A5039896134- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Renal and related cancers
- Reconstructive Surgery and Microvascular Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Body Contouring and Surgery
- 3D Printing in Biomedical Research
- Colorectal Cancer Surgical Treatments
- Microfluidic and Bio-sensing Technologies
- Genetic factors in colorectal cancer
- Nuclear Structure and Function
- CRISPR and Genetic Engineering
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Family Support in Illness
University Hospital of Zurich
2019-2025
ETH Zurich
2022-2025
University of Basel
2025
University Hospital of Basel
2025
University of Zurich
2023-2024
Herzgefäss Medizin Klinik Im Park
2021
Charité - Universitätsmedizin Berlin
2011-2012
Johns Hopkins Hospital
1997
Johns Hopkins University
1996
Importance Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from positive to negative neoadjuvant chemotherapy are sparse. Additionally, the best surgical staging technique this scenario is unknown. Objective To investigate sentinel biopsy (SLNB) dual-tracer mapping or targeted (TAD), which combines SLNB localization and retrieval clipped node. Design, Setting, Participants In multicenter retrospective cohort...
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
Abstract Background: Data on the oncologic safety of omission axillary lymph node dissection (ALND) in positive (N+) patients who downstage to ypN0 with neoadjuvant chemotherapy (NAC) is sparse. Additionally, there no consensus which staging procedure should be used this setting, sentinel biopsy (SLNB) alone or combination localization and retrieval clipped node, also known as targeted (TAD). Whether reduction false negative rate observed TAD translates into a significant recurrence unknown....
Background Endocrine therapy is standard of care maintenance treatment for estrogen receptor (ER) positive breast cancers and increasingly used in low-grade serous ovarian cancer. However, its therapeutic role the early setting ER high-grade cancer (HGSC) remains undefined. Methods A retrospective analysis was conducted on clinicopathological data from patients with newly diagnosed HGSC following completion adjuvant chemotherapy. Patients received either or without aromatase inhibitor...
Cancer patients with advanced disease are characterized by intrinsic challenges in predicting drug response patterns, often leading to ineffective treatment. Current clinical practice for treatment decision-making is commonly based on primary or secondary tumour biopsies, yet when progression accelerates, tissue biopsies not performed a regular basis. It this context that liquid may offer unique window uncover key vulnerabilities, providing valuable information about previously...
Prepectoral implant-based reconstruction using synthetic meshes is feasible with good outcomes. We present our data TiLOOP® Bra Pocket, a novel ready-to-use mesh pocket which acts as an internal bra and prevents the implant from dislocating or twisting.A single-centre retrospective cohort study was performed to assess short-term complication rates cosmetic outcomes in patients prepectoral Pocket. The primary endpoint during first 6 months. secondary outcome after 12 months, judged by two...
Abstract Objective: Radical vaginal trachelectomy (RVT) as a fertility-preserving surgery in patients with early-stage cervical cancer is proven to be oncologically safe. After RVT, pregnancy rates vary between 40% and 80%. Outcome of infants complicated by preterm delivery rate 30–50%. We investigated neonatal outcome after RVT. Methods: A total 154 underwent RVT March 1995 February 2008. Desire conceive, data, were prospectively recorded. Infants’ data pair-matched control group according...
To evaluate the frequency of loss mediator DNA damage checkpoint protein 1 (MDC1) expression in endometrial cancer (EC) and to determine whether MDC1 is associated with certain clinicopathological parameters.MDC1 was examined 426 samples EC. The nuclear immunoreactivity defined as: negative, weak, moderate strong.Loss (defined as negative staining) found 8.9% (38/426) ECs significantly MRE11 homolog, double-strand break repair nuclease, RAD50 nibrin complex components. In addition, showed a...
Abstract Background: The presence of circulating tumor cell (CTC) clusters is associated with progression and a bad prognosis in various cancer types1,2. In breast cancer, pre-clinical model demonstrated that Na/K-ATPase inhibitors such as digoxin could dissolve CTC reduce metastasis3. DICCT single-arm, therapeutic exploratory phase I study aimed to examine whether can disrupt metastatic patients (NCT03928210). Material methods: Metastatic whom CTCs have been detected were eligible. Patients...
Since the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, BRCA testing has evolved as a standard management in epithelial ovarian cancer.
Breast-conserving therapy (BCT) has become the standard of care for vast majority patients with early breast cancer [1]. A regular approach are two independent incisions tumor and sentinel lymph node (SLN). Despite preserving oncological safety, surgery progressively less radical in favor improved cosmetic outcome minimal functional deficiency over time [2]. Oncoplastic conserving (OPS) been widely promoted to achieve improvements aesthetic [3] [4].
PARP inhibitors are used for treatment of tumors lacking function the double-strand DNA break repair proteins BRCA1 or BRCA2 and already approved several cancer types. Thus, it is clinically crucial to determine germline as well somatic BRCA1/2 mutations in those patients. The amplicon-based Oncomine Assay a test routinely diagnostics with FFPE specimens. assay validated detection mutations, however, data on its performance detecting large genomic rearrangements tissue, scarce. We...
Ziel: Die radikale vaginale Trachelektomie (RVT) als fertilitätserhaltende Therapie bei Patientinnen mit Zervixkarzinom und prospektivem Kinderwunsch ist eine onkologisch sichere Methode. in der Literatur beschriebenen Schwangerschaftsraten nach Operation liegen zwischen 40–80%. Schwangerschaften RVT sind durch Frühgeburtsrate von 30% verkompliziert. Ziel dieser prospektiven Studie es, das neonatologische outcome Kinder zu beurteilen.
<h3>Introduction/Background*</h3> Poly(ADP-ribose) polymerase inhibitors (PARPi) have been approved for several tumor entities including epithelial ovarian cancer (EOC). The purpose of the study is to analyze current implementation BRCA testing and PARPi therapy EOC in Germany. <h3>Methodology</h3> questionnaire contained 40 questions covering real life data genetic use PARPi. It was divided into three main parts: 1. basic demographics respondents, 2. indication, counseling selection...
Abstract Aim: To evaluate the perioperative outcome and cosmetic of prepectoral implant-based breast reconstruction using TiLOOP® Bra Pocket.Background: Besides acellular dermal matrix (ADM), synthetic meshes have revealed good surgical aesthetic outcomes. We present our data Pocket, a ready-to-use mesh pocket which is made out nonresorbable, titanized, lightweight polypropylene with monofilament structure designed to ensure optimal fixation implant following mastectomy. The idea behind fix...