A5017129984- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Pelvic floor disorders treatments
- Cancer and Skin Lesions
- Head and Neck Surgical Oncology
- Facial Nerve Paralysis Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Otolaryngology and Infectious Diseases
- Ureteral procedures and complications
- Salivary Gland Disorders and Functions
- Urological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Urinary Bladder and Prostate Research
- Soft tissue tumors and treatment
- Social Media in Health Education
- Reconstructive Surgery and Microvascular Techniques
- Venous Thromboembolism Diagnosis and Management
- Tumors and Oncological Cases
- Proteoglycans and glycosaminoglycans research
- Adrenal and Paraganglionic Tumors
- Head and Neck Anomalies
- Urinary and Genital Oncology Studies
University of Cologne
2021-2025
University Hospital Cologne
2022-2024
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2022-2024
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
2024
Klinik für Frauenheilkunde
2007-2024
Klinikum rechts der Isar
2018-2024
Olgahospital
2024
Centrum für Integrierte Onkologie
2024
Lungenklinik Köln-Merheim
2022-2023
University Hospital Augsburg
2020-2022
Abstract Purpose Ultrasound-guided fine-needle aspiration cytology (FNAC) is a widely used diagnostic procedure which facilitates the differentiation of salivary gland lesions. Although performance FNAC (SG-FNAC) has improved since introduction Milan System for Reporting Salivary Gland Cytopathology (MSRSGC), range reported still wide. Therefore, aim this study was to determine lesion- and sampling-related factors that influence success SG-FNAC. Methods All SG-FNAC cases performed in...
Zusammenfassung Ziel dieser Untersuchung war es, die Repräsentation von Frauen in der deutschsprachigen wissenschaftlichen Publikationslandschaft HNO-Heilkunde zu untersuchen. Die Autor*innenschaft wurde anhand Artikeln überprüft, zwischen 2013 und 2023 den 2 größten HNO-Fachzeitschriften (Laryngo-Rhino-Otologie, HNO) veröffentlicht wurden, um Häufigkeit prozentualen Anteil des Geschlechts bei Erst- Letztautor*innenschaft ermitteln. Insgesamt wurden 2631 Artikel untersucht. Bei 699 (26,6%)...
Subgroups with a poorer prognosis exist among patients human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC). This study aims to identify histological and genetic differences within HPV-positive OPSCC correlate these findings patient outcomes. The included 102 patients, all tested for high-risk HPV DNA p16INK4a expression. Based on histomorphological classification (HPV Prediction Classification, PC), cases were categorized as either classic (cHPV) or...
We report our experience concerning clinical and paraclinical features of multiple sclerosis in 19 children. The disease was highly variable its presentation but acute episodes retrobulbar optic neuritis or transverse myelitis cerebellitis were commonly observed at the onset. Diagnosis very often suspected as soon first episode when there evidence more than one lesion (43%) study cerebrospinal fluid demonstrated a local secretion immunoglobulins (60%). Evoked potential studies nuclear...
Background Lack of evidence contributes to unnecessary variation in treatment costs and outcomes. This study aimed identify from interventions historically used for total knee or hip arthroplasty (TKA, THA): i) if routine use is supported by high-level evidence; ii) whether surgeon aligns with the evidence. Methods Part 1: Systematic search electronic library databases systematic reviews practice guidelines concerning seven acute-care interventions. Intervention-specific recommendations were...
The aim of this project was to provide an overview the epidemiology primary salivary gland carcinomas (SGC) in terms incidence, distribution clinicopathological features and survival one largest cancer registries Europe.Data were collected from patients with SGC major glands registered population-based state registry (Landeskrebsregister LKR) North Rhine-Westphalia (NRW), Germany 01/01/2009 12/31/2018. Age standardization incidence performed relative estimates computed by sex, histological...
The incidence of salivary duct carcinoma (SDC) seems to be underestimated due inaccurate classification. Further, the frequency SDC patients with targeted therapy options according current guidelines is unclear. Therefore, this study aimed at (a) describing proportion among gland (SGC) before and after reclassification cases initially classified as adenocarcinoma, not otherwise specified (ANOS); (b) quantifying options.
