A5019175541- Cancer Immunotherapy and Biomarkers
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- AI in cancer detection
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Nonmelanoma Skin Cancer Studies
- Ocular Oncology and Treatments
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer and Skin Lesions
- Brain Metastases and Treatment
- Immune Cell Function and Interaction
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Systemic Lupus Erythematosus Research
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Polyomavirus and related diseases
- Genetic and rare skin diseases.
- Inflammatory Myopathies and Dermatomyositis
- Anesthesia and Pain Management
University Hospital Cologne
2019-2024
University of Cologne
2019-2024
Integrated Oncology (United States)
2024
Heinrich Heine University Düsseldorf
2024
Düsseldorf University Hospital
2024
Essen University Hospital
2011-2019
University of Duisburg-Essen
2013-2018
Deutschen Konsortium für Translationale Krebsforschung
2015-2017
University Hospital of Bern
2017
University of Bern
2017
Abstract To develop criteria for the classification of fibromyalgia, we studied 558 consecutive patients: 293 patients with fibromyalgia and 265 control patients. Interviews examinations were performed by trained, blinded assessors. Control group primary matched age sex, limited to disorders that could be confused fibromyalgia. secondary‐concomitant age, concomitant rheumatic disorders. Widespread pain (axial plus upper lower segment left‐ right‐sided pain) was found in 97.6% all 69.1% The...
The diagnosis of most cancers is made by a board-certified pathologist based on tissue biopsy under the microscope. Recent research reveals high discordance between individual pathologists. For melanoma, literature reports 25-26% for classifying benign nevus versus malignant melanoma. A recent study indicated potential deep learning to lower these discordances. However, performance in histopathologic melanoma images was never compared directly human experts. aim this perform such first...
BackgroundThe diagnosis of most cancers is made by a board-certified pathologist based on tissue biopsy under the microscope. Recent research reveals high discordance between individual pathologists. For melanoma, literature reports 25–26% for classifying benign nevus versus malignant melanoma. Deep learning was successfully implemented to enhance precision lung and breast cancer diagnoses. The aim this study illustrate potential deep assist human assessment histopathologic melanoma...
Tumor‐associated neutrophils (TANs) regulate many processes associated with tumor progression, and depending on the microenvironment, they can exhibit pro‐ or antitumor functions. However, molecular mechanisms regulating their tumorigenicity are not clear. Using transplantable models, we showed here that nicotinamide phosphoribosyltransferase (NAMPT), a molecule involved in CSF3R downstream signaling, is essential for tumorigenic conversion of TANs pro‐angiogenic switch. As result...
Conjunctival melanoma is a potentially deadly eye tumour. Despite effective local therapies, tumour recurrence and metastasis remain frequent. The genetics of conjunctival melanomas incompletely understood.A large cohort 63 was screened for gene mutations known to be important in other subtypes by targeted next-generation sequencing. Mutation status correlated with patient prognosis.Frequent genes activating the MAP kinase pathway were identified. NF1 most frequent (n = 21, 33%). Recurrent...
Skin cancers are known for their strong immunogenicity, which may contribute to a high treatment efficacy of immune checkpoint inhibition (ICI). However, considerable proportion patients with skin cancer is immuno-compromised by concomitant diseases. Due previous exclusion from clinical trials, the ICI poorly investigated in these patients. The present study analyzed outcome advanced hematological malignancy.This retrospective multicenter included who were treated locally or metastatic...
While immune checkpoint inhibitors (ICIs) in combination with radiotherapy (RT) are widely used for patients brain metastasis (BM), markers that predict treatment response combined RT and ICI (RT-ICI) their optimal dosing sequence the best immunogenic effects still under investigation. The aim of this study was to evaluate prognostic factors therapeutic outcome compare concurrent non-concurrent RT-ICI. We retrospectively analyzed data 93 319 BMs different cancer types who received PD-1 at...
