear and Head Tumors
- Bone Tumor Diagnosis and Treatments
- AI in cancer detection
- Bone and Joint Diseases
- Dental materials and restorations
- Facial Trauma and Fracture Management
- Facial Nerve Paralysis Treatment and Research
- Pituitary Gland Disorders and Treatments
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2016-2025
Essen University Hospital
2016-2025
Klinikum rechts der Isar
2024-2025
Technical University of Munich
2024-2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2017-2024
University of Duisburg-Essen
2015-2024
München Klinik
2024
Ludwig-Maximilians-Universität München
2016-2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2019-2021
Van Lang University
2021
Abstract Purpose: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of pathologically expanded myeloid with immunosuppressive activity. In human disease, three major MDSC subpopulations can be defined as monocytic (M-MDSC), granulocytic [polymorphonuclear-MDSC (PMN-MDSC)], and early stage (e-MDSC), which lacks lineage markers the former two subsets. The purpose this study was to determine compare capacity clinical relevance each these subsets in patients solid cancer....
Visual diagnosis is one of the key features squamous cell carcinoma oral cavity (OSCC) and oropharynx (OPSCC), both subsets head neck (HNSCC) with a heterogeneous clinical appearance. Advancements in artificial intelligence led to Image recognition being introduced recently into large language models (LLMs) such as ChatGPT 4.0. This exploratory study, for first time, evaluated application image by diagnose leukoplakia based on images, images without any lesion control group. A total 45 were...
Background: Age at diagnosis is incorporated into all relevant staging systems for differentiated thyroid carcinoma (DTC). There growing evidence that a specific age cutoff may not be ideal accurate risk stratification. We sought to evaluate the interplay between and oncologic variables in patients with DTC using largest cohort date. Methods: The Surveillance, Epidemiology, End Results (SEER) database was queried identify as their only malignancy period 1973 2009. Multivariate analyses range...
Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation of anti-cancer adaptive immunity. Neutrophils form substantial population cells LNs with poorly understood functions. Here, we demonstrate that, head neck (HNC) progression, tumor-associated neutrophils transmigrate to shape anti-tumor responses stage-dependent manner. In metastasis-free stages (N0), develop an antigen-presenting phenotype (HLA-DR+CD80+CD86+ICAM1+PD-L1−) stimulate T...
Head and neck squamous cell carcinoma (HNSCC) is a complex malignancy that requires multidisciplinary tumor board approach for individual treatment planning. In recent years, artificial intelligence tools have emerged to assist healthcare professionals in making informed decisions. This study investigates the application of newly published LLM Claude 3 Opus compared currently most advanced ChatGPT 4.0 diagnosis therapy planning primary HNSCC. The results were conventional board; (2)...
Background Head and neck squamous cell carcinoma (HNSCC) is a complex malignancy that requires multidisciplinary approach in clinical practice, especially tumor board discussions. In recent years, artificial intelligence has emerged as tool to assist healthcare professionals making informed decisions. This study investigates the application of ChatGPT 3.5 4.0, natural language processing models, decision-making. Methods We conducted pilot October 2023 on 20 consecutive head cancer patients...
Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition mature and immature lack specific markers. Here, we focus on CD66b+CD10+CD16+CD11b+ PMN-MDSCs (mPMN-MDSCs) from either cancer patients or healthy donors receiving G-CSF for stem cell mobilization (GDs). By RNA sequencing (RNA-seq) experiments, report the identification a distinct gene signature shared different mPMN-MDSC populations under...
Radioactive iodine (RAI) is a key component in the treatment of differentiated thyroid cancer. RAI has been recommended more selectively recent years as guidelines evolve to reflect risks and utility certain patient subsets. In this study we sought evaluate survival impact radioactive specific cancer subgroups. Nationwide retrospective cohort patients using National Cancer Database (NCDB) from 2004 2012 Surveillance, Epidemiology, End Results (SEER) database 1992 2009 examining with treated...
Neutrophil extracellular traps (NETs) represent web-like structures consisting of externalized DNA decorated with granule proteins that are responsible for trapping and killing bacteria. However, undesirable effects NET formation during carcinogenesis, such as metastasis support, have been described. In the present study, we evaluated correlation between NETosis disease progression in head neck cancer (HNC) patients order to establish a valid biomarker an early detection monitoring HNC...
<title>Abstract</title> <bold>(1) Objectives: </bold>Artificial intelligence (AI) has demonstrated potential in supporting decision making processes oncology by assisting the multidisciplinary tumor board (MDT). This study evaluates performance of two AI-based decision-support tools, most recently introduced ChatGPT o1 and established 4o, compared to MDT treatment recommendations head neck squamous cell carcinoma (HNSCC). Survival outcomes patterns were analyzed a large publicly accessible...
