A5085978001- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Vascular Anomalies and Treatments
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Chemokine receptors and signaling
- Tracheal and airway disorders
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Adipokines, Inflammation, and Metabolic Diseases
- Cytokine Signaling Pathways and Interactions
- Hemophilia Treatment and Research
- Blood disorders and treatments
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
- Otitis Media and Relapsing Polychondritis
- Sharing Economy and Platforms
- Diet, Metabolism, and Disease
- Cardiovascular Disease and Adiposity
- S100 Proteins and Annexins
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
University of Duisburg-Essen
2018-2025
Essen University Hospital
2016-2025
German Cancer Research Center
2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2022-2023
Universitäts-HNO-Klinik Heidelberg
2023
National Research University Higher School of Economics
2021
National Medical Research Center of Cardiology
2019-2020
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2020
Institute of Experimental Cardiology
2010-2020
Ministry of Health of the Russian Federation
2012-2017
Tumor-draining lymph nodes (LNs) play a crucial role during cancer spread and in initiation of anti-cancer adaptive immunity. Neutrophils form substantial population cells LNs with poorly understood functions. Here, we demonstrate that, head neck (HNC) progression, tumor-associated neutrophils transmigrate to shape anti-tumor responses stage-dependent manner. In metastasis-free stages (N0), develop an antigen-presenting phenotype (HLA-DR+CD80+CD86+ICAM1+PD-L1−) stimulate T...
Tumor‐associated neutrophils (TANs) regulate many processes associated with tumor progression, and depending on the microenvironment, they can exhibit pro‐ or antitumor functions. However, molecular mechanisms regulating their tumorigenicity are not clear. Using transplantable models, we showed here that nicotinamide phosphoribosyltransferase (NAMPT), a molecule involved in CSF3R downstream signaling, is essential for tumorigenic conversion of TANs pro‐angiogenic switch. As result...
Neutrophil extracellular traps (NETs) represent web-like structures consisting of externalized DNA decorated with granule proteins that are responsible for trapping and killing bacteria. However, undesirable effects NET formation during carcinogenesis, such as metastasis support, have been described. In the present study, we evaluated correlation between NETosis disease progression in head neck cancer (HNC) patients order to establish a valid biomarker an early detection monitoring HNC...
Neutrophils are known to play an important regulatory role during tumor progression in several types of cancer. However, the mechanisms responsible for their tumorigenic bias and extended lifespan cancer not clear date. This study uncovers a previously unknown mechanism by which tumor-derived small extracellular vesicles (sEVs), via serpin cargo, reprogram neutrophils adopt tumor-supporting phenotype. We demonstrated here elevated content plasma sEVs head neck progression, significant cargo...
<title>Abstract</title> Despite advancements in cancer therapies, bacterial complications remain a major challenge, delaying treatment and worsening outcomes. While immunosuppressive therapies prolonged hospitalizations contribute, they do not fully explain the elevated infection risk patients. We observed that G-CSF production by tumors was associated with persistence of Gram-negative pathogens head neck squamous cell carcinoma The presence oral rinse positively correlated poor prognosis...
Pseudomonas aeruginosa is an opportunistic multidrug-resistant pathogen, able to grow in biofilms. It causes life-threatening complications diseases, which are characterized by the up-regulation of type I interferon (IFN) signaling, such as cancer or viral infections. Since IFNs known regulate multiple functions neutrophils that constitute first line anti-bacterial host defense, this work we aimed study how interferon-activated influence course P. infection lung. After infection, observed...
Abstract Angiogenesis plays an important role during tumor growth and metastasis. We could previously show that Type I interferon (IFN)‐deficient tumor‐associated neutrophils (TANs) strong pro‐angiogenic activity, stimulate angiogenesis growth. However, the exact mechanism responsible for their shift is not clear. Here, we set out to delineate molecular factors regulating properties of in context IFN availability. demonstrate from IFN‐deficient ( Ifnar1 −/− ) mice efficiently release...
Tumor-draining lymph nodes (TDLNs) are the first organs where metastatic spread of different types cancer, including head and neck cancer (HNC), occurs have therefore high prognostic relevance. Moreover, anti-cancer immune responses been shown to be initiated in such LNs via tumor-educated myeloid cells. Among cells present TDLNs, neutrophils represent a valuable population considerably participate activation effector lymphocytes there. Tumor-supportive or tumor-inhibiting activity strongly...
Granulocyte-colony stimulating factor (G-CSF)/nicotinamide phosphoribosyltransferase (NAMPT) signaling has been shown to be crucial for the modulation of neutrophil development and functionality. As this pathway is significantly suppressed by type I interferons (IFNs), we aimed study how regulation differentiation phenotype altered in IFN-deficient mice during granulopoiesis. The composition bone marrow granulocyte progenitors their Nampt expression were assessed IFN receptor knockout...
To study the role of lipoprotein(a) [Lp(a)] as a potential autoantigen causing activation immunocompetent cells in atherosclerosis.A total 104 men with stable coronary artery (CA) disease and different degrees progressive atherosclerosis were examined. Clinical blood analysis was carried out lymphocyte subpopulations (CD4+, Th1, Th17, Treg) determined using immunofluorescence flow cytometry. In addition, indicators lipid composition, Lp(a), autoantibody (autoAb) titer to low-density...
Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated with flow cytometry 79 patients 45 healthy individuals, association clinicopathological status was assessed. A prominent decrease absolute numbers T cells revealed (0.7...
The role of neutrophils during cancer formation and elimination is diverse. Here, for the first time, we investigate neutrophil helper cells (NBH), their influence on B cell activity in regional lymph nodes (RLN) head-and-neck patients effect this neutrophil/B interaction patient prognosis. Circulating RLN with stage I–IV squamous carcinoma were investigated flow cytometry qPCR. In addition, co-localization RLNs was evaluated using immunohistochemistry. proliferation assessed correlated...
Sepsis is associated with profound immune dysregulation that increases the risk for life-threatening secondary infections: Dendritic cells (DCs) undergo functional reprogramming due to yet unknown changes during differentiation in bone marrow (BM). In parallel, lymphopenia and exhaustion of T lymphocytes interfere antigen-specific adaptive immunity. We hypothesized there exists a link between modulation DC BM murine polymicrobial sepsis. was induced by cecal ligation puncture (CLP), model...
Cardiovascular toxicity is one of the important problems clinical oncology. Atherosclerosis progression was demonstrated in patients with cancer and chemotherapy. Te aim – to evaluate vascular wall characteristics determine predictors AS brachiocephalic arteries during anticancer therapy breast cancer. Methods. study involved 43 newly diagnosed (BC) (II–III stage) overexpression HER2; median age 50 (40;57) years. All underwent neoadjuvant drug antracyclines, taxanes trastuzumab followed by...
Immune and inflammatory reactions contribute to the progression of atherosclerosis. The walls different arteries segments have heterogeneous haemodynamic histological features. We aimed explore relationship between circulating T-cell subsets abundance carotid atherosclerosis in arteries.70 patients underwent ultrasound duplex scanning determine degree stenosis common artery (CCA), CCA bifurcation or internal (ICA). blood frequencies T-, B-, NK-cells, regulatory T cells (Treg), activated...