A5051390263- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Meningioma and schwannoma management
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Advanced Breast Cancer Therapies
- Economic and Financial Impacts of Cancer
- Management of metastatic bone disease
- Palliative Care and End-of-Life Issues
- Cancer Genomics and Diagnostics
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Radiopharmaceutical Chemistry and Applications
- Cancer Treatment and Pharmacology
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Melanoma and MAPK Pathways
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
Dana-Farber Brigham Cancer Center
2016-2025
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Dana-Farber Cancer Institute
2016-2025
Boston Children's Hospital
2015-2022
Center for Neuro-Oncology
2014-2021
Cambridge Health Alliance
2021
Cambridge Hospital
2021
Dana-Farber/Harvard Cancer Center
2016-2021
Foundation Medicine (United States)
2021
To examine the impact of marital status on stage at diagnosis, use definitive therapy, and cancer-specific mortality among each 10 leading causes cancer-related death in United States.We used Surveillance, Epidemiology End Results program to identify 1,260,898 patients diagnosed 2004 through 2008 with lung, colorectal, breast, pancreatic, prostate, liver/intrahepatic bile duct, non-Hodgkin lymphoma, head/neck, ovarian, or esophageal cancer. We multivariable logistic Cox regression analyze...
Brain metastases are associated with significant morbidity and mortality. Population-level data describing the incidence prognosis of patients brain lacking. The aim this study was to characterize at diagnosis systemic malignancy using recently released from Surveillance, Epidemiology, End Results (SEER) program.
Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published diagnosis-specific Graded Prognostic Assessment (GPA). Updates larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes this work are to present all updated indices in a single report guide treatment choice, stratify...
This study investigates the association between immunotherapy and symptomatic radiation necrosis in patients with melanoma, non–small-cell lung cancer, or renal cell carcinoma newly diagnosed brain metastases treated stereotactic therapy.
Population-based estimates of the incidence and prognosis brain metastases at diagnosis breast cancer are lacking.To characterize proportions median survivals patients with time diagnosis.Patients were identified using Surveillance, Epidemiology, End Results (SEER) database National Cancer Institute. Data stratified by subtype, age, sex, race. Multivariable logistic Cox regression performed to identify predictors presence factors associated all-cause mortality, respectively. For incidence,...
Meningiomas are the most common primary intracranial tumor in adults. Identification of SMO and AKT1 mutations meningiomas has raised possibility targeted therapies for some patients. The frequency such clinical cohorts presence other actionable important to define.We used high-resolution array-comparative genomic hybridization prospectively characterize copy-number changes 150 then characterized these samples AKT1, KLF4, NF2, PIK3CA, SMO, TRAF7.Similar prior reports, we identified a subset...
BACKGROUND To the authors' knowledge, it remains unknown whether race‐based differences in cancer outcomes have changed with time. In current study, authors assessed racial disparities cancer‐specific mortality improved over last 20 years. METHODS The Surveillance, Epidemiology, and End Results program was used to identify 2,713,474 patients diagnosed between 1988 2007 either lung, breast, prostate, or colorectal (the leading 3 causes of cancer‐related among each sex). After exclusions,...
<h3>Importance</h3> Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care patients with small cell lung cancer. Data on SRS are limited. <h3>Objective</h3> To characterize and compare first-line outcomes (without prior WBRT or prophylactic cranial irradiation) those WBRT. <h3>Design, Setting, Participants</h3> FIRE-SCLC (First-line Radiosurgery Small-Cell Lung Cancer) was a...
Meningiomas are the most common primary intracranial tumor in adults. Clinical care is currently guided by World Health Organization (WHO) grade assigned to meningiomas, a 3-tiered grading system based on histopathology features, as well extent of surgical resection. behavior, however, often fails conform WHO grade. Additional prognostic information needed optimize patient management.We evaluated whether chromosomal copy-number data improved prediction time-to-recurrence for patients with...
Brain metastasis impacts greatly on patients' quality of life and survival. The phase I NANO-RAD trial assessed the safety maximum tolerated dose systemic administration a novel gadolinium-based nanoparticle, AGuIX, in combination with whole brain radiotherapy patients multiple metastases not suitable for stereotactic radiotherapy.Patients measurable received escalating doses AGuIX nanoparticles (15, 30, 50, 75, or 100 mg/kg intravenously) day initiation WBRT (30 Gy 10 fractions) 5 cohorts 3...
BACKGROUND The prognosis for patients with atypical and malignant meningioma is guarded; whether the extent of resection associated survival‐based outcomes in this population remains poorly defined. This study investigated association between gross total (GTR) all‐cause mortality meningioma. METHODS Surveillance, Epidemiology, End Results program was used to identify 575 64 betweens ages 18 70 years who were diagnosed meningioma, respectively, 2004 2009. Multivariate Cox proportional hazards...
// Ziming Du 1 , Malak Abedalthagafi Ayal A. Aizer 2 Allison R. McHenry 3 Heather H. Sun Mark-Anthony Bray 4 Omar Viramontes 5 Revaz Machaidze 1,5 Priscilla K. Brastianos 6,7 David Reardon 6 Ian F. Dunn Gordon J. Freeman Keith L. Ligon 1,6 Anne E. Carpenter Brian M. Alexander Nathalie Y. Agar Scott Rodig Elizabeth Bradshaw and Sandro Santagata 1,8 Department of Pathology, Brigham Women's Hospital Harvard Medical School, Boston, Massachusetts, USA Radiation Oncology, Neurology, Imaging...
BACKGROUND The objective of this study was to examine the effects marital status on stage at presentation, receipt treatment, and survival in patients with head neck cancer (HNC). METHODS Surveillance, Epidemiology, End Results database used analyze 51,272 who were diagnosed HNC from 2007 2010. impact definitive HNC‐specific mortality (HNCSM) determined using multivariable logistic Fine Gray competing‐risks regression models, as appropriate. RESULTS Marriage had a protective effect against...
Multidisciplinary clinics offer a unique approach to the management of patients with cancer. Yet, limited data exist show that such affect management. The purpose this study was determine whether consultation at multidisciplinary clinic is associated selection active surveillance in low-risk prostate cancer.The comprised 701 men cancer managed three tertiary care centers Boston, MA 2009. Patients either obtained clinic, which they were seen by combination urologic, radiation, and medical...
Objectives The clinical management of meningioma is guided by tumor grade and biological behavior. Currently, the assessment follows surgical resection histopathologic review. Reliable techniques for pre-operative determination may enhance decision-making. Methods A total 175 patients (103 low-grade 72 high-grade) with contrast-enhanced T1-MRI were included. Fifteen radiomic (quantitative) 10 semantic (qualitative) features applied to quantify imaging phenotype. Area under curve (AUC) odd...
Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially high-grade meningiomas. Furthermore, recent application unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie substantial percentage These insights may serve to craft...
The Patient Protection and Affordable Care Act (ACA) will likely improve insurance coverage for most young adults, but subsets of adults in the United States face significant premium increases individual market. We examined association between status cancer-specific outcomes among adults.We used SEER program to identify 39,447 patients age 20 40 years diagnosed with a malignant neoplasm 2007 2009. stage at presentation, employment definitive therapy, all-cause mortality was assessed using...
The impact of adjuvant radiation in patients with atypical meningioma remains poorly defined. We sought to determine the therapy this population.We identified 91 World Health Organization grade II (atypical) managed at Dana-Farber/Brigham and Women's Cancer Center between 1997 2011. A propensity score model incorporating age diagnosis, gender, Karnofsky performance status, tumor location, size, reason for era treatment was constructed using logistic regression outcome receipt versus...