A5029436679- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Liver physiology and pathology
- Frailty in Older Adults
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
- Tannin, Tannase and Anticancer Activities
- Wnt/β-catenin signaling in development and cancer
- CAR-T cell therapy research
- RNA and protein synthesis mechanisms
- Cancer Immunotherapy and Biomarkers
- Pancreatic function and diabetes
- Single-cell and spatial transcriptomics
- Global Cancer Incidence and Screening
- Motor Control and Adaptation
- Genetic factors in colorectal cancer
- Traumatic Brain Injury Research
- Bone fractures and treatments
- Balance, Gait, and Falls Prevention
- Chronic Lymphocytic Leukemia Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Royal Marsden Hospital
2004-2025
École Polytechnique Fédérale de Lausanne
2025
University Hospital of Zurich
2018-2024
University of Zurich
2020-2024
Royal Marsden NHS Foundation Trust
2016-2024
ETH Zurich
2022-2024
Honeywell (United States)
2024
Mercy Fitzgerald Hospital
2024
University of Southern California
2013-2022
Curtin University
2021
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
The developmental potential of human embryonic stem cells (hESCs) holds great promise to provide a source hepatocytes for use in drug discovery, toxicology, hepatitis research, and extracorporeal bioartificial liver support. There are, however, limitations induce fully functional on conventional two-dimensional (2D) static culture. It had been shown that dynamic three-dimensional (3D) perfusion culture is superior maturation fetal prolong hepatic functions primary adult hepatocytes. We...
Cancer initiation and progression have been attributed to newly discovered subpopulations of self-renewing, highly tumorigenic, drug-resistant tumor cells termed cancer stem cells. Recently, we others reported a new phenotypic plasticity wherein cell populations could arise not only from pre-existing stem-like but also lacking these properties. In the current study, hypothesized that this newfound may be mediated by PI3K/Akt Wnt/β-catenin signaling, pathways previously implicated in...
Background: Triple negative breast cancers (TNBCs) are an aggressive BC subtype, characterized by high rates of drug resistance and a proportion cancer stem cells (CSC). CSCs thought to be responsible for tumor initiation resistance. cAMP-response element-binding (CREB) binding protein (CREBBP or CBP) has been implicated in CSC biology may provide novel therapeutic target TNBC. Methods: RNA Seq pre- post treatment with the CBP-binding small molecule ICG-001 was used characterize CBP-driven...
Abstract Background Triple negative breast cancer (TNBC) is an aggressive subtype with basal features, lacking the expression of receptors targeted successfully in other subtypes. Treatment response to adjuvant and neoadjuvant chemotherapy often short-lived metastatic spread occurs at higher rates than subtypes within first five years after diagnosis. TNBCs exhibit stem cell features are enriched for (CSC) populations. E1A Binding Protein P300 (EP300) a large protein multiple cellular...
Metastatic breast cancer (MBC) and the circulating tumor cells (CTCs) leading to macrometastases are inherently different than primary cancer. We evaluated whether whole transcriptome RNA-Seq of CTCs isolated via an epitope-independent approach may serve as a surrogate for biopsies macrometastases.We performed on fresh metastatic biopsies, CTCs, peripheral blood (PB) from 19 newly diagnosed MBC patients. were harvested using ANGLE Parsortix microfluidics system isolate based size...
// Tania B. Porras 1, 3 , Pushpinder Kaur Alexander Ring Naomi Schechter 2, and Julie E. Lang 1 Department of Surgery, Keck School Medicine, University Southern California, Los Angeles, CA, United States 2 Radiation Oncology, Medical Center, California Norris Comprehensive Cancer Correspondence to: Lang, email: Julie.Lang@med.usc.edu Keywords: circulating tumor cells (CTCs); NanoString PAM50; gene expression; target pre-amplification; PCR Received: June 20, 2017 Accepted: December 26,...
Previous studies have noted the incidence of radiation-induced sarcomas (RIS) but not investigated relative risk (RR) developing RIS based on primary tumor organ disease site. By examining data from Surveillance, Epidemiology, and End Results (SEER) database, we hypothesized that breast cancer would a higher compared to seventeen other sites. This was retrospective cohort study examined patients SEER registries between 1973 2013. We included aged 18 years or older who were diagnosed with...
Abstract Background Mycoplasma genitalium (Mg) is an emerging sexually transmitted pathogen among men who have sex with (MSM). Resistance to recommended antimicrobial agents are of public health concern. Few data exist on Mg infections in MSM diagnosed human immunodeficiency virus (HIV) during primary HIV infection. Methods Participants the Zurich Primary Study (ClinicalTrials.gov Identifier NCT 00537966) were systematically offered screening for (STIs) between April 2019 and September 2020....
Bio-artificial liver support systems have been utilized as bridging devices to acute and chronic injury. However, prolonged function of adult hepatocytes has not achieved due compromised proliferation long-term survival cells in vitro. As an alternative cell source, we investigated the potential human fetal (hFH) a four-compartment hollow fiber-based three-dimensional (3D) perfusion culture system. hFH were isolated from 17- 19-gestational-week livers cultured 3D bioreactors for 14 days....
// Alexander Ring 1, 2 , Neal Mineyev 3 Weizhu Zhu Emily Park 4 Chip Lomas 5 Vasu Punj 2, 6 Min Yu 7 Dany Barrak Victoria Forte Tania Porras Debu Tripathy 8 Julie E. Lang 1 Department of Surgery, Keck School Medicine, University Southern California, Los Angeles, CA 90033, USA Norris Comprehensive Cancer Center, Lenox Hospital New York, NY 10065, Advanced Cell Diagnostics, Research and Development, Hayward, 94545, BD Biosciences, San Jose, 95131, Division Hematology, Eli Edythe Broad Center...
Abstract Whole exome sequencing (WES), targeted gene panel and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that critical to cancer care. Here, we compared The Cancer Genome Atlas (TCGA) Genomics Evidence Neoplasia Information Exchange (GENIE) breast genomic datasets (array next generation (NGS) data) in detecting clinically relevant genes. We performed an silico analysis determine concordance frequencies mutations copy...
Myelofibrosis is a hematopoietic stem cell disorder belonging to the myeloproliferative neoplasms. patients frequently carry driver mutations in either JAK2 or Calreticulin (CALR) and have limited therapeutic options. Here, we integrate ex vivo drug response proteotype analyses across myelofibrosis patient cohorts discover targetable vulnerabilities associated strategies. Drug sensitivities of mutated progenitor cells were measured blood using high-content imaging single-cell deep...
Recent evidence suggests that progenitor cells in adult tissues and embryonic stem share a high resistance to hypoxia ischemic stress. To study the of liver progenitors, we characterized remaining viable human tissue after cold treatment for 24-168 h, applied before cell isolation. In vitro cultures isolated showed rapid decline number different types with increasing ischemia length. After all periods, progenitor-like could be observed. The comparably small exhibited low cytoplasm-to-nucleus...
Abstract A simple, fast, reproducible (2.5% RSD at 3.0 μg/L), and sensitive method is described for quantifying As(III) (0.3 μg/L detection limit, 0.5–440 dynamic range). Anodic stripping voltammetry (ASV) performed after accumulating arsenic a mercury film electrode −0.350 V vs. Ag/AgCl (saturated KCl) 20 s in 0.2 M HCl containing 8 μM ammonium 2‐amino‐1‐cyclopentene‐1‐dithiocarboxylate (AACD), without oxygen removal. This the first report of using AACD ASV electrochemical quantification...