A5016414138- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related cognitive impairment studies
- Prostate Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Phytochemical compounds biological activities
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Insect Utilization and Effects
- Silk-based biomaterials and applications
- Cardiovascular and exercise physiology
- Effects of Radiation Exposure
- PARP inhibition in cancer therapy
- Histiocytic Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
Niigata University
2016-2024
Niigata University Medical and Dental Hospital
2016-2022
Kindai University
2004-2007
Osaka Medical and Pharmaceutical University
2007
Osaka City General Hospital
2006-2007
Hyogo Medical University
2006
Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published diagnosis-specific Graded Prognostic Assessment (GPA). Updates larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes this work are to present all updated indices in a single report guide treatment choice, stratify...
Breast cancer treatment is based on estrogen receptors (ERs), progesterone (PRs), and human epidermal growth factor receptor 2 (HER2). At the time of metastasis, status can be discordant from that at initial diagnosis. The purpose this study was to determine incidence discordance its effect survival subsequent in patients with breast brain metastases (BCBM).A retrospective database 316 who underwent craniotomy for BCBM between 2006 2017 created. Discordance considered present if ER, PR, or...
Abstract In conventional stereotactic radiosurgery (SRS), treatment of multiple brain metastases using isocenters is time‐consuming resulting in long dose delivery times for patients. A single‐isocenter technique has been developed which enables the simultaneous irradiation targets at one isocenter. This requires accurate positioning patient to ensure optimal coverage. We evaluated effect six degrees freedom (6DoF) setup errors setups on SRS distributions a technique. used simulated...
Abstract Radiation therapy used in the treatment of cancer causes skin damage, and no method care has been established thus far. Recently, it become clear that sericin derived from silkworm cocoons moisturizing antioxidant functions. In addition, green cocoon-derived sericin, which is rich flavonoids, may have enhanced However, whether this can reduce radiotherapy-induced damage unclear. present study, we aimed at establishing methods to cell caused by X-irradiation using sericin. We...
Docetaxel plus cisplatin and docetaxel irinotecan are active well-tolerated chemotherapy regimens for advanced non-small-cell lung cancer (NSCLC). A randomised phase II study compared their efficacy toxicity in 108 patients with stage IIIb/IV NSCLC, who were to receive 60 mg m(-2) 80 on day 1 (DC; n=51), or 8 (DI; n=57) every 3 weeks. Response rates 37% DC 32% DI patients. Median survival times 1- 2-year 50 weeks (95% confidence interval: 34-78 weeks), 47 25% DC, 46 37-54 40 18% DI,...
Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, markedly differs among molecular subgroups and their biomarkers are unknown. Through unbiased screening, we found Schlafen family member 11 (SLFN11), which is known to improve response DNA damaging agents various cancers, be one of the top prognostic markers medulloblastomas. Hence, explored expression functions SLFN11 medulloblastoma.SLFN11 for each subgroup...
Concurrent chemoradiotherapy (CCRT) for head and neck cancer (HNC) is a risk factor oral candidiasis (OC). As Candida spp. are highly virulent, we conducted retrospective study to determine whether OC increases the severity of dysphagia related mucositis in HNC patients.We retrospectively analyzed cases consecutive patients with carcinomas cavity, pharynx, larynx who underwent CCRT containing cisplatin (CDDP) at our hospital. The diagnosis was based on gross mucosal appearance. We performed...
Abstract Purpose We calculated the dosimetric indices and estimated tumor control probability (TCP) considering six degree‐of‐freedom (6DoF) patient setup errors in stereotactic radiosurgery (SRS) using a single‐isocenter technique. Methods used simulated spherical gross volumes (GTVs) with diameters of 1.0 cm (GTV 1), 2.0 2), 3.0 3), distance ( d ) between target center isocenter was set to 0, 5, 10 cm. created dose distribution by convolving blur component uniform distribution. The...
To minimize cognitive decline without increasing brain tumor recurrence (BTR) by reduced-dose whole-brain radiotherapy (RD-WBRT) (25 Gy, 10 fractions) + stereotactic radiosurgery (SRS) in patients with ≤ 4 metastases.Eligible metastases on contrast-enhanced MRI and Karnofsky Performance Status ≥ 70. The primary endpoint was the non-inferiority of BTR at distant sites (BTR-distant)-free survival 6 months compared to that standard dose (SD)-WBRT (30 SRS arm a randomized clinical trial...
