A5010365237- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Complications and Syndromes
- Immune Response and Inflammation
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Liver physiology and pathology
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Brain Metastases and Treatment
- Soft tissue tumors and treatment
- Adrenal and Paraganglionic Tumors
- CNS Lymphoma Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Ear and Head Tumors
- Glycosylation and Glycoproteins Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Tissue Engineering and Regenerative Medicine
- Neurological and metabolic disorders
- Nanoplatforms for cancer theranostics
- Vasculitis and related conditions
- Immunodeficiency and Autoimmune Disorders
Medizinische Hochschule Hannover
2021-2025
German Center for Lung Research
2025
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2024
Lungenklinik Köln-Merheim
2023
University Hospital Cologne
2022-2023
Ludwig-Maximilians-Universität München
2015-2022
University of Cologne
2022
Children's Hospital
2019
University of Oslo
2018
Goethe University Frankfurt
2018
Objective— Ischemia–reperfusion (I/R) injury significantly contributes to organ dysfunction and failure after myocardial infarction, stroke, transplantation. In addition its established role in the fibrinolytic system, plasminogen activator inhibitor-1 has recently been implicated pathogenesis of I/R injury. The underlying mechanisms remain largely obscure. Approach Results— Using different vivo microscopy techniques as well ex analyses vitro assays, we identified that rapidly accumulates on...
Hintergrund: Seit Sommer 2024 empfiehlt das RKI die passive Immunisierung von Neugeborenen und Säuglingen mit Nirsevimab zur Prävention schwerer RSV-Infektionen im ersten Lebensjahr. Public-Health-Effekte sind nur bei einer breiten Anwendung der Prophylaxe zu erwarten. Bisher liegen keine Daten Awareness für RSV assoziierten Erkrankung sowie Akzeptanz Eltern in Deutschland vor.
While immune checkpoint inhibitors (ICIs) in combination with radiotherapy (RT) are widely used for patients brain metastasis (BM), markers that predict treatment response combined RT and ICI (RT-ICI) their optimal dosing sequence the best immunogenic effects still under investigation. The aim of this study was to evaluate prognostic factors therapeutic outcome compare concurrent non-concurrent RT-ICI. We retrospectively analyzed data 93 319 BMs different cancer types who received PD-1 at...
Programmed necrosis (necroptosis), a newly discovered form of cell death, is mediated by receptor-interacting protein 1 (RIP1) and plays pivotal role after myocardial, renal, cerebral ischemia-reperfusion (I/R). The relevance necroptosis in the postischemic liver remains, however, unclear. aim this study was to analyze programed during hepatic I/R. C57BL6 mice were subjected warm I/R (90 min/240 min). animals pretreated with either RIP1 inhibitor necrostatin-1 (Nec-1, 3.5 μg kg−1) or vehicle...
Abstract T-cells have been demonstrated to modulate ischemia–reperfusion injury (IRI) in the kidney, lung, liver, and intestine. Whereas most T-cell subpopulations contribute primarily antigen-specific effector memory phases of immunity, γδ-T-cells combine adaptive features with rapid, innate-like responses that can place them initiation phase immune reactions. Therefore, we aimed clarify role intestinal IRI. Adult wild-type (WT) γδ- T-cell-deficient mice were subjected acute Gene expression...
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infection in infants. Globally, RSV responsible for approximately 3.2 million hospital admissions and about 60,000 in-hospital deaths per year.Infection with RespIratory Syncytial Virus (IRIS) an observational, multi-centre study enrolling infants severe healthy controls. Inclusion criteria are age between 0 36 months hospitalisation due to at three German sites. Exclusion premature birth, congenital...
This study aims to evaluate the long-term efficacy and reintervention rate after primary percutaneous portal vein stent angioplasty for stenosis (PVS) in pediatric liver transplantation (LT) recipients. From 2004 2020, a total of 470 LTs were performed our center. All cases screened interventional PVS treatment analyzed retrospectively. We identified 44 patients with 46 angioplasties posttransplantation PVS. The median interval from LT catheter intervention was 5 months (16 days-104 months)...
CD4+ T cells recruited to the liver play a key role in pathogenesis of ischemia/reperfusion (I/R) injury. The mechanism their activation during alloantigen-independent I/R is not completely understood. We hypothesized that liver-resident dendritic (DCs) interact with postischemic and modulation DCs or T-cell-DC interactions attenuates inflammation. In mice, warm hepatic (90/120-240 min) was induced. Tolerogenic were generated situ by pretreatment animals vitamin D analog paricalcitol. A...