Proximal humeral fractures are with an incidence of 4–5 % the third most common in elderly. In 20 there is indication for surgical treatment according to modified Neer-Criteria. A secondary varus dislocation head fragment and cutting-out complications angle stable locking plates AO11-A3 One possibility increase stability screw-bone-interface cement augmentation screw tips. second use a multiplanar stablentramedullary nail that might provide better biomechanical properties after fixation...
Abstract Objectives Long‐term prospective studies on procedure‐related complications after parotid surgery for benign neoplasms (BNs) are scarce. This is the first study use of extracapsular dissection (ECD) BNs, and it aimed to examine incidence postoperative BN. Methods We collected data obtained in a parotidectomy BN at university hospital analyzed transient long‐term complications. Results The rates facial palsy immediately 18 months were 15.0% 3.7%, respectively. immediate patients who...
Correct diagnosis of a parotid neoplasm based on histology preoperatively is utmost importance in order to guide patient management. The aim this study was evaluate the diagnostic accuracy an ultrasound-guided core needle biopsy lesion and describe associated post-procedural complications. A retrospective conducted between January 2015 March 2021 all patients who were referred tertiary care center for evaluation underwent due high-risk features or when malignancy suspected clinical...
The aim of this study was to evaluate the quality and educational content YouTube videos showing parotidectomy.We searched for displaying parotidectomy on YouTube. To rate videos, we introduced "Instructional Videos in Otorhinolaryngology by YO-IFOS (IVORY)-grading-system (GS)" derived from IVORY Guidelines, which pose established consensus recommendations production surgical otolaryngology. were rated using IVORY-GS, total score tested statistical association with views, likes,...
Abstract Many locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin , an antibody–drug conjugate binding to Nectin-4, recently gained FDA approval for third-line urothelial carcinoma. Therefore, the aim of this study was assess expression Nectin-4 in primary SGC corresponding lymph node metastases correlate it with clinicopathological data. Immunohistochemical staining performed patients who had undergone surgery curative intent parotid...
Introduction Fine needle aspiration (FNA) of a tumor is an important preoperative method used for cytological sampling in practice. Due to its easy application, cost-effectiveness, crucial diagnostic value, and minimal complications, it can be applied as standard salivary gland tumors ENT clinics. Its greatest benefit lies differentiating between malignant benign findings guide treatment decisions.
Therapeutic options for advanced salivary gland cancer (SGC) are rare. Therefore, it was the aim of this study to investigate extent and intensity Mucin-1 (MUC1), Mucin-16 (MUC16), Mucin-5AC (MUC5AC) as potential molecular targets using immunohistochemistry. The medical records all patients who underwent primary surgery with curative intent in a tertiary referral center between 1990 2018 were reviewed. Immunohistochemical staining MUC1, MUC16, MUC5AC performed sufficient formalin-fixed...
Advanced salivary gland carcinomas (SGC) often lack therapeutic options. Agents targeting CD138 have recently shown promising results in clinical trials for multiple myeloma and a preclinical trial triple-negative breast cancer. Immunohistochemistry was performed all patients who had undergone primary surgery SGC with curative intent. Findings were validated using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) imaging. Overall, 111 13 lymph node metastases from duct...
Objective This study aimed to analyze the educational quality and content of septoplasty videos on YouTube validate "Instructional Videos in Otorhinolaryngology by YO-IFOS-Grading-System" (IVORY-GS.
Einleitung Diese Studie zielte darauf ab, die didaktische Qualität und den Inhalt von Septumplastik-Videos auf YouTube zu analysieren das "Instructional Videos in Otorhinolaryngology by YO-IFOS-Grading-System" (IVORY-GS) validieren.
Introduction The "endolymphatic sac tumor" (ELST) - a rare malignant papillary adenomatous neoplasm originating in the saccus or ductus endolymphaticus
Background Therapeutic options in recurrent/metastatic salivary gland carcinoma (SGC) are scarce. Enfortumab vedotin, a nectin-4-binding antibody-drug conjugate, was recently approved by the FDA and EMA for third-line treatment of urothelial carcinoma.