Zusammenfassung Die Indikation zur elektiven Neck Dissection (END) bei Patienten mit T1/2-Plattenepithelkarzinomen des Hypopharynx (HPSCC) und Oropharynx (OPSCC) wird nicht einheitlich gestellt. In der vorliegenden Studie erfolgte daher eine detaillierte Analyse Metastasierungsverhaltens von HPSCC OPSCC. Es multizentrische retrospektive nodalen onkologischen Parameter 262 chirurgisch therapierten HPSCC- OPSCC-Patienten. Zudem systematische Literaturrecherche. Bei HPSCC-Patienten lag in 62,1%...
In the tumor host, neutrophils may exhibit protumor or antitumor activity. It is hypothesized that in response to host-derived therapy-induced factors, adopt diverse functional states ultimately execute these differential functions. Here, we provide an alternative scenario which of individual cell population determines overall versus outcome neutrophil‒tumor interactions. Experimentally, show human neutrophils, are sequentially stimulated with bacteria and secreted factors from cells, kill a...
Abstract Purpose This study aimed to explore the capabilities of advanced large language models (LLMs), including OpenAI’s GPT-4 variants, Google’s Gemini series, and Anthropic’s Claude in addressing highly specialized otolaryngology board examination questions. Additionally, included a longitudinal assessment GPT-3.5 Turbo, which was evaluated using same set questions one year ago identify changes its performance over time. Methods We utilized question bank comprising 2,576 multiple-choice...
Target-blind activity-based screening of molecular libraries is often used to develop first-generation compounds, but subsequent target identification rate-limiting developing improved agents with higher specific affinity and lower off-target binding. A fluorescently labeled nerve-binding peptide, NP41, selected by phage display, highlights peripheral nerves in vivo. Nerve highlighting has the potential improve surgical outcomes facilitating intraoperative nerve identification, reducing...
Nerve degeneration after transection injury decreases intraoperative visibility under white light (WL), complicating surgical repair. We show here that the use of fluorescently labeled nerve binding probe (F-NP41) can improve visualization chronically (up to 9 months) denervated nerves. In a mouse model for repair facial nerves, fluorescent labeling decreased time identification by 40% compared surgeries performed WL alone. Cumulative functional post-operative recovery was also significantly...
Recurrent and metastatic head neck squamous cell carcinoma (HNSCC) is characterized by a complex therapeutic management that needs to be discussed in multidisciplinary tumor boards (MDT). While artificial intelligence (AI) improved significantly assist healthcare professionals making informed treatment decisions for primary cases, an application the even more recurrent/metastatic setting has not been evaluated yet. This study also represents first evaluation of recently published LLM ChatGPT...
The capability of Pseudomonas aeruginosa and Staphylococcus aureus to form biofilm on varying CI component materials differs in the presence absence bioactive glass (BAG). application BAG induces significant changes morphology which can be visualized via scanning electron microscopy (SEM). Bacterial formation medical devices, such as cochlear implants (CI), lead chronic infections. Interestingly, type S53P4 seems a promising tool for use reduction development. Primarily, four bacterial...
Accurate therapeutic management of the neck is a challenge in patients with supraglottic laryngeal cancer. Nodal metastasis common at all disease stages, and treatment planning relies on clinical staging neck, for both surgical non-surgical treatment. Here, we compared results carcinoma treated primary surgery to assess accuracy pre-therapeutic guide future decisions.Retrospective analysis clinical, pathological, oncologic outcome data 70 bilateral dissection Patients where pathological...
Cancer of unknown primary (CUP) is a heterogeneous entity with limited prognosis. Novel prognostic markers are needed for patient stratification in prospective clinical trials exploring innovative therapies. Methods: In CUP patients treated at the West German Center Essen, value 18F-FDG PET/CT initial diagnostic workup was analyzed by comparing overall survival (OS) who underwent those did not. Results: Of 154 diagnosis, 76 workup. The median full analysis set 20.0 mo. Within subgroup, an...
Objectives/Hypothesis Additional intraoperative guidance could reduce the risk of iatrogenic injury during parotid gland cancer surgery. We evaluated use fluorescently labeled nerve binding peptide NP41 to aid facial identification and preservation parotidectomy in an orthotopic model murine cancer. also quantified accuracy detection for surface buried nerves head neck with versus white light (WL) alone. Study Design Twenty‐eight mice underwent surgeries additional fluorescence (FL) WL...
Tumor-draining lymph nodes (TDLNs) are the first organs where metastatic spread of different types cancer, including head and neck cancer (HNC), occurs have therefore high prognostic relevance. Moreover, anti-cancer immune responses been shown to be initiated in such LNs via tumor-educated myeloid cells. Among cells present TDLNs, neutrophils represent a valuable population considerably participate activation effector lymphocytes there. Tumor-supportive or tumor-inhibiting activity strongly...
For practical reasons, in many studies PD-L1 expression is measured by combined positive score (CPS) from a single tumor sample. This does not reflect the heterogeneity of head and neck squamous cell carcinoma (HNSCC). We investigated extent relevance HNSCC analyzing primary tumors recurrences (LRs), as well metastases. Tumor tissue 200 patients was immunohistochemically stained for analyzed using image-analysis software QuPath v3.4 with multiple specimens per patient. CPS ≥20 25.6% tumors....