A5074277016- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Optical Imaging and Spectroscopy Techniques
- Global Cancer Incidence and Screening
- Infrared Thermography in Medicine
- Breast Implant and Reconstruction
- Medical Imaging Techniques and Applications
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Photoacoustic and Ultrasonic Imaging
- Patient-Provider Communication in Healthcare
- MRI in cancer diagnosis
- Digital Radiography and Breast Imaging
- Palliative Care and End-of-Life Issues
- Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Reconstructive Surgery and Microvascular Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Photodynamic Therapy Research Studies
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
The Netherlands Cancer Institute
2016-2025
Oncode Institute
2017-2024
Amsterdam University Medical Centers
2023
Dutch Cancer Society
2022
Radboud University Medical Center
2018
Radboud University Nijmegen
2018
European Organisation for Research and Treatment of Cancer
2018
University Medical Center Utrecht
2018
Dutch Expert Centre for Screening
2018
Amsterdam UMC Location University of Amsterdam
2018
The European Organisation for Research and Treatment of Cancer 10981-22023 AMAROS trial evaluated axillary lymph node dissection (ALND) versus radiotherapy (ART) in patients with cT1-2, node-negative breast cancer a positive sentinel (SN) biopsy. At 5 years, both modalities showed excellent comparable control, significantly less morbidity after ART. We now report the preplanned 10-year analysis recurrence rate (ARR), overall survival (OS), disease-free (DFS), an updated 5-year quality...
Abstract Background The added value of surgery in breast cancer patients with pathological complete response (pCR) after neoadjuvant systemic therapy (NST) is uncertain. accuracy imaging identifying pCR for omission surgery, however, insufficient. We investigated the ultrasound-guided biopsies (ypT0) NST radiological partial (rPR) or (rCR) on MRI. Methods performed a multicenter, prospective single-arm study three Dutch hospitals. Patients T1–4(N0 N +) MRI rPR and enhancement ≤ 2.0 cm rCR...
In clinically node-positive (cN+) breast cancer patients, evidence supporting response-guided treatment after neoadjuvant systemic therapy (NST) instead of axillary lymph node dissection (ALND) is increasing, but follow-up results are lacking. We assessed three-year recurrence-free interval (aRFI) in cN+ patients with response-adjusted according to the 'Marking Axillary nodes Radioactive Iodine seeds' (MARI)-protocol.We retrospectively all stage II-III cytologically proven who underwent...
Abstract Purpose: Complete tumor removal during cancer surgery remains challenging due to the lack of accurate techniques for intraoperative margin assessment. This study evaluates use hyperspectral imaging assessment by reporting its in fresh human breast specimens. Experimental Design: Hyperspectral data were first acquired on tissue slices from 18 patients after gross sectioning resected specimen. dataset, which contained over 22,000 spectra, was well correlated with histopathology and...
Background Ductal carcinoma in situ (DCIS) can progress to invasive breast cancer (IBC), but most DCIS lesions remain indolent. However, guidelines recommend surgery, often supplemented by radiotherapy. This implies overtreatment of indolent DCIS. The non-randomized, patient preference LORD-trial tests whether active surveillance (AS) for low-risk is safe, giving women with a choice between AS and conventional treatment (CT). Here we aim describe how participants are distributed among both...
Phyllodes tumors of the breast are rare fibroepithelial lesions that classified as benign, borderline or malignant. There is little consensus on best practice for work-up, management, and follow-up patients with phyllodes breast, evidence-based guidelines lacking.We conducted a cross-sectional survey surgeons oncologists aim to describe current clinical in management tumors. The was constructed REDCap distributed between July 2021 February 2022 through international collaborators sixteen...
Immune checkpoint inhibition (ICI) with chemotherapy is now the standard of care for stage II-III triple-negative breast cancer; however, it largely unknown which patients ICI without could be an option and what benefit combination be. The adaptive BELLINI trial explored whether short induces immune activation (primary end point, twofold increase in CD8
Breast cancer surgeons struggle with differentiating healthy tissue from at the resection margin during surgery. We report on feasibility of using diffuse reflectance spectroscopy (DRS) for real-time in vivo characterization.Evaluating technology requires a setting which measurements, imaging and pathology have best possible correlation. For this purpose an optical biopsy needle was used that had integrated fibers tip needle. This approach enabled correlation between measurement volume...
Highlights•Accurate localisation is essential for breast conserving surgery of non-palpable tumours.•A novel magnetic technology (MaMaLoc) introduced.•Fifteen cancer patients are treated with the technology.•The found feasible and safe, negligible marker migration.AbstractObjectivesAccurate tumour breast-conserving tumours. Current technologies associated disadvantages such as logistical challenges migration issues (wire guided localisation) or legislative complexities high administrative...
Trials have demonstrated the safety of omitting completion axillary lymph node dissection in patients with cT1-2 N0 breast cancer operated breast-conserving surgery who limited metastatic burden sentinel node. The aim this registry study was to provide insight into oncological treatment mastectomy limited-volume metastasis.
Axillary lymph node staging techniques after primary systemic therapy (PST) show low false negative rates, stimulating the omission of axillary dissection (ALND). Breast cancer patients with extensive nodal disease are underreported in studies on response-guided treatment. In this study, we present oncologic outcome breast ≥4 involved nodes treated according to MARI-protocol. This prospective single arm registration study included defined as FDG-PET/CT pre-PST between July 2014 and December...
Margin assessment in breast-conserving surgery (BSC) remains a critical challenge, with 20-25% of cases resulting inadequate tumor resection, increasing the risk local recurrence and need for additional treatment. In this study, we evaluate diagnostic performance hyperspectral imaging (HSI) as non-invasive technique assessing resection margins ex vivo lumpectomy specimens. A dataset over 200 specimens was collected using two cameras, classification algorithm developed to distinguish between...
There is an unmet clinical need for accurate, rapid and reliable tool margin assessment during breast-conserving surgeries. Ultrasound offers the potential a rapid, reproducible, non-invasive method to assess margins. However, it challenged by certain drawbacks, including low signal-to-noise ratio, artifacts, experience with acquirement interpretation of images. A possible solution might be computer-aided ultrasound evaluation. In this study, we have developed new ensemble approaches...
PURPOSE A number of studies are currently investigating de-escalation radiation therapy in patients with a low risk in-breast relapses on the basis clinicopathologic factors and molecular tests. We evaluated whether 70-gene score is associated locoregional recurrence (LRR) estimated 8-year cumulative incidences for LRR early-stage breast cancer treated conservation. METHODS In this exploratory substudy European Organisation Research Treatment Cancer 10041/BIG 03-04 MINDACT trial, we women...
Aim The aim of our study is to analyze patterns in treatment and outcome a population-based series patients with borderline malignant phyllodes tumors (PT). Material methods Data on all or PT (1989-2020) were extracted from the Netherlands Cancer Registry Dutch nationwide pathology databank (Palga) retrospectively analyzed. Results We included 921 (borderline n=452 n=469). Borderline more often had breast-conserving surgery (BCS) as final (81 vs. 46%). BCS rates for increased over time (OR...
SignificanceDuring breast-conserving surgeries, it is essential to evaluate the resection margins (edges of breast specimen) determine whether tumor has been removed completely. In current surgical practice, there are no methods available aid in accurate real-time margin evaluation.AimIn this study, we investigated diagnostic accuracy diffuse reflectance spectroscopy (DRS) combined with tissue classification models discriminating tumorous from healthy up 2 mm depth on actual vivo...