A5100746109- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- MicroRNA in disease regulation
- AI in cancer detection
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- RNA Research and Splicing
- Digital Radiography and Breast Imaging
- Global Cancer Incidence and Screening
- Diverse Approaches in Healthcare and Education Studies
- Ultrasound Imaging and Elastography
- Education and Learning Interventions
- Palliative Care and End-of-Life Issues
- Educational Systems and Policies
- Cancer survivorship and care
- Breast Implant and Reconstruction
- Electrical and Bioimpedance Tomography
- Family Support in Illness
- Endodontics and Root Canal Treatments
- Tracheal and airway disorders
- Healthcare Education and Workforce Issues
- Advanced Neuroimaging Techniques and Applications
Korea University Medical Center
2022-2025
Korea University
2024-2025
Kyung Hee University
2023-2025
Seoul National University Hospital
2015-2024
Seoul National University
2010-2024
Sungkyunkwan University
2017-2024
Samsung Medical Center
2017-2024
Yonsei University
2003-2024
National University College
2015-2022
Kangwon National University
2020
Abstract Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown play key regulatory roles cell progression. For example, miR-34a induced p53 activation and mediates G1 by down-regulating multiple cycle–related transcripts. Here we show that genotoxic stress promotes the p53-dependent up-regulation of homologous miRNAs miR-192 miR-215. Like miR-34a, miR-192/215 induces arrest, suggesting miRNA families operate network....
Significance This work describes an intriguing strategy for the formation of hydrogel-laden multiform structures utilizing paper sheets and suggests a route trachea tissue engineering. It combines concepts extracted from origami, functional thin polymer coating, hydrogel layering on top scaffolds. A computer-aided design-based lock-and-key arrangement was used folding into with spatial arrangements. With encapsulating cells in paper, scaffold system able to deliver biological cues vivo. In...
Image-guided breast biopsy of a residual imaging abnormality or tumor bed after neoadjuvant chemotherapy (NACT) is increasingly used to assess cancer, facilitate risk-adaptive surgery, and potentially identify exceptional responders in whom local therapy may be de-escalated.To further the accuracy post-NACT image-guided predict cancer breast.This diagnostic study analyzed multicenter patient-level data patients with who were treated NACT underwent before surgery at Royal Marsden Hospital...
Background In patients who are expected to achieve axillary pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC), omission of lymph node (LN) dissection could prevent morbidity and complications. Purpose To develop a clinical model predict residual LN metastasis in with clinically node-positive breast cancer NAC by using MRI US. Materials Methods this retrospective study, women were treated following surgery between January 2015 September 2017 included. The randomly...
Background There is an increasing need to develop a more accurate prediction model for pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer. Purpose To nomogram based on MRI and clinical-pathologic variables predict pCR. Materials Methods In this single-center retrospective study, consecutive women with stage II–III cancer who underwent NAC followed by surgery between January 2011 December 2017 were considered inclusion. The divided into development cohort...
Purpose To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) subjects with breast cancer. Materials Methods A recently developed technique named MREPT (MR properties tomography) together novel coil combination process was used quantify the values. The overall validated phantom study. In addition, 90 were imaged (50 previously biopsy-confirmed tumor 40 normal subjects), which approved by our institutional review board (IRB)....
ABSTRACT Objectives: To evaluate changes in the volume and cross-sectional area of nasal airway before 1 year after nonsurgical miniscrew-assisted rapid maxillary expansion (MARME) young adults. Materials Methods: Fourteen patients (mean age, 22.7 years; 10 women, four men) with a transverse discrepancy who underwent cone beam computed tomography (T0), immediately (T1), (T2) were retrospectively included this study. The cavity nasopharynx anterior, middle, posterior segments measured...
Abstract A major limitation of screening breast ultrasound (US) is a substantial number false-positive biopsy. This study aimed to develop deep learning-based computer-aided diagnosis (DL-CAD)-based diagnostic model improve the differential US-detected masses and reduce diagnoses. In this multicenter retrospective study, was developed based on US images combined with information obtained from DL-CAD software for patients detected using US; data were two hospitals (development set: 299...
Background Little is known regarding findings at imaging associated with survival in patients luminal breast cancer treated neoadjuvant chemotherapy (NAC). Purpose To determine the relationship between (MRI, US, and mammography) clinical-pathologic variables predicting distant metastasis-free (DMFS) overall (OS) NAC. Materials Methods In this retrospective study, consecutive women who underwent NAC followed by surgery were identified from registries of two hospitals. Women one hospital...
Background Few studies have compared abbreviated breast MRI with full-protocol in women a personal history of cancer (PHBC), and they not adjusted for confounding variables. Purpose To compare PHBC by using propensity score matching to adjust Materials Methods In this single-center retrospective study, who underwent (January 2008-August 2017) or (September 2017-April 2019) were identified. With use score-matched cohort, screening performances between the two groups McNemar test...
Background Both temporal changes in imaging characteristics of lymphadenopathy on US scans after COVID-19 vaccination and expected duration radiologically evident remain uncertain. Purpose To longitudinally evaluate vaccine–associated axillary at various time intervals both messenger (mRNA) vector vaccine recipients. Materials Methods This prospective cohort study was conducted between March 2021 January 2022. The participants were asymptomatic women without breast cancer who had received...
Background parenchymal enhancement (BPE) is a known risk factor for breast cancer. However, studies on the association between BPE and second cancer are still lacking. Purpose To investigate whether at surveillance MRI associated with subsequent in women personal history of Materials Methods A retrospective search imaging database an academic medical center identified consecutive examinations performed January 2008 December 2017 who underwent surgery primary had no prior diagnosis was...
Advances in chemotherapeutic and targeted agents have increased pathologic complete response (pCR) rates after neoadjuvant systemic therapy (NST). Vacuum-assisted biopsy (VAB) has been suggested to accurately evaluate pCR. This study aims confirm the non-inferiority of 5-year disease-free survival patients who omitted breast surgery when predicted a pCR based on magnetic resonance imaging (MRI) VAB NST, compared with had undergone previous studies.
Obesity is a major cause of conditions such as type 2 diabetes and non-alcoholic fatty liver disease, posing threat to public health worldwide. Here, we analyzed the anti-obesity effects standardized ethanol extract Cassia mimosoides var. nomame Makino (EECM) in vitro vivo. Treatment 3T3-L1 adipocytes with EECM suppressed adipogenesis lipogenesis via AMP-activated protein kinase pathway by downregulating expression levels CCAAT/enhancer-binding protein-alpha, peroxisome...
To test the performance of an artificial intelligence-based computer-aided diagnosis (AI-CAD) designed for full-field digital mammography (FFDM) when applied to synthetic (SM). We analyzed 501 women (mean age, 57 ± 11 years) who underwent preoperative and breast cancer surgery. This cohort consisted 1002 breasts, comprising 517 with 485 without. All patients tomosynthesis (DBT) FFDM during workup. The SM is routinely reconstructed using DBT. Commercial AI-CAD (Lunit Insight MMG, version...