A5020749919- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Parathyroid Disorders and Treatments
- Renin-Angiotensin System Studies
- TGF-β signaling in diseases
- Electrolyte and hormonal disorders
- Hormonal Regulation and Hypertension
- Renal and related cancers
- Muscle and Compartmental Disorders
- Complement system in diseases
- Gout, Hyperuricemia, Uric Acid
- Regulation of Appetite and Obesity
- Chemotherapy-induced organ toxicity mitigation
- Drug-Induced Hepatotoxicity and Protection
- Autoimmune Bullous Skin Diseases
- Vitamin D Research Studies
- Platelet Disorders and Treatments
Teikyo University
2016-2025
Teikyo University Hospital
2014-2024
Hamamatsu University Hospital
2022
Japanese Society of Nephrology
2019-2020
Hamamatsu University School of Medicine
2007-2018
National Taiwan University Hospital
2013
Songjiang District Central Hospital
2013
Universitätsklinikum Würzburg
2013
Catholic University of Korea
2013
Carmel Medical Center
2013
<h3>Importance</h3> The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated vasculitis is the combination of high-dose glucocorticoids and cyclophosphamide or rituximab. Although these regimens have high remission rates, they are associated with considerable adverse events presumably due to glucocorticoids. <h3>Objective</h3> To compare efficacy between a reduced-dose glucocorticoid plus rituximab regimen in ANCA-associated vasculitis. <h3>Design,...
Overexpression of transforming growth factor β (TGF-β) has been shown to play pathogenic roles in progression renal fibrosis, and the severity tubulointerstitial fibrosis correlates better with function than glomerulosclerosis. Smad proteins are signaling transducers downstream from TGF-β receptors. Three families have identified: receptor-regulated Smad2 Smad3, common partner Smad4, inhibitory Smad7 (part a negative-feedback loop). We investigated Smad-mediated pathway regulatory mechanisms...
In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in deterioration of renal function, but it difficult to measure it. For assessment the potential urinary angiotensinogen as a marker AngII activity, correlation plasma and renin-angiotensin system components, including angiotensinogen, with function was investigated 80 patients who had CKD were not treated blocking agents. Changes that induced by 14 d losartan treatment (25 mg/d) also measured 28...
Toll-like receptor 9 (TLR9) contributes to the development of polymicrobial septic AKI. However, mechanisms that activate TLR9 pathway and cause kidney injury during sepsis remain unknown. To determine role mitochondrial DNA (mtDNA) in TLR9-associated AKI, we established a cecal ligation puncture (CLP) model wild-type (WT) Tlr9 -knockout ( KO) mice. We evaluated systemic circulation peritoneal cavity dynamics immune response tubular dysfunction upstream downstream effects on pathway,...
The clinical use of cisplatin (cis-diamminedichloro-platinum II, CDDP) is highly limited by its nephrotoxicity. Although N-acetylcysteine (NAC), a thiol-containing antioxidant, has been documented to be effective in attenuating renal injury induced CDDP, the precise mechanisms involved renoprotection have not completely clarified.We investigated effects NAC on oxidative stress and oxidation-associated signals, such as p38 mitogen-activated protein kinase (MAPK), NF-kappaB TNF-alpha,...
Objectives Owing to recent changes in our understanding of the underlying cause chronic kidney disease (CKD), importance lifestyle modification for preventing progression dysfunction and complications has become obvious. In addition, effective cooperation between general physicians (GPs) nephrologists is essential ensure a better care system CKD treatment. this cluster-randomized study, we studied effect behavior on outcome early- moderate-stage CKD. Design Stratified open trial. Setting A...
Abstract. The goal of this study was to clarify the role p21, a cyclin-dependent kinase inhibitor, in acute renal failure (ARF). This accomplished with examination expression p21 cisplatin (CDDP)-induced ARF and rechallenge injury CDDP. injection CDDP (5 mg/kg) into rats induced increases serum creatinine tubular damage number situ DNA nick end labeling—positive cells, which peaked at day 5, followed by recovery control levels 14. same dose 14 d after first significantly less no significant...
Significance Calcineurin inhibitors (CNIs) are potent immunosuppressants; hypertension and hyperkalemia common adverse effects. Activation of the renal Na-Cl cotransporter (NCC) is implicated in this toxicity; however, mechanism unknown. CNIs’ effects mimic resulting from mutations WNK kinases or KLHL3-CUL3 ubiquitin ligase. WNKs activate NCC degraded by ubiquitylation upon their binding to KLHL3. The KLHL3 prevented PKC-mediated phosphorylation at serine 433. This work shows that...
