A5046086653- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Brain Metastases and Treatment
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
- Hippo pathway signaling and YAP/TAZ
- Cancer survivorship and care
- MRI in cancer diagnosis
- Menopause: Health Impacts and Treatments
- Clusterin in disease pathology
University of Ulsan
2022-2025
Asan Medical Center
2022-2025
Ulsan College
2022-2025
Dana-Farber Cancer Institute
2024-2025
Harvard University
2024-2025
Weatherford College
2023
Seoul St. Mary's Hospital
2016-2023
Catholic University of Korea
2017-2023
Seoul National University Hospital
2017-2022
University of Seoul
2021
Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors (ICIs) are only efficacious for subset of patients. To gain better understanding the antitumor response we examined heterogeneity CD8 + T cells tumors, metastatic lymph nodes (mLNs), and peripheral blood from patients with early cancer ( n = 131). Among tissue-resident memory (T RM ) cells, including virus- tumor-specific CD39 expression was observed exhausted subpopulation both tumors mLNs. mLNs...
Hormone replacement therapy (HRT) increases the risk of breast cancer, but association may vary according to patient factors. We investigated between HRT and cancer in a nationwide cohort with stratification factors for cancer.Using Korean National Health Insurance Service database, 4,558,376 postmenopausal women who underwent screening regular health checkups from 2009 2014 were analyzed.A total 696,084 (15.3%) reported current or previous use. Breast was newly diagnosed 26,797 (0.6%)...
Advances in chemotherapeutic and targeted agents have increased pathologic complete response (pCR) rates after neoadjuvant systemic therapy (NST). Vacuum-assisted biopsy (VAB) has been suggested to accurately evaluate pCR. This study aims confirm the non-inferiority of 5-year disease-free survival patients who omitted breast surgery when predicted a pCR based on magnetic resonance imaging (MRI) VAB NST, compared with had undergone previous studies.
The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management not standardized. We investigated rates additional positive (LNs) at node dissection (ALND) oncologic outcomes ypN0i+ treated without ALND.
In breast-conserving surgery (BCS), clear resection margins are crucial to prevent recurrence. Accurate imaging is vital for precise BCS, with MRI being the most accurate. However, has limitations in identifying exact extent of breast cancer patients who have undergone neoadjuvant chemotherapy (NACT). A 3D-Printed Breast Surgical Guide (3DP-BSG) can address this issue by effectively pinpointing NACT patients, thus enhancing surgical accuracy. This retrospective single-institution cohort...
This study analyzed the pathological complete response (pCR) rates, long-term outcomes, and biological features of human epidermal growth factor receptor 2 (HER2)-zero, HER2-low, HER2-positive breast cancer patients undergoing neoadjuvant treatment. single-center included 1,667 who underwent chemotherapy from 2008 to 2014. Patients were categorized by HER2 status, their clinicopathological characteristics, responses, recurrence-free survival (RFS) rates analyzed. with HER2-low tumors more...
Central nervous system (CNS) metastases are associated with poor prognosis in patients metastatic breast cancer (MBC). In this retrospective study, we investigated the activity of sacituzumab govitecan (SG) 33 HER2-negative MBC and CNS metastases, including active, stable/treated, leptomeningeal disease (LMD). SG demonstrated a modest objective response rate 4/30 (13%) median CNS-progression-free survival 2.9 months (95%CI:2.0-4.3) heavily pretreated population.
The purpose of this study was to compare locoregional recurrence-free survival (LRFS) and disease-free (DFS) between patients undergoing mastectomy immediate breast reconstruction (IBR) those alone. A retrospective review who underwent for resectable invasive cancer 2002 2010 at a single center conducted. These cases were matched alone in the same time period, performed by 1:2 matching. Matching control variables included age, tumor size, axillary lymph node metastasis, estrogen receptor...
Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency germline using an next-generation sequencing (NGS)-based multiple-gene panel containing 64 cancer-predisposing genes in Korean breast patients with clinical features hereditary and ovarian (HBOC).A total associated were selected for development NGS-based multi-gene panel. Targeted was performed to identify 496 HBOC who underwent surgery between...
The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the rates of screening, case identification, and referral for cancer diagnosis. We investigated diagnosis surgery status breast before after COVID-19 at a multi-institutional level.We collected data from clinical warehouse which contained medical records patients six academic institutions in South Korea. Patients were divided into two groups: February to April (period A) May July B). groups then compared against same...
Previous studies examining the relationship between time to treatment and survival outcome in breast cancer have shown inconsistent results. The aim of this study was analyze overall impact delay initiation on patient determine whether certain subgroups require more prompt treatment. This is a retrospective analysis stage I-III patients who were treated single tertiary institution 2005 2008. Kaplan-Meier Cox proportional hazards regression model used evaluate interval diagnosis various...
To decide the optimal treatment for breast cancer patients with locoregional recurrence (LRR), it is important to determine which group has highest risk of subsequent distant metastasis (DM). We aimed investigate factors associated DM in LRR. reviewed data 208 LRR as first event after primary surgery at our institution between 1997 and 2010, identify significant DM. Subsequently, Kaplan-Meier curves Cox regression method were used analyze correlation clinical survival. occurred 33.2%...
The American College of Surgeons Oncology Group Z0011 trial reported that complete dissection axillary lymph nodes (ALNs) may not be warranted in women with clinical T1-T2 tumors and one or two involved ALNs who were undergoing lumpectomy plus radiation followed by systemic therapy. present study was conducted to identify preoperative imaging predictors ≥ 3 ALNs.The training set consisted 1,917 patients node negative invasive breast cancer. Factors associated evaluated logistic regression...
Abstract In our previous study, we developed a triple-negative breast cancer (TNBC) subtype classification that correlated with the TNBC molecular subclassification. this aimed to evaluate predictor variables of on whole slide and validate model’s performance by using an external test set. We explored characteristics investigated genomic alterations, including scar signature scores. First, was classified into luminal androgen receptor (LAR) non-luminal (non-LAR) subtypes based AR Allred...
The clinical impact of 16α-
Objective The aim of our study was to evaluate the effect tumor growth rate, calculated from size measurements by US, on breast cancer patients' outcome. Patients and Methods Breast patients who received at least two serial ultrasonographies (US) in institution during preoperative period were surgically treated between 2002 2010 reviewed. Tumor rate determined specific (SGR) using time point sizes US. Results A total 957 analyzed. median duration initial second US 28 days (range, 8–140)....
Pathological complete response (pCR) of axillary lymph node (LN) is frequently achieved in patients with clinically node-positive breast cancer after neoadjuvant chemotherapy (NAC). Treatment the axilla NAC not well established and value sentinel LN biopsy following remains unclear. This study investigated predictive evaluated a model based on response.Data prospectively collected 201 who were treated underwent dissection (ALND) retrieved. A pCR was developed clinicopathologic variables. The...