A5022424960- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Reconstructive Facial Surgery Techniques
- Facial Rejuvenation and Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Autoimmune and Inflammatory Disorders
- BRCA gene mutations in cancer
- Body Contouring and Surgery
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- HER2/EGFR in Cancer Research
University Hospital of Zurich
2020-2025
University of Zurich
2023-2025
Breast Center
2024
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
PURPOSE The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline BRCA1/2, high-risk human epidermal growth factor receptor 2–negative early breast cancer after completing (neo)adjuvant chemotherapy ([N]ACT), surgery, and radiotherapy. patient-reported outcome primary hypothesis was that OL-treated may experience greater fatigue during treatment. METHODS Data were collected before random assignment, at 6, 12, 18, 24...
The impact of special histological types (ST) in triple-negative breast cancer (TNBC) and its association with overall outcome has gained increasing relevance as survival been linked to specific TNBC subtypes. We evaluated the clinicopathological data 598 patients 613 TNBCs, including 464 TNBCs no type (NST) 149 ST (low-grade, n = 12, 8.1%; high-grade, 112, 75.2%; apocrine androgen receptor-positive [APO AR], 25, 16.8%). Patients low-grade APO AR were significantly older (P < 0.001) had a...
Prepectoral implant-based reconstruction using synthetic meshes is feasible with good outcomes. We present our data TiLOOP® Bra Pocket, a novel ready-to-use mesh pocket which acts as an internal bra and prevents the implant from dislocating or twisting.A single-centre retrospective cohort study was performed to assess short-term complication rates cosmetic outcomes in patients prepectoral Pocket. The primary endpoint during first 6 months. secondary outcome after 12 months, judged by two...
Abstract Augmentation mammoplasty using hydrogel fillers such as polyacrylamide gel (PAAG) or Aquafilling® has been performed commonly in some countries an alternative to breast augmentation with saline silicone implants. However, the safety of this procedure remains controversial, and many complications associated use large-volume injection have reported recent years. We present case a 33-year-old woman history bilateral who presented enlarged left while breastfeeding. Based on clinical...
Abstract Breast cancer progression to visceral organs such as lung and liver is regarded a dreadful event, unequivocally associated with poor prognosis. Yet, these vital sites are characterized by highly diverse cellular microenvironments physiological functions, suggesting that they may influence cells behavior in divergent ways. Unexpectedly, we find while the microenvironment fosters metastasis-boosting properties of its metastatic seeds favors secondary spread, lungs impose drastic...
Abstract Aim: To evaluate the perioperative outcome and cosmetic of prepectoral implant-based breast reconstruction using TiLOOP® Bra Pocket.Background: Besides acellular dermal matrix (ADM), synthetic meshes have revealed good surgical aesthetic outcomes. We present our data Pocket, a ready-to-use mesh pocket which is made out nonresorbable, titanized, lightweight polypropylene with monofilament structure designed to ensure optimal fixation implant following mastectomy. The idea behind fix...