Background The role of uric acid (UA) in the progression chronic kidney disease (CKD) remains controversial due to unavoidable cause and result relationship. This study was aimed clarify independent impact UA on subsequent risk end-stage renal (ESRD) by a propensity score analysis. Methods A retrospective CKD cohort used (n = 803). Baseline 23 covariates were subjected multivariate binary logistic regression with targeted time-averaged 6.0, 6.5 or 7.0 mg/dL. participants trimmed 2.5...
A 63-year-old Japanese housewife was admitted to our hospital because of hematuria and proteinuria lasting for 3 months. At the age 59 years, she diagnosed with neurosarcoidosis at another hospital, received oral glucocorticoid therapy 1 year. Her serum angiotensin-converting enzyme (ACE) 1, 25-dihydroxyvitamin D levels were elevated. Computed tomography showed lymphadenopathy tracheal bifurcation diffuse nodular shadow in lungs liver. Renal biopsy findings compatible IgA nephropathy without...
Objective Adiponectin (ADPN) has been shown to protect against cardiovascular disease for the general population with problematic metabolic syndrome. However, it remains unclear whether ADPN is associated mortality in patients on maintenance hemodialysis (HD). Methods, Patients or Materials We selected 85 HD [51 men/34 women; mean age, 64±2 years; underlying kidney diseases, diabetic nephropathy 36 (42.3%), chronic glomerulonephritis 29 (34.1%), hypertensive nephrosclerosis 10 (11.8%), and...
Background A goal of searching risk factors for chronic kidney disease (CKD) is to halt progressing end-stage renal (ESRD) by potential intervention. To predict the future ESRD, 30% decline in estimated GFR over 2 years was examined comparison with other time-dependent predictors. Methods CKD patients who had measurement serum creatinine at baseline and were enrolled (n = 701) followed up 6 years. Time-dependent parameters calculated as time-averaged values a trapezoidal rule. Risk affecting...
Establishment of non-invasive urinary biomarkers for the prediction acute renal failure (ARF) is important. We evaluated whether oxidative stress markers reflect intrarenal in cisplatin (CDDP)-induced ARF, and these can be used future ARF.Urinary malondialdehyde (MDA) 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured up to day 14 post-CDDP (6 mg/kg) injection rats. MDA 8-OHdG expressions examined kidneys.CDDP induced an increase serum creatinine (Scr), blood urea nitrogen (BUN), tubular...
Significance Statement Patients with type 2 diabetes often exhibit salt-sensitive hypertension, but the mechanisms underlying this association remain unclear. One potential link, Kelch-like 3 (KLHL3), regulates BP by targeting serine/threonine kinases with-no-lysines (WNKs) for degradation, thereby modulating activity of NaCl cotransporter (NCC). The authors previously found that phosphorylation at serine 433 (S433) in KLHL3 downregulates activity. In study, they show protein kinase...
Smad ubiquitination regulatory factor 2 (Smurf2), a ubiquitin ligase for Smads, plays critical roles in the regulation of transforming growth factor‐β (TGF‐β)‐Smad signaling via ubiquitin‐dependent degradation Smad2 and Smad7. We found that TGF‐β stimulates Smurf2 expression. activated promoter responsive cell lines, whereas IL‐1α, PDGF epidermal did not. TGF‐β‐mediated activation was inhibited by Smad7 or an activin receptor‐like kinase 5 inhibitor but not dominant negative disruption...
Background. We examined kinetics and characterization of regenerating proximal tubule (PT) cells after various degrees tubular injury in S3 segments PT assessed label-retaining slow cycling S3. Methods. was induced by different doses uranyl acetate (UA) injection into rats, initially PTs were identified vivo bromodeoxyuridine (BrdU)-labelling before sacrifice or on vimentin positivity. Next, the 3H-thymidine pulse/chase approach applied to early BrdU-labelling UA injection. Results. Low-dose...
Background Although hyperphosphatemia is deemed a risk factor of the progression chronic kidney disease (CKD), it remains unclear whether normal range serum phosphorus likewise deteriorates CKD. A propensity score analysis was applied to examine causal effect on incidence end-stage renal (ESRD). Methods retrospective CKD cohort 803 participants in single institution analyzed. Propensity estimated using 22 baseline covariates by multivariate binary logistic regression for different thresholds...