A5077969502- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Facial Nerve Paralysis Treatment and Research
- Neurosurgical Procedures and Complications
- Ultrasound and Hyperthermia Applications
- Cerebrovascular and Carotid Artery Diseases
- Lymphoma Diagnosis and Treatment
- MRI in cancer diagnosis
- Fetal and Pediatric Neurological Disorders
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Brain Metastases and Treatment
- Spinal Dysraphism and Malformations
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
Niigata University
2014-2023
Niigata University Medical and Dental Hospital
2021
Hirosaki University
2020
University of California, Davis
1998-2017
Brain (Germany)
2015
GTx (United States)
2014
Central Brain Tumor Registry of the United States
2014
Toyama Prefectural Central Hospital
2011-2012
Kumamoto University
2012
Kurume University
2012
We conducted this study to determine, through use of multivariate analyses, the independent predictors hematoma enlargement occurring after hospital admission in patients with spontaneous intracerebral hemorrhage (i.c.h.).We reviewed 627 ICH admitted within 24 hours onset. The first CT was performed at and second admission, a blood sample taken for laboratory examinations. Univariate analyses were assess relationships between time from onset, consciousness level, findings, amount alcohol...
✓ In order to evaluate the incidence and risk factors of hematoma enlargement in spontaneous intracerebral hemorrhage (ICH), 419 cases ICH were reviewed. The first computerized tomography (CT) scan was performed within 24 hours onset second admission; a blood sample taken for laboratory examination 1 hour admission. 60 patients (14.3%) CT showed an enlarged hematoma. significantly decreased with time (p < 0.05) increased severity liver dysfunction volume on scan. Patients irregularly...
✓ To determine the incidence of, and risk factors for, occurrence of rebleeding between admission early operation (ultra-early rebleeding) in patients with spontaneous subarachnoid hemorrhage (SAH), authors reviewed cases 179 admitted within 24 hours after their last attack SAH. Thirty-one (17.3%) these had ultra-early despite scheduling (within admission). The significantly decreased as time interval increased. Patients before admission, high systolic blood pressure, intracerebral or...
In this paper, the authors' goal was to report their novel presurgical simulation method applying interactive virtual (IVS) using 3D computer graphics (CG) data and microscopic observation of color-printed plaster models based on these CG in surgery for skull base deep tumors.For 25 operations 23 patients with or intracranial tumors (meningiomas, schwannomas, epidermoid tumors, chordomas, others), authors carried out created by image analysis radiological data. Interactive performed...
Neuronal growth cones are essential for nerve and regeneration, as well the formation rearrangement of neural network. To elucidate phosphorylation-dependent signaling pathways establish useful molecular markers axon we performed a phosphoproteomics study mammalian cones, which identified >30,000 phosphopeptides ∼1,200 proteins. The phosphorylation sites were highly proline directed primarily MAPK dependent, owing to activation JNK, suggesting that proteins undergo proline-directed mediate...
Epithelioid glioblastoma is a rare aggressive variant of (GBM) characterized by dismal prognosis about 6 months and frequent leptomeningeal dissemination. A recent study has revealed that 50% epithelioid GBMs harbor three genetic alterations – BRAF V600E mutation, TERT promoter mutations, homozygous deletions CDKN2A/2B. Emerging evidence support the effectiveness targeted therapies for brain tumors with mutation. Here we describe dramatic radiographical response to combined therapy MEK...
Abstract BACKGROUND Microvascular decompression (MVD) is the most effective procedure for long-term management of trigeminal neuralgia (TGN). However, retrospective and single-center studies are inherently biased, there currently no prospective, multicenter studies. OBJECTIVE To evaluate short- outcomes complications in patients with TGN who underwent MVD at specialized Japanese institutions. METHODS We enrolled between April 2012 March 2015. recorded their facial pain grade 7 d (short...
Object. A systematic investigation on cortical reorganization in patients with hemiparesis of a subcortical origin, special emphasis functional correlates, was conducted using magnetic resonance (fMR) imaging performed 3-tesla system specifically optimized for fMR investigation. Methods. The study group included 46 (25 right and 21 left hemiparesis) 30 age-matched healthy volunteers as controls. All participants were originally handed. characteristics the lesion putaminal hemorrhage 19...
ABSTRACT BACKGROUND Microscopic application of magnetic resonance imaging (MRI) has entered the era clinical application. One most important targets is visualization pathological findings such as senile plaques (SP), in vivo , patients with Alzheimer's disease (AD). Such an provides not only accurate diagnostic tool for clinicians but also a solid basis scientists developing effective treatment and preventive strategies AD. METHODS Focused microscopic studies were performed on parietal...
The present study aimed to identify genes associated with patient survival improve our understanding of the underlying biology gliomas. We investigated whether expression selected using random forests models could be used define glioma subgroups more objectively than standard pathology. RNA from 32 non-treated grade 4 gliomas were analyzed GeneChip Human Genome U133 Plus 2.0 Expression array (which contains approximately 47 000 genes). Twenty-five whose expressions strongly and consistently...
