A5029294249- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Microbial infections and disease research
- Blood groups and transfusion
- Mycobacterium research and diagnosis
- AI in cancer detection
- Medical Imaging Techniques and Applications
- Maternal and Perinatal Health Interventions
- Reproductive Health and Contraception
- Reconstructive Surgery and Microvascular Techniques
- Cancer Cells and Metastasis
- Cancer and Skin Lesions
- Reproductive tract infections research
- Global Maternal and Child Health
- Reconstructive Facial Surgery Techniques
- Photoacoustic and Ultrasonic Imaging
- Tissue Engineering and Regenerative Medicine
- Estrogen and related hormone effects
- Assisted Reproductive Technology and Twin Pregnancy
- Advanced Radiotherapy Techniques
- Ultrasound Imaging and Elastography
- Nail Diseases and Treatments
- Lymphatic System and Diseases
- Advanced X-ray and CT Imaging
University Hospital of Zurich
2019-2025
Kantonsspital Winterthur
2025
University of Zurich
2025
Royal Marsden Hospital
2023
Breast Center
2020-2022
Importance Data on oncological outcomes after omission of axillary lymph node dissection (ALND) in patients with breast cancer that downstages from positive to negative neoadjuvant chemotherapy are sparse. Additionally, the best surgical staging technique this scenario is unknown. Objective To investigate sentinel biopsy (SLNB) dual-tracer mapping or targeted (TAD), which combines SLNB localization and retrieval clipped node. Design, Setting, Participants In multicenter retrospective cohort...
Abstract The presence of circulating tumor cell (CTC) clusters is associated with disease progression and reduced survival in a variety cancer types. In breast cancer, preclinical studies showed that inhibitors the Na + /K ATPase suppress CTC block metastasis. Here we conducted prospective, open-label, proof-of-concept study women metastatic where primary objective was to determine whether treatment inhibitor digoxin could reduce mean cluster size. An analysis nine patients treated daily...
Abstract Background: Data on the oncologic safety of omission axillary lymph node dissection (ALND) in positive (N+) patients who downstage to ypN0 with neoadjuvant chemotherapy (NAC) is sparse. Additionally, there no consensus which staging procedure should be used this setting, sentinel biopsy (SLNB) alone or combination localization and retrieval clipped node, also known as targeted (TAD). Whether reduction false negative rate observed TAD translates into a significant recurrence unknown....
Abstract Background: In patients with micro- and macrometastases in the sentinel lymph node (SLN) after neoadjuvant chemotherapy (NAC), additional positive nodes are found >60% of cases axillary dissection (ALND) is currently considered standard care. The likelihood finding residual isolated tumor cells (ITCs) unknown, benefit ALND unclear. As a consequence, surgical management axilla these not standardized. We sought to evaluate how often found, determine factors associated ALND,...
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
Abstract Breast cancer is a biologically diverse disease with treatment modalities selected based on tumor stage and biology. Distinct intrinsic subtypes surrogate biomarker profiles play major role for therapeutic decisions. Response rates to systemic local treatments as well the interaction epidemiological risk factors have been validated in clinical trials translational studies. This retrospective study addresses question how neoadjuvant chemotherapy setting changed during past 15 years...
The aim of this study was to differentiate malignant and benign solid breast lesions with a novel ultrasound (US) technique, which measures speed sound (SoS) using standard US transducers intrinsic tissue reflections scattering (speckles) as internal reference.This prospective, institutional review board-approved, Health Insurance Portability Accountability Act-compliant prospective comparison performed prior written informed consent from 20 women. Ten women histological proven cancer 10...
Prepectoral implant-based reconstruction using synthetic meshes is feasible with good outcomes. We present our data TiLOOP® Bra Pocket, a novel ready-to-use mesh pocket which acts as an internal bra and prevents the implant from dislocating or twisting.A single-centre retrospective cohort study was performed to assess short-term complication rates cosmetic outcomes in patients prepectoral Pocket. The primary endpoint during first 6 months. secondary outcome after 12 months, judged by two...
The aim of this study was to investigate the feasibility, image quality, and correlation with histology dedicated spiral breast computed tomography (B-CT) equipped a photon-counting detector in patients suspicious lesions after application iodinated contrast media.The local ethics committee approved prospective study. Twelve women found mammography or B-CT underwent contrast-enhanced supplementary ultrasound. For all lesions, biopsy-proven diagnosis histological workup surgical resection...
Ultrasound (US)-guided breast biopsy is a routine diagnostic method used to correlate imaging finding histological diagnosis which still the gold standard in preoperative diagnostics. The accuracy of US-guided biopsies relies on precise radiologic-histopathologic correlation, discussed amongst an interdisciplinary team gynecologists, radiologists and pathologists. However, false-negative or non-diagnostic results occur. Hence, thorough honest discussion clarify reason for discrepancies...
Abstract Background Mycoplasma sp. are well recognized as etiological agents of respiratory and sexually transmitted disease. penetrans, a species sp., has been frequently detected in HIV-positive patients associated with the progression HIV-associated To date, there is only single case report describing M. penetrans causative agent severe tract infection HIV-negative patient. Case presentation In this report, we describe bacteremia HIV-negative, 38-year-old, female, immunocompromised, solid...
Abstract Introduction Traditionally, sentinel lymph node biopsy (SLNB) has been used to stage the axilla in early breast cancer (EBC) guide adjuvant treatment recommendations. Following advances tumor biology understanding, targeted systemic therapies and genomic testing, with increasing de-escalation of axillary surgery, its role may be less critical especially selected groups women. Aims Evaluate clinical utility SLNB recommendations for women ≥ 70 years EBC. Methods Retrospective cohort...
Simplified first-trimester abortion protocols are well established. However, data on the use of medical or surgical across Switzerland is lacking. We report protocol characteristics in care for two different facility types, hospital vs private practices (office-based) Switzerland. Furthermore, we investigate an association between and likelihood following through with at same facility. also outcomes office-based cohort where doctors simplified protocols. This study consists parts. (i)...
Breast-conserving therapy (BCT) has become the standard of care for vast majority patients with early breast cancer [1]. A regular approach are two independent incisions tumor and sentinel lymph node (SLN). Despite preserving oncological safety, surgery progressively less radical in favor improved cosmetic outcome minimal functional deficiency over time [2]. Oncoplastic conserving (OPS) been widely promoted to achieve improvements aesthetic [3] [4].
e12512 Background: Sentinel lymph node biopsy (SLNB) has traditionally been used to stage the axilla in early breast cancer (EBC) guide adjuvant treatment recommendations. Following advances genomic testing and tumor biology understanding, its role may be less critical especially selected groups of women. The aim was evaluate clinical utility SLNB recommendations for women ≥ 70 years with EBC a tertiary unit United Kingdom. Methods: Retrospective cohort study cT1-2N0 undergoing primary...