A5018207243- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Heat shock proteins research
- Signaling Pathways in Disease
- FOXO transcription factor regulation
- Neuroscience and Neuropharmacology Research
- CNS Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Pregnancy-related medical research
- Chronic Kidney Disease and Diabetes
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Renal Diseases and Glomerulopathies
- Venous Thromboembolism Diagnosis and Management
- Neonatal and fetal brain pathology
- Brain Metastases and Treatment
- Cerebrospinal fluid and hydrocephalus
- Renin-Angiotensin System Studies
- Melanoma and MAPK Pathways
- Amino Acid Enzymes and Metabolism
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Folate and B Vitamins Research
Yokohama City University
2014-2025
University of Pittsburgh Medical Center
2023-2025
Yokohama City University Hospital
2021-2024
Kyushu University
2021-2024
Neurological Surgery
2024
University of Pittsburgh
2024
Shizuoka City Hospital
2024
Shizuoka University of Welfare
2013-2023
Hudson Institute
2020
National Center of Neurology and Psychiatry
2017-2019
Abstract Purpose: Molecular targeted therapy using BRAF and/or MEK inhibitors has been applied to BRAFV600E-mutant high-grade gliomas (HGG); however, the therapeutic effect is limited by emergence of drug resistance. Experimental Design: We established multiple paired HGG patient-derived xenograft models based on tissues collected prior and at relapse after molecular therapy. Using these models, we dissected treatment-resistant mechanisms for explored targets overcome resistance in BRAFV600E...
Relaxin, a pregnancy hormone, has antiapoptotic and anti-inflammatory properties. The aim of this study was to determine the effects relaxin on ischemia-reperfusion (IR)-induced acute kidney injury. Male rats underwent unilateral nephrectomy contralateral renal IR (45 min pedicle clamping). Rats were divided into three groups: 1) sham group, 2) 3) IR-RLX group (rats treated with before ischemia). In infused at 500 ng/h via subcutaneous osmotic minipump for 24 h beginning 2 ischemia. At after...
The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs. In focal-onset seizures, an increase in AMPAR trafficking augments amplitude abnormal gamma activity detected by electroencephalography. contrast,...
Abstract In patients with drug‐resistant epilepsy (DRE) who are not candidates for resective surgery, various thalamic nuclei, including the anterior, centromedian, and pulvinar have been extensively investigated as targets neuromodulation. However, therapeutic effects of different neuromodulation on types well understood. Here, we present a 32‐year‐old patient multifocal bilateral temporoparieto‐occipital malformations cortical development (MCDs) underwent stereoelectroencephalographic...
Abstract Objective Recent studies highlight the amygdala's crucial role in temporal lobe epilepsy (TLE), particularly magnetic resonance imaging‐negative cases and new TLE subtypes with structural amygdala changes. This study aims to investigate electrophysiological properties connectivity patterns of amygdaloid complex patients using stereoelectroencephalography (SEEG). Methods From March 2020 December 2023, we collected data from nine drug‐resistant who underwent SEEG dual trajectories:...
INTRODUCTION: Surgical intervention for medically-refractory temporal lobe epilepsy (TLE) is predicated on the delineation of epileptogenic zone. In selected patients, anatomo-electroclinical hypotheses are explored by SEEG methodology. Conventional classification systems have divided TLE into mesial and lateral (or neocortical) epilepsy. However, this does not account numerous cytoarchitectonic regions functionally distinct networks housed in connected structures. METHODS: We collected...
In this study, the authors evaluated cerebral atrophy in 56 chronic hemodialyzed patients, who did not have clinical episodes or radiologic findings of cerebrovascular diseases, and 42 controls. Using computed tomography (CT) images, brain index (BAI), proportion subarachnoidal plus ventricular space cranial cavity, area (VAI), percent ventricle brain, were calculated. CT demonstrated an age-dependent increase BAI both patients VAI greater than healthy controls difference was significant at...
