A5021962736- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Tracheal and airway disorders
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Facial Nerve Paralysis Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Cervical Cancer and HPV Research
- Head and Neck Anomalies
- Vestibular and auditory disorders
- Tumors and Oncological Cases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Airway Management and Intubation Techniques
- Obstructive Sleep Apnea Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
Klinikum Dortmund
2020-2024
Justus-Liebig-Universität Gießen
2014-2023
Witten/Herdecke University
2022-2023
Universitätsklinikum Gießen und Marburg
2012-2021
Kreiskrankenhaus Dormagen
2020
Hospital de Sant Pau
2019
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde
2002-2018
Medical University of Vienna
2003-2018
Jena University Hospital
2008-2014
University of Cologne
2000-2013
The objective of this study was to analyze the perioperative and long-term complications after standardized lateral total parotidectomy for benign parotid tumors chronic parotitis with special regard on training skill surgeons at a university teaching center. All operations were performed under strict microscopic control supervision experienced surgeons.The authors conducted retrospective unicentric in tertiary center.Medical records 963 parotidectomies treated from 1986 2004 analyzed...
The purpose of this study was to test whether the 8th edition AJCC/UICC TNM staging system (UICC) precisely differentiates between stages and reflects disease outcome in human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC).OPSCC patients that were diagnosed 2000 2016 included analysis HPV status determined by combined DNA p16 testing. Stratification done according 7th UICC rules. Incidence trends HPV-associated tumorigenesis, 5-year overall survival (OS) tumor...
Increasing incidences of head and neck cancers rising proportions these associated with human papillomavirus (HPV), especially in the oropharynx, have been reported international studies. So far, trends contribution HPV to number newly diagnosed cases oropharyngeal squamous cell carcinomas (OPSCC) Germany are uncertain. We investigated association incidence rates a cohort consecutively included patients OPSCC Giessen 2000-2017, compared our results regional (Giessen federal state Hesse),...
Surgery for recurrent parotid pleomorphic adenoma is a challenging problem.One hundred eight patients who underwent 134 reoperations (follow-up, 22 years) were evaluated histopathologic features and risk factors recurrence.The number of tumor recurrence ranged from 1 to 10. Twenty-seven (25%) developed permanent facial nerve weakness. The risks clinically evident rerecurrence after 1, 5, 15 years 16%, 42%, 75%, respectively. Female sex, young age at initial treatment, enucleation instead...
Abstract Objectives/Hypothesis: To analyze the benefit of electromyographic (EMG) neuromonitoring during primary surgery on benign parotid lesions for postoperative facial function compared to visual observation only. Study Design: Prospective controlled clinical two‐center trial. Methods: Using an operation microscope, 100 parotidectomies in 96 patients were performed: 50 procedures with a continuous EMG monitoring plus (EMG group), and only control (control group). The rate weakness was...
Abstract Objectives: To compare the prognostic value of electroneurography (ENG) and needle electromyography (EMG) to estimate facial function outcome after acute palsy. Study Design: Retrospective study using electrodiagnostic data medical chart review. Methods: Two hundred one patients treated 1995 2004 were included. Initial final was established clinically by House‐Brackmann (HB) scale. ENG results classified into amplitude loss less than 75% or greater predict complete recovery...
Human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx (OSCC) are clinical and biological distinct from their HPV-unrelated counterparts. Patients with HPV-related OSCC display improved prognosis therefore we investigated possible immune infiltrations associated this tumor phenotype. We retrospectively analyzed a randomly selected cohort 140 for presence cells HPV by immunohistochemistry PCR followed bead-based hybridization (Luminex technology). prevalence was 24.3% as...
Upfront surgery is a valuable treatment option for oropharyngeal squamous cell carcinoma (OPSCC) and risk stratification emerging de-escalation in human papillomavirus (HPV)-related OPSCC. Available prognostic models are either based on selected, mainly non-surgically treated cohorts. Therefore, we investigated unselected OPSCC with predominantly upfront surgery.All patients diagnosed curative intent between 2000 2009 (n=359) were included. HPV association was determined by HPV-DNA detection...
Histopathological characteristics and proliferation indices of recurrent pleomorphic adenoma were described in a series 31 patients who referred to the authors' clinic for revision surgery.Prospective patients.Serial sections surgical specimen using whole-organ sectioning technique carried out light microscopic examination after total parotidectomy periparotid fat resection. The nodules examined with special reference localization, amount, size, histological subtypes, capsular alterations,...