There are no quantitative selection criteria for identifying high-grade glioma (HGG) patients who suited volumetric-modulated arc therapy (VMAT). This study aimed to develop that can be used the of optimal treatment modality in HGG. We analyzed 20 with HGG treated by 3D conformal radiotherapy (3DCRT). First, VMAT plans were created each patient retrospectively. For plan, normal tissue complication probability (NTCP) brain was calculated. then divided based on NTCPs 3DCRT brain, using...
Germinomatous germ cell tumor is highly sensitive to chemoradiotherapy; patients are expected survive for decades. Many radiation-induced malignant gliomas (RIMGs) occur >10 years after radiotherapy. Standard therapy RIMGs has not been established because of the lesion's rarity, patient's shorter survival period, and risk radiation necrosis by repeat radiation.Two patients, a 32-year-old man 50-year-old man, developed glioblastomas more than 20 monotherapy germinoma with or without mature...
Our objectives were to (1) investigate the feasibility of use Japanese version Hopkins Verbal Learning Test-Revised (HVLT-R); (2) identify clinical factors influencing HVLT-R scores patients undergoing whole-brain radiation therapy (WBRT); and (3) compare neurocognitive function (NCF) after WBRT in different dose fractionation schedules. We administered (Japanese version) before (baseline) at four eight months 45 who received either therapeutic (35Gy-in-14, n = 16; 30Gy-in-10, 18) or...
We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis.We categorized by changes NCF into groups improvement versus deterioration if at least one domain showed that exceeded cut-off while other domains remained stable. The remaining were as stable, and both significant 'both.' examined clinical meaning using values 1.0, 1.5, 2.0...
Objectives: We evaluated the radiobiological effectiveness based on yields of DNA double-strand breaks (DSBs) field induction with flattening filter (FF) and FF-free (FFF) photon beams. Methods: used particle heavy ion transport system (PHITS) a water equivalent phantom (30 × 30 cm 3 ) to calculate physical qualities dose-mean lineal energy (y D 6 MV FF FFF. The relative biological DNA-DSBs (RBE DSB was calculated for standard radiation such as 220 kVp X-rays by using estimating SSBs DSBs....
Background and purposeTo compare chemoradiotherapy (CRT) with low-dose continuous 5-fluorouracil (5FU) to CRT 5FU+cisplatin (CDDP) for esophageal squamous cell carcinoma (ESCC) in a retrospective cohort study.Methods materialsWe reviewed the cases of Stage I–IV ESCC patients who underwent definitive 2000–2014. Concomitant chemotherapy was one three regimens: (1) high-dose intermittent 5FU CDDP (standard-dose FP: SDFP), (2) (LDFP), or (3) (LD5FU). The general selection criteria were: SDFP...
This study investigated the efficacy and safety of radiotherapy as part multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data 49 HCC patients treated with were assessed retrospectively. The was by progression-free survival, disease control rate, overall survival. Safety symptoms hematological assay, changes in hepatic reserve function determined Child–Pugh score albumin–bilirubin (ALBI) score. Forty underwent curative radiotherapy, nine portal vein tumor...
We aimed to compare the outcomes of high-dose-rate brachytherapy (HDR-BT) boost and external beam radiation therapy (EBRT) alone for high-risk prostate cancer. This was a single-center, retrospective observational study. Consecutive patients who underwent initial radical treatment by HDR-BT or EBRT from June 2009 May 2016 at Niigata University Medical Dental Hospital, Japan were included. A total 96 boost, 61 alone. The prescription dose set 18 Gy twice day with 39 Gy/13 fractions. mostly 70...
1079 Background: Brain metastases (BM) are a common and fatal complication of breast cancer but survival varies widely based on various prognostic factors (PF). Hence, patient counseling therapeutic decisions should be individualized. We previously published index (Breast GPA) cohort A (1985-2007, n = 642), updated it with tumor subtype in B (1993-2010, 400) now updating larger contemporary (C). Methods: multi-institutional (19) multi-national (3) retrospective database 2473 patients BM...