A5066599188- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Vascular Tumors and Angiosarcomas
- Breast Lesions and Carcinomas
- Cardiac tumors and thrombi
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Platelet Disorders and Treatments
- Ion channel regulation and function
- Neuroendocrine Tumor Research Advances
- Autophagy in Disease and Therapy
- Chronic Myeloid Leukemia Treatments
- Dialysis and Renal Disease Management
- Biochemical and Molecular Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Heart Failure Treatment and Management
- Soft tissue tumor case studies
- HIV/AIDS drug development and treatment
Karolinska University Hospital
2003-2025
Karolinska Institutet
2014-2025
Sprint Bioscience (Sweden)
2018
Phyllodes tumors of the breast are rare fibroepithelial lesions that classified as benign, borderline or malignant. There is little consensus on best practice for work-up, management, and follow-up patients with phyllodes breast, evidence-based guidelines lacking.We conducted a cross-sectional survey surgeons oncologists aim to describe current clinical in management tumors. The was constructed REDCap distributed between July 2021 February 2022 through international collaborators sixteen...
Angiosarcoma, an aggressive sarcoma subtype originating from lymphatic or vascular endothelial cells, is rare, constituting less than 2% of all soft tissue sarcomas. Predominantly affecting adult and elderly patients, it manifests diversely across various anatomical locations, with cutaneous lesions being the most common, particularly in head neck region. Noteworthy for its infiltrative nature, angiosarcoma demonstrates high rates local recurrence metastasis, leading to poor overall...
Abstract Purpose Sarcomas of the breast account for about 1% all malignancies. The aim this national survey was to explore etiologic and prognostic factors. Methods Utilizing Swedish registers, patients registered with mesenchymal tumors in during period 1993–2013 ( n = 344) were identified compared up ten age gender matched controls. Cancer history retrieved cases Conditional Poisson regression models used calculation odds ratios. Results Previous cancer overrepresented among angiosarcoma....
Abstract Surgery is the cornerstone of gastrointestinal stromal tumor (GIST) treatment, and adjuvant therapy with imatinib has improved survival for high‐risk tumors. The use preoperatively been increasing, but efficacy impact on patient outcomes have not formally investigated. This a retrospective study from single‐center cohort patients diagnosed GIST treated neoadjuvant at Karolinska University Hospital in Stockholm, Sweden over 20‐year period. Eighty‐four were identified included. Tumors...
Breast angiosarcoma is a rare disease mostly observed in breast cancer (BC) patients who have previously received radiotherapy (RT). Little known about aetiology, management, and outcome. The study aim was to estimate risk characterize Swedish population-based cohort.The Cancer Registry searched for between 1992 2018 three healthcare regions (population 5.5 million). Information on previous BC, RT, outcome were retrieved from medical records.Overall, 49 angiosarcomas located the breast,...
Abstract Background Surgical resection is still the main treatment for gastrointestinal stromal tumor (GIST), and R0 excision, regardless of surgical margins, considered sufficient. Methods A cohort 79 consecutive GIST cases treated at Karolinska University Hospital, who were without metastasis diagnosis had not received any pre‐or postoperative with tyrosine kinase inhibitors, was included. margins evaluated time surgery classified as wide, marginal or intralesional. Time to...
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm in gastrointestinal tract. In GISTs, underlying mechanism a gain-of-function mutation KIT or PDGFRA gene. Imatinib tyrosine kinase inhibitor that specifically blocks intracellular ATP-binding sites of these receptors. A correlation exists between plasma levels imatinib and progression-free survival, but it not known whether concentration correlates with drug concentration. We determined two GIST cell lines:...
Gastrointestinal stromal tumour (GIST) is the most common intra-abdominal sarcoma. Risk classification systems, commonly modified National Institutes of Health consensus criteria, identify properties relating to patient outcomes. However, owing limited long-term evidence, guidelines recommend up 10-year follow-up for all risk groups except very low-risk GIST.This retrospective multicentre study included patients who had complete resection primary, non-metastatic GIST from three Scandinavian...
Abstract Introduction Phyllodes tumours (PT) are fibroepithelial breast divided into benign, borderline, and malignant PT. Method We here present the first Swedish practice guidelines for clinical management of PT, from an interdisciplinary working group in Stockholm region. Result PT should be suspected patients over ≥ 30 years age presenting with a fast-growing lump and/or 5 cm size. There diagnostic challenges specific to which difficult separate fibroadenoma other lesions on radiology....