A5041673964- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Medical Imaging Techniques and Applications
- HER2/EGFR in Cancer Research
- Global Cancer Incidence and Screening
- Infrared Thermography in Medicine
- Optical Imaging and Spectroscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Reconstructive Surgery and Microvascular Techniques
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Advanced Radiotherapy Techniques
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- MRI in cancer diagnosis
- Photoacoustic and Ultrasonic Imaging
- Cancer Diagnosis and Treatment
- AI in cancer detection
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Clinical practice guidelines implementation
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
The Netherlands Cancer Institute
2016-2025
Amsterdam University Medical Centers
2021-2025
University of Amsterdam
2021-2025
University Medical Center
2021-2024
Oncode Institute
2011-2023
Cancer Institute (WIA)
2023
Dutch Cancer Society
2023
Erasmus MC
2023
Wikimedia Nederland
2023
Maastricht University Medical Centre
2023
In Brief Objective: The MARI procedure [marking the axillary lymph node with radioactive iodine (125I) seeds] is a new minimal invasive method to assess pathological response of nodal metastases after neoadjuvant systemic treatment (NST) in patients breast cancer. This allows axilla-conserving surgery responding well NST. Methods: Prior NST, proven tumor-positive nodes were marked 125I seed. so-called MARI-node. After was selectively removed using γ-detection probe. A complementary...
Purpose To evaluate the relevance of breast cancer subtypes for magnetic resonance imaging (MRI) markers monitoring therapy response during neoadjuvant chemotherapy (NAC). Patients and Methods MRI examinations were performed in 188 women before NAC. interpretation included lesion morphology at baseline, changes morphology, size, contrast uptake kinetics (initial late enhancement). By using immunohistochemistry, tumors divided into three subtypes: triple negative, human epidermal growth...
Abstract Background The onset of the COVID-19 pandemic forced Dutch national screening program to a halt and increased burden on health care services, necessitating introduction specific breast cancer treatment recommendations from week 12 2020. We aimed investigate impact diagnosis, stage initial cancer. Methods Women included in Netherlands Cancer Registry diagnosed during four periods weeks 2–17 2020 were compared with reference data 2018/2019 (averaged). Weekly incidence was calculated...
Abstract Introduction There is much literature about the role of 2-[ 18 F]FDG PET/CT in patients with breast cancer (BC). However, there exists no international guideline involvement nuclear medicine societies this subject. Purpose To provide an organized, international, state-of-the-art, and multidisciplinary guideline, led by experts two (EANM SNMMI) representation important field BC (ACR, ESSO, ESTRO, EUSOBI/ESR, EUSOMA). Methods Literature review expert discussion were performed aim...
Breast cancer is increasingly considered a heterogeneous disease. The aim of this study was to assess the differences between histological and receptor-based subtypes in breast-conserving surgery pathological complete response (pCR) after neoadjuvant chemotherapy. A consecutive series 254 patients with operable breast treated chemotherapy analyzed. Tumors were classified according their receptor status estrogen (ER)-positive tumors (HER2-negative), triple-negative tumors, HER2-positive...
Abstract Background The added value of surgery in breast cancer patients with pathological complete response (pCR) after neoadjuvant systemic therapy (NST) is uncertain. accuracy imaging identifying pCR for omission surgery, however, insufficient. We investigated the ultrasound-guided biopsies (ypT0) NST radiological partial (rPR) or (rCR) on MRI. Methods performed a multicenter, prospective single-arm study three Dutch hospitals. Patients T1–4(N0 N +) MRI rPR and enhancement ≤ 2.0 cm rCR...
In clinically node-positive (cN+) breast cancer patients, evidence supporting response-guided treatment after neoadjuvant systemic therapy (NST) instead of axillary lymph node dissection (ALND) is increasing, but follow-up results are lacking. We assessed three-year recurrence-free interval (aRFI) in cN+ patients with response-adjusted according to the 'Marking Axillary nodes Radioactive Iodine seeds' (MARI)-protocol.We retrospectively all stage II-III cytologically proven who underwent...
Abstract Background An important benefit of neoadjuvant chemotherapy is the increased potential for breast-conserving surgery. At present response axillary lymph node metastases to not easily assessed, rendering axilla-conserving treatment difficult. The aim was assess a new surgical method evaluating chemotherapy. Methods Before chemotherapy, proven tumour-positive nodes were localized using ultrasound-guided insertion iodine-125-labelled (I-125) seeds. After marked removed selectively with...
Preoperative localization is important to optimize the surgical treatment of breast lesions, especially in nonpalpable lesions. Radioactive seed (RSL) using iodine-125 a relatively new approach. To provide accurate guidance surgery, it that seeds do not migrate after placement. The aim this study was assess short-term and long-term migration RSL In 45 patients, 48 procedures were performed under ultrasound or stereotactic guidance. first 12 lesion localized with two markers: an reference...
Response monitoring with MRI during neoadjuvant chemotherapy (NAC) in breast cancer is promising, but knowledge of subtype essential. The aim the present study was to evaluate relevance subtypes for therapy response NAC 18F-FDG PET/CT.Evaluation included 98 women stages II and III cancer. PET/CTs were performed before after six or eight weeks NAC. FDG uptake quantified using maximum standardized values (SUVmax). Tumors divided into three subtypes: HER2-positive, ER-positive/HER2-negative,...
In 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation-wide audit to address quality of breast cancer care and guideline adherence in Netherlands. The development NBCA results 4 years auditing are described.Clinical pathological characteristics patients diagnosed with invasive or situ carcinoma (DCIS) information regarding diagnosis treatment collected all hospitals (n = 92) Thirty-two indicators measuring structure, processes outcomes were evaluated over time compared...
To evaluate patterns of care in axillary surgery for Dutch clinical T1-4N0M0 (cT1-4N0M0) breast cancer patients and to assess the effect American College Surgeons Oncology Group (ACOSOG)-Z0011 After Mapping Axilla: Radiotherapy Or Surgery (AMAROS) trial on cT1-2N0M0 sentinel node positive patients.Since publication ACOSOG-Z0011 AMAROS trial, omitting a completion lymph dissection (cALND) is proposed selected patients.Data were obtained from nationwide Nationaal Borstkanker Overleg Nederland...
The aim of this study was to assess the accuracy (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT visualize lymph node metastases before start neoadjuvant chemotherapy and determine how often visualization is sufficiently prominent allow monitoring axillary response.Thirty-eight patients with invasive breast cancer >3 cm and/or metastasis underwent FDG PET/CT chemotherapy. results were compared those from ultrasonography fine-needle aspiration (FNA) cytology or sentinel...