Conclusions. We identified smoking as a significant risk factor for multilocular Warthin tumor development. Therefore, we recommend taking history of into account when making the decisions surgical strategy. Objectives. is common benign neoplasm parotid gland. Risk factors development have not been defined. Patients and methods. A total 185 consecutive patients treated were included. Charts reviewed symptoms, factors, diagnostic procedures. followed facial function recurrence. evaluated....
Head and Neck Squamous Cell Carcinomas (HNSCC) are the 6(th) most common cancers worldwide. While incidence rates for cancer of hypopharynx larynx decreasing, a significant increase in oropharynx (OSCC) is observed. Classical risk factors HNSCC smoking alcohol. It has been shown 25 to 60% OSCC be associated with an infection by oncogenic human papilloma viruses (HPV). The development "common" head neck substantially enhanced accumulation genetic changes, which lead inactivation tumor...
Background The prognostic role of circulating tumor cells (CTCs) after induction chemotherapy using docetaxel, cisplatin and fluorouracil (TPF) prior to surgery adjuvant (chemo)radiation in locally advanced oral squamous cell cancer (OSCC) was evaluated. Methods In this prospective study, peripheral blood samples from 40 patients the phase II study TISOC-1 (NCT01108042) with OSCC before, during, treatment were taken. CTCs quantified laser scanning cytometry anti– epithelial adhesion...
Abstract Background In this exploratory study, employment and psychological factors were investigated in head neck cancer survivors with survivorship of ≥2 years. Methods Fifty‐five ≤60 years old completed a survey including subscales from the Functional Assessment Cancer Therapy (FACT) instrument, Miller Behavioral Style Scale, General Perceived Self‐Efficacy Patient Health Questionnaire‐9 (PHQ‐9), Hornheider–Fragebogen short version (HFB) measuring need for interventions. Exploratory...
p16 INK4a immunohistochemical overexpression is an overall reliable surrogate marker of human papillomavirus (HPV)‐associated head and neck squamous cell carcinomas (HNSCC). However, cases ambiguous are regularly detected in the neck: expression can be observed non‐malignant tissue, such as tonsillar crypt epithelium a proportion branchial cleft cysts. Additionally, diverse patterns INK4 complicate interpretation “p16 ‐positivity”. These aspects impede unrestricted application diagnostic...
Abstract Purpose: Human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OPSCC) is tumorigenic and has been associated with a favorable prognosis compared OPSCC caused by tobacco, alcohol, other carcinogens. Meanwhile, machine learning evolved as powerful tool to predict molecular cellular alterations of medical images various sources. Experimental Design: We generated deep learning–based HPV prediction score (HPV-ps) on regular hematoxylin eosin (H&E) stains assessed its...
Abstract Background A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16 INK4a , a surrogate marker for HPV-driven OPSCC, sufficient correctly identify those tumours and avoid substantial HPV misattribution thus undertreatment patients...
Although suspension laryngoscopy (SL) is routinely used in operative laryngology, no prospectively gathered data on the complications of this procedure have so far been available. We analyzed 339 consecutive procedures for intervention-related complications. The survey included preoperative dental status and assessment postoperative dental, mucosal, nerve injuries. Minor mucosal lesions were found 75% all patients. All healed spontaneously within a few days. Dental injuries occurred 6.5%...
Our recent analysis of papillomavirus (HPV) DNA in different malignant head and neck tumors revealed that HPV infections occurred most frequently tonsillar carcinomas (58%) 84% positive cases contained the highly oncogenic type 16. We could also present data favor hypothesis view their clinical behavior involved risk factors HPV-positive HPV-negative may represent two separate tumor entities. Looking for a surrogate marker, which further epidemiological studies replace laborious expensive...
Background. Carcinoma ex pleomorphic adenoma (CXPA) is a rare parotid malignancy and until today no standardized concept exists for its therapy apart from recommendations carcinoma in general. Prognosis thought to be poorer than other malignancies. We sought describe general diagnostic strategy assess factors predicting the outcome. Methods. retrospectively analysed courses of 22 patients with CXPA gland treated at tertiary medical care centre otorhinolaryngology. examined parameters...
This study reports the oncological outcome of a non-selected series patients with human papillomavirus(HPV)-positive and -negative oropharyngeal squamous cell carcinoma (OSCC) preferentially managed upfront surgery.Consecutive OSCC cases (n = 378) diagnosed from 2000 to 2010 in our department were evaluated for risk factors, HPV association, therapy overall survival (OS). status was determined by combined DNA p16 testing, treatment defined as first course any kind surgery (upfront surgery)...