A5078832851- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Cervical Cancer and HPV Research
- Cancer Immunotherapy and Biomarkers
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Cancer-related molecular mechanisms research
- Dysphagia Assessment and Management
- Medical Imaging and Pathology Studies
- Voice and Speech Disorders
- AI in cancer detection
- Radiopharmaceutical Chemistry and Applications
- Ear Surgery and Otitis Media
- Brain Metastases and Treatment
- Oral and Maxillofacial Pathology
- Otolaryngology and Infectious Diseases
- Muscle and Compartmental Disorders
- Teratomas and Epidermoid Cysts
- Hematological disorders and diagnostics
Justus-Liebig-Universität Gießen
1995-2025
Universitätsklinikum Gießen und Marburg
2019-2024
Hals- Nasen- und Ohrenklinik Gießen
2022-2024
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2018-2023
Klinikverbund Südwest
2020
Giessen School of Theology
2020
Universitätsmedizin Göttingen
2010
University of Pennsylvania
2009
University of Göttingen
2003-2004
Tulane Medical Center
2001
Abstract Purpose: Human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC) is tumorigenic and has been associated with a favorable prognosis compared OPSCC caused by tobacco, alcohol, other carcinogens. Meanwhile, machine learning evolved as powerful tool to predict molecular cellular alterations of medical images various sources. Experimental Design: We generated deep learning–based HPV prediction score (HPV-ps) on regular hematoxylin eosin (H&E) stains assessed its...
Subgroups with a poorer prognosis exist among patients human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC). This study aims to identify histological and genetic differences within HPV-positive OPSCC correlate these findings patient outcomes. The included 102 patients, all tested for high-risk HPV DNA p16INK4a expression. Based on histomorphological classification (HPV Prediction Classification, PC), cases were categorized as either classic (cHPV) or...
Tumor growth and survival requires a particularly effective immunosuppressant tumor microenvironment (TME) to escape destruction by the immune system. While immunosuppressive checkpoint markers like programmed cell death 1 ligand (PD-L1) are already being targeted in clinical practice, lymphocyte-activation-protein 3 (LAG-3), T-cell immunoglobulin mucin-domain containing-3 (TIM-3) V-domain Ig suppressor of T activation (VISTA) inhibitors currently under investigation trials. Reliable...
Abstract Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) represents an OPSCC subgroup with overall good prognosis a rising incidence in Western countries. Multiple lines of evidence suggest that HPV-associated tumors are not homogeneous tumor entity, underlining the need for accurate prognostic biomarkers. In this retrospective, multi-institutional study involving 906 patients from four centers and one database, we developed deep learning algorithm...
Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other entities have revealed differences treatment response and prognosis. However, limited data OPSCC according to gender human papillomavirus (HPV) status exist. Therefore, we aimed investigate sex-specific how these may be distributed relation HPV risk factors.This retrospective, bicentric study included 1629 patients diagnosed...
6006 Background: Randomized trials and meta-analyses have demonstrated therapeutic superiority for concurrent platinum-based chemoradiation vs. RT alone in unresectable LA-SCCHN. More recently, Bonner et al (NEJM, 2006) reported a survival advantage (C) plus vs alone. We report toxicity response data from an ECOG trial of chemo-RT C Methods: Unresectable, newly diagnosed patients with LA-SCCHN, PS 0–1 adequate physiologic indices received 400 mg/m2 d1, then 250 Q wk, combination definitive...
The oncogenic human papillomaviruses (HPV) types 16 and 18 contribute to more than 73% cases of all HPV-related cancers commonly affect the anogenital head neck region, with rapidly rising incidence rates oropharyngeal squamous cell carcinomas (OPSCC). HPV vaccination has potential decrease burden disease, but remain low in many countries. We investigated level awareness HPV, HPV-OPSCC particular, a representative sample German population.As part an online, population-based survey,...