The study objectives are (1) to identify factors predicting the excellent visual recovery after transsphenoidal removal of pituitary tumors and (2) describe association early restoration symmetry decompressed optic chiasm.Thirty-five patients with symptoms due underwent endoscopic endonasal surgery. All received perioperative diagnostic magnetic resonance (MR) imaging ophthalmological assessments within 2 weeks before surgery, 3 months or later Preoperative best-corrected acuity (BCVA ≧...
Previous magnetic resonance spectroscopy (MRS) and mass studies have shown accumulation of 2-hydroxyglutarate (2HG) in mutant isocitrate dehydrogenase (IDH) gliomas. IDH mutation is known to be a powerful positive prognostic marker malignant Hence, 2HG gliomas was assumed factor gliomas, but this has not yet been proven. Here, we analyzed 52 patients harboring World Health Organization (WHO) grade II III utilizing 3.0-tesla MRS.Mutant showed significantly higher (median 5.077 vs. 0.000, p...
Genetic and epigenetic status, including mutations of isocitrate dehydrogenase ( IDH ) TP 53 methylation O 6 ‐methylguanine‐DNA methyltransferase MGMT ), are associated with the development various types glioma useful for prognostication. Here, using routinely available histology sections from 312 patients diffuse gliomas, we performed immunohistochemistry antibodies specific I DH 1 mutation, aberrant p53 expression to evaluate possible prognostic significance these features. With regard...
Abstract Purpose: Molecular targeted therapy using BRAF and/or MEK inhibitors has been applied to BRAFV600E-mutant high-grade gliomas (HGG); however, the therapeutic effect is limited by emergence of drug resistance. Experimental Design: We established multiple paired HGG patient-derived xenograft models based on tissues collected prior and at relapse after molecular therapy. Using these models, we dissected treatment-resistant mechanisms for explored targets overcome resistance in BRAFV600E...
Object. Histopathological studies indicate that cerebral edema associated with tumors (peritumoral edema) does not represent a single pathophysiological or clinical entity. In this study the authors investigated peritumoral by performing lambda chart analysis (LCA), noninvasive technique can be used to make visible and analyze apparent water diffusivity in tissues vivo, assessed utility of LCA differentiating high-grade gliomas from nonglial tumors. Methods. The characteristics four tumor...
Transvenous embolization (TVE) for the treatment of a cavernous sinus (CS) dural arteriovenous fistula (DAVF) occasionally causes cranial nerve palsy (CNP). Overpacking coils is considered to result in CNP. The purpose this study was analyze association TVE-induced CNP with volume and location activated CS.Thirty-one patients CS DAVFs (33 lesions) underwent TVE.Cranial occurred or aggravated 13 cases (39.4%; group). cumulative significantly greater group (0.241 +/- 0.172 cm3) than non-CNP...
Autophagy is a dynamic process of protein degradation. Induction autophagy by temozolomide (TMZ) has been noted in glioma cell lines. Twenty‐eight specimens, obtained from 14 patients before and after TMZ treatment, were analyzed to investigate whether induction could be detected surgical specimens immunohistochemical analysis. Macroautophagy was monitored analysis employing anti‐light chain 3 isoform B (LC3B) anti‐lysosome‐associated membrane 1 (LAMP1) antibodies; chaperone‐mediated...
The authors retrospectively analyzed various clinicopathological factors to determine which are related regrowth during a long-term follow-up period in patients who underwent incomplete vestibular schwannoma (VS) resection.This study involved 74 (25 men and 49 women) whom VS was treated surgically via the lateral suboccipital approach, had postoperative periods exceeding 5 years. mean 104.1 months (range 60-241 months), patient age at surgery 48.1 years 19-75 years). tumors ranged size from...
BACKGROUND: Despite recent diagnostic and technical advancements in the field of neurosurgery, surgical treatment for tumors skull base region, ie, (SBTs), remains a challenge. OBJECTIVE: To validate utility presurgical simulation SBTs by 3-dimensional multifusion volumetric imaging (3D MFVI), including volume rendering image fusion, to combine data from various modalities. METHODS: We performed using 3D MFVI 21 (acoustic neurinomas, jugular meningiomas, chordomas, others) 20 patients....
Biopsy is the gold standard for diagnosis of primary CNS lymphoma (PCNSL). However, surgical biopsy has problems morbidity related to hemorrhagic complications and false-negative findings, so safer more reliable diagnostic methods are required. The aim this study detect MYD88 mutation, an important driver in cerebrospinal fluid (CSF) patients with lymphoma.Twenty-six (20 six relapse from systemic lymphoma) were studied. We extracted cell-free DNA (cfDNA) CSF by lumbar puncture. cfDNA was 1...