The current study was conducted to evaluate the long-term results of irradiation with carbon ions in a raster scanning technique patients skull base chordomas.Between 1998 and 2008, total 155 (76 men 79 women) median age 48 years (range, 15 years-85 years) were irradiated using scan technique. performed at Society for Heavy Ion Research Darmstadt, Germany. dose 60 gray (relative biological effectiveness) 3 per fraction. boost planning target volume 70 mL 2 mL-294 mL). Local control (LC)...

BACKGROUND The current study was performed to evaluate the safety and effectiveness of irradiation with carbon ions using raster scanning as well prognostic factors in patients skull base chondrosarcomas. METHODS Between 1998 2008, 79 chondrosarcoma were treated scanning. applied median total dose 60 gray equivalent (GyE) at 3 GyE per fraction. Local control overall survival (OS) evaluated Kaplan‐Meier method. Long‐term toxicity quantitatively assessed questionnaires. RESULTS follow‐up after...

Local control in patients with adenoid cystic carcinoma (ACC) of the head and neck remains a challenge because relative radioresistance these tumors. This prospective carbon ion pilot project was designed to evaluate efficacy toxicity intensity-modulated radiotherapy (IMRT) plus (C12) boost (C12 therapy). The authors present first analysis long-term outcomes raster-scanned C12 therapy compared modern photon techniques.Patients inoperable or subtotally resected ACC received within project....

Treatment of local relapse in adenoid cystic carcinoma (ACC) following prior radiation remains a challenge: without the possibility surgical salvage patients face choice between palliative chemotherapy and re-irradiation. Chemotherapy yields response rates around 30% application tumouricidal doses is difficult due to proximity critical structures. Carbon ion therapy (C12) promising method minimize side-effects maximize re-treatment dose this indication. We describe our initial results for...

Chordomas of the skull base are relative rare lesions bones. Surgical resection is primary treatment standard, though complete nearly impossible due to close proximity critical and hence also dose limiting organs for radiation therapy. Level recurrence after surgery alone comparatively high, so adjuvant therapy very important improvement local control rates. Proton gold standard in chordomas. However, high-LET beams such as carbon ions theoretically offer biologic advantages by enhanced...

Chordomas are relatively rare lesions of the bones. About 30% occur in sacrococcygeal region. Surgical resection is still standard treatment. Due to size, proximity neurovascular structures and complex anatomy pelvis, a complete with adequate safety margin difficult perform. A radical margins often leads loss bladder rectal function as well motoric/sensoric dysfunction. The recurrence rate after surgery alone comparatively high, such that adjuvant radiation therapy very important for...

Low and intermediate grade chondrosarcomas are relative rare bone tumours. About 5-12% of all localized in base skull region. chondrosarcoma has a low incidence distant metastasis but is potentially lethal disease. Therefore, local therapy crucial importance the treatment chondrosarcomas. Surgical resection primary standard. Unfortunately late diagnosis at extensive stage common due to slow asymptomatic growth lesions. Consequently, complete hindered close proximity critical hence dose...

Abstract BACKGROUND: The aim of this study was to evaluate efficacy and toxicity radioimmunotherapy with intensity‐modulated radiation (IMRT) cetuximab in stage III nonsmall cell lung cancer (NSCLC). METHODS: NEAR a prospective, monocentric phase II trial including patients unfit for chemoradiation regimen; treatment consisted IMRT weekly followed by 13‐week maintenance period. Primary endpoints were feasibility; secondary remission rates at completion the planned according Response...

Radiation therapy is an essential modality in the treatment of breast cancer. Addition radiotherapy to surgery has significantly increased local control and survival rates disease. However, also associated with side effects, such as tissue fibrosis or enhanced vascular morbidity. Modern strategies, intensity modulated (IMRT), can shorten overall time by integration additional tumor bed boost significantly. To what extent this might be possible without impairing outcome cosmetic results...

Ameloblastic carcinomas are rare odontogenic tumors. Treatment usually consists of surgical resection and sometimes adjuvant radiation. We report the case a 71 year-old male patient undergoing carbon ion therapy for extensive local relapse ameloblastic carcinoma. outcome was favourable with complete remission at 6 weeks post completion radiotherapy while RT-treatment itself tolerated well only mild side effects. High dose radiation hence is potential alternative patients unfit or unwilling...

To report oncological outcomes and toxicity rates, of definitive platin-based chemoradiadiationtherapy (CRT) in the management proximal esophageal cancer. We retrospectively reviewed medical records patients with cT1-4 cN0-3 cM0 cervical cancer (CEC) (defined as tumors located below inferior border cricoid cartilage, down to 22 cm from incisors) treated between 2004 2013 platin–based CRT four Swiss institutions. Acute chronic toxicities were scored using National Cancer Institute's Common...

There are fewer investigations conducted on human primary endometrial epithelial cells (HPEECs) compared to stromal (HPESCs). One of the main reasons is scarcity protocols enabling prolonged cell culture. Even though it possible culture HPEECs in 3D over a longer period time, technically demanding. In this study, we successfully established highly pure, stable, and long-term viable conditionally reprogrammed line, designated as eCRC560. These stained positive for markers, estrogen...

Presenting the initial clinical results in treatment of complex shaped adenoid cystic carcinomas (ACC) head and neck region by inverse planned stereotactic IMRT.25 patients with huge ACC different areas were treated. At time radiotherapy two already suffered from distant metastases. A complete resection tumor was possible only 4 patients. The remaining incompletely resected (R2: 20; R1: 1). 21 received an integrated boost IMRT (IBRT), which allow use single doses for target volumes one...

Chemoradiotherapy for head and neck cancer (SCCHN) is challenging in elderly, multi-morbid patients. Radioimmunotherapy (RIT) with cetuximab provides an option to enhance efficacy of radiotherapy without increased toxicity. We present a single-centre experience RIT these Toxicity outcome was retrospectively analysed patients treated between 2006 2009. Treatment response at first follow-up, estimated using Kaplan-Meier analyses. 73 primary/recurrent SCCHN were (re-irradiation: 22 patients)....

To evaluate the use of high-dose radiotherapy using carbon ions (C12) on non-adenoid cystic malignant salivary gland tumors (MSGT).Between 2009 and 2013, patients with biopsy-proven non-ACC MSGT histologies head neck received a combined regimen IMRT plus C12 boost. Treatment toxicity (CTC v3), response (RECIST 1.1), control survival rates were retrospectively analyzed.40 pathologically confirmed (T4: 45 %; N+: 40 gross residual: 58 mucoepidermoid carcinoma (MEC): adenocarcinoma: 20 %)...

Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensification treatment schedules through introduction novel induction combination chemotherapy regimen altered fractionation regimen, patient tolerance higher intensities is limited accompanying side-effects. Combined radioimmunotherapy with cetuximab as well modern radiotherapy techniques such...

To investigate repositioning accuracy in particle radiotherapy 6 degrees of freedom (DOF) and intensity-modulated (IMRT, 3 DOF) for two immobilization devices (Scotchcast masks vs thermoplastic head masks) currently use at our institution fractionated radiation therapy neck cancer patients.Position verifications patients treated with carbon ion IMRT malignancies were evaluated. Most received combined treatment regimen (IMRT plus boost), was achieved either Scotchcast or masks. Position...