Abstract Patients with HPV‐driven (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) have a significantly improved overall survival compared to patients HPV‐negative (HPV−) OPSCC. Nevertheless, 13%–25% of HPV+OPSCC develop local/distant recurrence (LDR) and course disease similar HPV−OPSCC. We hypothesize that HPV+OPSCCs LDR mutation frequency pattern HPV−OPSCCs, which is associated severe outcome. performed targeted next‐generation sequencing using customized gene panel data from 56...
Human papillomavirus (HPV) status is the most important predictor of survival in oropharyngeal squamous cell carcinoma (OPSCC). In patients with cervical lymph node metastases unknown origin (CUPHNSCC), much less known.We assessed a consecutive cohort CUPHNSCC diagnosed from 2000-2018 for HPV DNA, mRNA, p16INK4a (p16) expression, and risk factors to identify prognostic classification markers.In 32/103 (31%) CUPHNSCC, p16 was overexpressed, high-risk DNA detected 18/32 (56.3%). This mostly...
Purpose: Early glottic cancer is a highly curable malignancy. Disease control achieved by resec-tion or external beam radiation with similar long-term results according survival. Surgery predominantly performed transoral endoscopic approach, due to reduced complication rates when compared open cordectomy. Open cordectomy might still be warranted in cases of inad-equate surgical accessibility. Aim the present study was compare versus approach relation complications and outcome an up-to-date...
Surgery and radiotherapy are current therapeutic options for malignant tumors involving the nasal vestibule. Depending on location, organ-preserving resection is not always possible, even small tumors. Definitive an alternative as procedure. Carbon ion beam offers highly conformal dose distributions more complex biological radiation effects eventually resulting in optimized normal tissue sparing improved outcome. The aim of study was to analyze toxicity, local control (LC), organ preserving...
5563 Background: Conventional dosing of C (400 mg/m2 loading dose, 250 weekly) yields response rate approximately 13% among pts with R/M HNSCC. weekly may not saturate EGFR adequately (Clin Cancer Res 7:1204), and can be inconvenient for pts. safely administered every 2 weeks (Q2W) at high doses (between 400 700 mg/m2) metastatic colorectal cancer (Ann Oncol 21: 1537). We sought to evaluate dose given Q2W patients Methods: This multicenter prospective phase II study randomized (≤2 prior...
Zusammenfassung Die Sialolithiasis als eine der häufigsten Speicheldrüsenerkrankungen betrifft die Glandula submandibularis im Vergleich zur parotis deutlich häufiger. Im Verlauf Erkrankung kommt es in vielen Fällen zu rezidivierenden Sialadenitiden. Durch verbesserte Diagnostik besteht neben Submandibulektomie auch Möglichkeit einer drüsenerhaltenden Therapie, z. B. mittels Miniaturendoskopie (Sialendoskopie).
6532 Background: Nivolumab has demonstrated efficacy in clinical trials of recurrent or metastatic squamous cell carcinoma the head and neck (R/M SCCHN). As only limited real-world data are available, we describe use nivolumab its outcomes routine practice. Methods: HANNA is a prospective, observational study patients with R/M SCCHN treated 56 hospitals practices Germany. In total, 385 will be followed for ≤ 5 years from treatment initiation until death, withdrawal consent, loss...
The two pillars of therapy for oropharyngeal squamous cell carcinoma (OPSCC) are upfront surgery and primary chemoradiotherapy. Substantial regional preferences exist with regard to the selection treatment. Despite new therapeutic approaches, patient survival remains poor, an approximate overall (OS) rate 50% at five years. This study was conducted investigate a potential benefit depending on treatment modality in OPSCC patients. We retrospectively collected data 853 patients histologically...
Recurrent Respiratory Papillomatosis (RRP) is a rare infectious disease of the upper aerodigestive tract caused by human papillomavirus (HPV). Virus subtypes 6 and 11 are found in most papillomas, type associated with severe course. There juvenile an adult form defined age initial manifestation. The shows more course according to number surgical interventions secondary malignancy. A variety treatment modalities used treat RRP. Baseline therapy via microlaryngoscopical approach. Extended...
