A5055122484- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Marine Sponges and Natural Products
- Caveolin-1 and cellular processes
- Fungal Biology and Applications
- Botany, Ecology, and Taxonomy Studies
- Nanoparticles: synthesis and applications
- Tissue Engineering and Regenerative Medicine
- Rangeland and Wildlife Management
- Bone Tissue Engineering Materials
- Medicinal Plants and Neuroprotection
- Electrospun Nanofibers in Biomedical Applications
- Boron Compounds in Chemistry
- Ecology and Conservation Studies
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
Memorial Sloan Kettering Cancer Center
2021-2025
École Polytechnique Fédérale de Lausanne
2025
ETH Zurich
2023-2024
The Geneva Association
2024
National Institute of Technology Warangal
2017-2019
Warsaw University of Life Sciences
2017
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
As cancers progress, they become increasingly aggressive—metastatic tumours are less responsive to first-line therapies than primary tumours, acquire resistance successive and eventually cause death1,2. Mutations largely conserved between metastatic from the same patients, suggesting that non-genetic phenotypic plasticity has a major role in cancer progression therapy resistance3–5. However, we lack an understanding of cell states mechanisms by which transition. Here, cohort biospecimen...
Metastasis is the principal cause of cancer death, yet we lack an understanding metastatic cell states, their relationship to primary tumor and mechanisms by which they transition. In a cohort biospecimen trios from same-patient normal colon, colorectal cancer, show that while tumors largely adopt LGR5 + intestinal stem-like metastases display progressive plasticity. Loss states accompanied reprogramming into highly conserved fetal progenitor state, followed non-canonical differentiation...
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). impact of the hotspot mutation SF3B1K700E on PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1K700E alone insufficient to induce malignant transformation murine pancreas, but it increases aggressiveness if co-occurs with KRAS and p53. We further show already plays a role during early stages tumor progression reduces expression TGF-β1-responsive...
Abstract Escherichia coli (E. coli) strains carrying the polyketide synthase (pks) island produce genotoxin colibactin associated with pathogenesis of colorectal cancer (CRC). Colibactin binds directly to DNA, causing alkylating damage leading double stranded DNA breaks. mutagenesis results in mutations hexameric A-T rich motifs that can be identified by whole genome sequencing (WGS) as mutation signatures SBS28 and SBS88 (SBS-pks). Since WGS is not routinely used clinically, we developed an...
Dermatomycoses is a serious subcutaneous complication of humans and other vertebrates caused by an important group keratinophylic fungi namely Microsporum gypseum Trichophyton rubrum. The aim the present study was to investigate efficacy Cymbopogon khasans (CKEO), Cyperus scariosus essential oil (CSEO) their combination (1:1) against induced dermatophytes. CKEO, CSEO completely inhibited growth rubrum at 0.1, 0.25 0.1 µL/mL, respectively. inhibition ergosterol suggests plasma membrane as...
Abstract PURPOSE: Alterations in the gut microbiome contribute to colorectal cancer (CRC) pathogenesis. The genotoxin colibactin, produced by pks+ E. coli, directly binds DNA, leaving genetic scars at A-T rich motifs that can be identified whole genome/exome sequencing (WGS/WES) as hexanucleotide mutation signatures SBS28 and SBS41. Here, we investigated whether MSK-IMPACT, a clinical targeted exon capture assay with lower genomic coverage (341-468 associated exons), could used identify...