A5085380597- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- AI in cancer detection
- HER2/EGFR in Cancer Research
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Cancer Treatment and Pharmacology
- Digital Radiography and Breast Imaging
- Reconstructive Surgery and Microvascular Techniques
- Ultrasound Imaging and Elastography
- Cytokine Signaling Pathways and Interactions
- Cancer survivorship and care
- Advanced Breast Cancer Therapies
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Digital Imaging in Medicine
- Cancer Risks and Factors
- Ovarian cancer diagnosis and treatment
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
Breast Center
2012-2024
University of Rostock
2024
University Medical Center Hamburg-Eppendorf
2024
University Hospital Ulm
2024
University Hospital and Clinics
2024
Agaplesion Markus Hospital
2024
Universität Hamburg
2024
St. Elisabeth-Hospital Bochum
2024
In recent years, circulating miRNAs have attracted a great deal of attention as promising novel markers for various diseases. Here, we investigated their potential to serve minimally invasive, early detection breast cancer in blood plasma. We profiled extracted from the plasma stage patients (taken at time-point diagnosis) and healthy control individuals using TaqMan low-density arrays (TLDA). Selected candidates identified initial screen were further validated an extended study cohort 207...
Objective: This study aimed to investigate the feasibility and accuracy of non-radioactive TLN biopsy TAD in routine clinical practice. Background Data: involves (TLNB) sentinel lymph node was recently introduced as a new standard for less invasive axillary staging BC patients undergoing neoadjuvant systemic therapy (NST); however, evidence is limited. Methods: The SenTa prospective registry conducted at 50 centers. Patients with who nderwent clip insertion into most suspicious were...
Importance Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from positive to negative neoadjuvant chemotherapy are sparse. Additionally, the best surgical staging technique this scenario is unknown. Objective To investigate sentinel biopsy (SLNB) dual-tracer mapping or targeted (TAD), which combines SLNB localization and retrieval clipped node. Design, Setting, Participants In multicenter retrospective cohort...
The efficacy of fertility awareness based (FAB) methods family planning is critically reviewed. objective was to investigate the and acceptability symptothermal method (STM), an FAB that uses two indicators fertility, temperature cervical secretions observation. This paper will recommend a more suitable approach measure efficacy.Since 1985, ongoing prospective observational longitudinal cohort study has been conducted in Germany. Women are asked submit their menstrual cycle charts record...
Neoadjuvant chemotherapy (NACT) is widely used as an efficient breast cancer treatment. Ideally, a pathological complete response (pCR) can be achieved. Up to date, there no reliable way of predicting pCR. For the first time, we explore ability minimal invasive biopsy (MIB) techniques diagnose pCR in patients with clinical (cCR) NACT this study. This question high relevance because prediction could have direct implications for practice. In all, 164 were included review-board approved,...
Neoadjuvant systemic treatment (NST) elicits a pathologic complete response in 40%-70% of women with breast cancer. These patients may not need surgery as all local tumor has already been eradicated by NST. However, nonsurgical approaches, including imaging or vacuum-assisted biopsy (VAB), were able to accurately identify without residual cancer the axilla. We evaluated feasibility machine learning algorithm (intelligent VAB) exceptional responders NST.We trained, tested, and validated using...
Importance The increasing use of neoadjuvant systemic therapy (NST) has led to substantial pathological complete response rates in patients with initially node-positive, early breast cancer, thereby questioning the need for axillary lymph node dissection (ALND). Targeted (TAD) is feasible staging; however, data on oncological safety are scarce. Objective To assess 3-year clinical outcomes node-positive cancer who underwent TAD alone or ALND. Design, Setting, and Participants SenTa study a...
Our study aims to identify the risk factors and dosimetry characteristics associated with capsular contracture.
To evaluate virtual touch tissue imaging quantification (VTIQ) as a new elastography method concerning its intra- and interexaminer reliability ability to differentiate benign from malignant breast lesions in comparison combination with ultrasound (US) B-mode reporting data system (BI-RADS) assessment. US VTIQ were performed by two examiners 103 women 104 lesions. Intra- of was assessed. The area under the receiver operating curve (AUC), sensitivity, specificity, positive predictive value...
To prospectively assess circulating tumor cell (CTC) status at baseline (CTCBL) and after one cycle of a new line systemic therapy (CTC1C), changes from CTCBL to CTC1C (CTC kinetics, CTCKIN) for their utility in predicting response, progression-free (PFS) overall survival (OS) metastatic breast cancer (MBC). was determined as negative (-) or positive (+) < 5 ≥ CTCs/7.5 ml blood using CellSearch™ (Veridex). CTCKIN categorized favorable (CTC1C-) unfavorable (CTC1C+). Tumor response be assessed...
Objective: We evaluated the ability of minimally invasive, image-guided vacuum-assisted biopsy (VAB) to reliably diagnose a pathologic complete response in breast (pCR-B). Summary Background Data: Neoadjuvant systemic treatment (NST) elicits up 80% women with cancer. In such cases, surgery, gold standard for confirming pCR-B, may be considered overtreatment. Methods: This multicenter, prospective trial enrolled 452 presenting initial stage 1-3 cancer all biological subtypes. Fifty-four...