Background. In the general population, aging induces changes in body composition, such as sarcopenia or a relative increase visceral fat, but it remains unclear if similar occur elderly haemodialysis (HD) patients. Methods. Age-related muscle and fat mass distribution thigh abdomen were cross-sectionally investigated Japanese HD The area (TMA), intermuscular (IMFA), subcutaneous (TSFA), abdominal (AMA), (AVFA) (ASFA) measured by computed tomography 134 non-diabetic patients between 21 82...
Abstract Background Cisplatin (CP) is an extremely effective anticancer agent widely used to treat various cancer types, however, the potential side effects include testicular dysfunction. This study was investigate, using a rat model of CP-induced dysfunction, protective relaxin (RLN) against oxidative stress, function, histological damage, spermatogenesis, germ-cell apoptosis, and sperm output, explore usefulness RLN as drug for use with CP in chemotherapeutic treatments. Methods...
Primary central nervous system lymphoma (PCNSL) is an isolated type of the and has a dismal prognosis despite intensive chemotherapy. Recent genomic analyses have identified highly recurrent mutations MYD88 CD79B in immunocompetent PCNSL, whereas LMP1 activation commonly observed Epstein-Barr virus (EBV)-positive PCNSL. However, lack clinically representative preclinical models hampered our understanding pathogenic mechanisms by which genetic aberrations drive PCNSL disease phenotypes. Here,...
Although relaxin (RLX) has potent vasodilatory and anti-fibrotic properties, there is no information on its effects salt-sensitive hypertension. We investigated the of short-term treatment with RLX blood pressure (BP) nitric oxide synthase (NOS) protein in kidneys male Dahl (DS) salt-resistant (DR) rats after 1 week consumption an 8% NaCl diet. also evaluated inhibitory each specific NOS inhibitor BP during 1-week under high-salt Next, we examined long-term for 6 weeks renal histology...
<h3>BACKGROUND AND PURPOSE:</h3> The transmantle sign is a characteristic MR imaging finding often seen in focal cortical dysplasia type IIb. typically hyperintense on T2WI and FLAIR hypointense T1WI. However, some cases, it shows T1 high signal. We evaluated the pathologic findings to identify causes of signal sign. <h3>MATERIALS METHODS:</h3> retrospectively reviewed preoperative data 141 consecutive patients with histologically proved dysplasia. selected 25 divided them into groups based...
Pediatric epilepsy surgery is known to be effective, but early in infancy not well characterized. Extensive cortical dysplasia, such as hemimegalencephaly, can cause refractory shortly after birth, and surgical intervention indicated. However, the complication rate of pediatric significant. In this study, authors assessed risk-benefit balance relates developmental outcomes.
Protein and mRNA expression of transforming growth factor-beta (TGF-beta) receptor type I (TbetaRI), II (TbetaRII), III (TbetaRIII) were studied in serial sections kidney samples obtained from patients with glomerulonephritis. In minimal change disease, weak TbetaRI TbetaRII was observed mainly glomerular endothelial cells, peritubular capillaries, interstitial arteriolar whereas TbetaRIII found the interstitium. Expression all three TGF-beta receptors (TbetaR) increased remarkably Bowman's...
Abstract We present a case of 14-year old boy with tumor-associated refractory epilepsy. Positron emission tomography imaging demonstrated region heterogeneous high 11 C-methionine uptake and homogenous low 18 F-fluorodeoxyglucose within the tumor. Histopathological genomic analyses confirmed tumor as BRAF V600E-mutated polymorphous low-grade neuroepithelial young (PLNTY). Within high-methionine-uptake region, we observed increased protein levels L-type amino acid transporter 1 (LAT1), major...
Cognitive risk associated with insular cortex resection is not well understood. The authors reviewed cognitive and developmental outcomes in pediatric patients who underwent of the epileptogenic zone involving insula.
Abstract. The issue of whether recombinant human erythropoietin (rhEPO) increases thrombosis arteriovenous (AV) fistulae used for hemodialysis remains unclear. Thrombosis often occurs at stenotic segments where there is marked intimal hyperplasia and extracellular matrix accumulation. Increased expression transforming growth factor-β1 (TGF-β1) has been shown to be involved in the development atherosclerotic lesions by promoting To clarify role rhEPO stenosis AV fistulae, this study examined...