Tebentafusp has recently been approved for the treatment of metastatic uveal melanoma (mUM) after proving to have survival benefits in a first-line setting.This retrospective, multicenter study analyzed outcomes and safety tebentafusp therapy 78 patients with mUM.Patients treated had median PFS 3 months (95% CI 2.7 3.3) OS 22 10.6 33.4). In contrast published Phase study, our cohort higher rate elevated LDH (65.4% vs. 35.7%) included prior systemic local ablative therapies. following ICI,...
Background Despite the availability of effective systemic therapies, a significant number advanced melanoma patients develops brain metastases. This study investigated differences in incidence and time to diagnosis metastasis survival outcomes dependent on type first-line therapy. Methods Patients with metastatic, non-resectable (AJCCv8 stage IIIC–V) without at start therapy (1L-therapy) were identified from prospective multicenter real-world skin cancer registry ADOREG. Study endpoints...
AIM: To elucidate the role of p53 tumour suppressor gene in pathogenesis lip cancer. METHODS: Expression was evaluated immunocytochemically a retrospective study formalin fixed, paraffin wax embedded tissue. Five cases each four types lesions were studied; these comprised squamous cell carcinoma (SCC), solar keratosis (SK), chronic hyperplastic candidosis (CHC), and lichen planus (LP). normal mucosa, SCC, SK from sun exposed facial skin as well LP, CHC, SCC buccal mucosa also analysed....
Despite of various therapeutic strategies, treatment patients with melanoma brain metastasis (MBM) still is a major challenge. This study aimed at investigating the impact type and sequence immune checkpoint blockade (ICB) targeted therapy (TT), radiotherapy, surgery on survival outcome MBM.We assessed data 450 collected within prospective multicenter real-world skin cancer registry ADOREG who were diagnosed MBM before start first non-adjuvant systemic therapy. Study endpoints...
Abstract Necrobiosis lipoidica is a rare granulomatous disorder of the skin. In up to 30% affected patients it can lead ulcerations, which impair quality life and are also very difficult treat. Its pathogenesis not fully understood. Only few studies focussing on necrobiosis be found, but none them focus ulcerated lipoidica. Therefore, we collected demographic data comorbidities assessed treatment options for with Data who were treated in wound care centre University Hospital Essen over past...
Chronic graft-versus-host disease (cGVHD) is a common side effect of allogeneic stem cell transplantation and major cause morbidity mortality in affected patients. Especially skin, eyes oral mucosa are affected. This can lead to pain functional impairment. Extracorporeal photopheresis (ECP) an effective immunomodulatory therapy with minimal effects but its mode action still largely unknown. The objective the present study was examine ECP on neutrophil granulocytes patients cGVHD. Analysis...
2518 Background: N (ABT-263) is a first-in-class orally available Bcl-2 protein inhibitor that in vitro and vivo potentiates D activity across variety of solid tumor types. This phase I study was performed to determine the maximum tolerated dose (MTD) assess safety PK profile plus D. Methods: Pts with advanced tumors, adequate organ function ECOG performance status ≤1 were eligible. at 150 200 mg given PO, QD days (d) 1-3 or d1-5 q21 followed by 75 mg/ m2 IV on d 1 q21. To compare either...
P2X(3) and P2X(2+3) receptors are present on sensory neurons, where they contribute not only to transient nociceptive responses, but also hypersensitivity underlying pathological pain states elicited by nerve injuries. Increased signalling through may arise from an increased routing the plasma membrane and/or gain of function pre-existing receptors. An obvious effector mechanism for functional modulation is protein kinase C (PKC)-mediated phosphorylation, since all P2X family members share a...
Recent technical progress makes sophisticated noninvasive imaging methods available for murine models. For the first time, in this study, we applied fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT and FDG-PET-MRI to a orthotopic model of head neck cancer immunotherapy.Tumor growth floor mouth tumors was evaluated by multimodal small-animal using FDG-PET-CT FDG-PET-MRI. The immunotherapeutic effects anti-CD137 antibody therapy were examined on body weight, tumor growth,...