Background After radiotherapy of a tumour the upper aerodigestive tract (HNSCC), many patients suffer from increased fatigue and sleepiness. Unrecognised sleep apnoea can be considered as possible cause. Radiotherapy is known to lead fibrotic tissue changes post-radiogenic oedema. in head neck area results an anatomical functional change airway with obstruction or narrowing breathing-relevant structures. The aim study determine prevalence obstructive (OSA) after curative aerogigestive tract.
Hintergrund Nach Radiotherapie eines Tumors des oberen Aerodigestivtraktes (HNSCC) leiden viele Patienten unter verstärkter Müdigkeit und Schläfrigkeit. Eine unerkannte Schlafapnoe kann als mögliche Ursache in Betracht gezogen werden. Es ist bekannt, dass die Strahlentherapie zu einer fibrotischen Gewebsveränderung postradiogenen Ödemen führt. Die im Kopf-Hals-Bereich resultiert anatomischen funktionellen Veränderung Atemweges mit möglicher Verlegung oder Verengung atemrelevanter Strukturen....
Several immunological parameters have been proposed as prognostic indicators for squamous cell carcinomas of head and neck, potentially contributing, alongside conventional UICC classification, to the assessment disease progression survival prognosis. Aim this study is investigate level CRP a factor overall patients with neck carcinoma. Data were collected from all treated at ENT Clinic University Hospital in Giessen, Germany between 2009 2020. The date diagnosis, pretherapeutic level,...
Einleitung Bis zu 25% der Patienten mit einem HPV-positiven Oropharynxkarzinom (HPV+OPSCC) entwickeln ein Rezidiv. Biomarker zur frühzeitigen Identifikation dieser Subkohorte fehlen. Ziel Studie war es Transkriptom (mRNA)-basiertes Expressionsprofil identifizieren, welches Entwicklung eines Rezidivs bei HPV+OPSCC in Zusammenhang steht.
Introduction The PD-L1-related immune escape of head and neck tumor cells is known as a mechanism proliferation, but the increased expression PD-L1 in appears to be prognostic factor dependent on entity. Accordingly, relevance squamous cell carcinoma (HNSCC) has not been clearly clarified. In particular, question homogeneity marker within comparison metastasis arises.
Der PD-L1-bedingte Immun-Escape von Kopf-Hals-Tumorzellen ist als Mechanismus der Tumorproliferation bekannt, die vermehrte Expression PD-L1 im Tumor scheint prognostischer Faktor jedoch abhängig Tumorentität zu sein. Entsprechend Relevanz Kopf-Hals-Plattenepithelkarzinom (HNSCC) nicht eindeutig geklärt. Insbesondere stellt sich Frage Homogenität Markers innerhalb des Tumors und Vergleich Metastasierung. An einer Patientengruppe 30 Patienten mit einem metastasierten Plattenepithelkarzinom...
Mehrere immunologische Parameter wurden in den letzten Jahren als Prognosemarker bei Kopf- und Hals-Karzinomen vorgeschlagen könnten somit neben der herkömmlichen UICC-Klassifikation zur Beurteilung Überlebensprognose beitragen. Ziel Studie ist die Untersuchung des CRP-Wertes prognostischen Faktor für das Gesamtüberleben von Patienten mit Hals-Karzinomen. Es eingeschlossen, HNO-Abteilung Universitätsklinikums Gießen im Zeitraum 2009 bis 2020 behandelt wurden. Diagnosedatum,...
Introduction Up to 25% of patients with HPV-positive oropharyngeal carcinoma (HPV+OPSCC) develop recurrence. Biomarkers for the early identification this subcohort are missing. The aim study was identify a transcriptome (mRNA)-based expression profile associated development recurrence in HPV+OPSCC.
Abstract Background Highflow nasal cannula oxygen (HFNO) is known to be used for noninvasive oxygenation in intensive care patients but it has rarely been airway management elective surgery of the upper aerodigestive tract. Objectives HFNO offers opportunities a tubeless system which easy handle and not limited only on endolarynx. Methods We evaluated this method during brief interventional procedures larynx pharynx 92 adult safety intraoperative complications. The need secondary...