IgA vasculitis/Henoch-Schoenlein purpura (IgAV/HSP) is a systemic small vessel vasculitis of unknown pathogenesis predominantly affecting children. While skin, GI tract, joints, and kidneys are frequently affected considered, central nervous system (CNS) involvement this disease underestimated.
Background: Veno-venous extracorporeal membrane oxygenation (vv-ECMO) offers a temporary support for patients with acute respiratory failure. However, recirculation of oxygenated blood between cannulas reduces vv-ECMO efficiency and oxygen delivery. This study investigated main variables determining in bench model applying two distinct cannulation strategies (two-site single-lumen [SLC] vs. bicaval dual-lumen [DLC])
Hintergrund Die primäre ziliäre Dyskinesie (PCD) ist eine seltene genetische Erkrankung, die durch gestörte Clearance der Atemwege gekennzeichnet ist. Ein diagnostischer Goldstandard fehlt, aktuelle Diagnostikempfehlung ERS sieht Stufendiagnostik vor. Diese basiert auf ggf. wiederholten Zilienfunktionsuntersuchung (Hochgeschwindigkeits-Videomikroskopie, HSVM) bzw. ultrastrukturellen Analyse mittels Transmissionselektronenmikroskopie (TEM) anhand von Bürstenbiopsien des Atemwegsepithels....
Introduction The "endolymphatic sac tumor" (ELST) - a rare malignant papillary adenomatous neoplasm originating in the saccus or ductus endolymphaticus
Einleitung Der "endolymphatic sack tumor" (ELST) – eine seltene maligne papillär-adenomatöse Neoplasie mit Ursprung im Saccus oder Ductus endolymphaticus
Coronavirus disease 2019 (COVID-19) in children is rarely severe. However, severe courses occur, especially the presence of risk factors. A minority develop pediatric inflammatory multisystem syndrome (PIMS) with substantial morbidity. While importance cardiac involvement after PIMS well established, its role acute COVID-19 remains unclear. We aim to compare sequelae using MRI and them patients PIMS.For this prospective cohort study, we recruited COVID or a single center. Clinical follow-up,...
Introduction: The chemokine fractalkine (CX3CL1) is critically involved in the pathophysiology of different inflammatory diseases and myocardial ischemia-reperfusion (I/R). This study aimed to analyze role CX3CL1 activation platelets leukocytes during hepatic I/R. Methods: Under inhalation anesthesia, C57BL6 mice were subjected warm I/R (90 min/240 min). animals pretreated either with a function-blocking anti-mouse antibody or IgG control administered systemically before ischemia....
CD4+T cells recruited to the liver play a key role in pathogenesis of ischemia/reperfusion (I/R) injury. The mechanism their activation during alloantigen-independent I/R remains unclear. We hypothesized that liver-resident dendritic (DCs) interact with postischemic and modulation DCs or T cell-DC-interactions attenuates inflammation.
Ziel Beschreibung einer seltenen Ursache für eine idiopathische, periphere Fazialisparese Methode: Durchsicht der Patientenakte und Literaturrecherche
Results A 32-year-old female patient presented to our ENT department with right-sided mimic muscle failure. Two days prior presentation department, the had given birth. On following day of delivery, she noted unilateral failure her right side musculature during video telephony. In terms previous diseases, only Hashimoto’s thyroiditis. Cranial nerve examination revealed peripheral facial palsy a House-Brackmann score III. Sonographic imaging parotid gland was without pathologic findings....
Die IgA-Vaskulitis (IgAV; ehem. Purpura-Schönlein-Hennoch) ist eine Immunkomplex-vermittelte Vaskulitis der kleinen Gefäße mit einer Inzidenz von etwa 20 pro 100 000 Kindern Jahr und damit die häufigste bei [1], [2]. Hälfte betroffenen Patienten jünger als 6 Jahre nur 10 % sind älter [3]. IgAV kann jedoch auch Erwachsenen auftreten. Das männliche Geschlecht im Vergleich zum weiblichen doppelt so häufig betroffen Entzündung durch Ablagerung Immunkomplexen in den Gefäßwänden gekennzeichnet....