A5025368668- Vasculitis and related conditions
- IgG4-Related and Inflammatory Diseases
- Asthma and respiratory diseases
- Seed Germination and Physiology
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Cancer Immunotherapy and Biomarkers
- Flowering Plant Growth and Cultivation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Migraine and Headache Studies
- Chemotherapy-related skin toxicity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunotherapy and Immune Responses
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Bioactive Compounds and Antitumor Agents
- Leaf Properties and Growth Measurement
- Renal Diseases and Glomerulopathies
- CNS Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders Research
International University of Health and Welfare
2020-2024
Japanese Red Cross Narita Hospital
2018-2020
Chiba University
2011-2020
Asahi General Hospital
2017
Chiba University Hospital
2013
Ministry of Health Labour and Welfare
2013
Twin Cities Orthopedics
1994
University of Minnesota
1994
<h3>Importance</h3> The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)–associated vasculitis is the combination of high-dose glucocorticoids and cyclophosphamide or rituximab. Although these regimens have high remission rates, they are associated with considerable adverse events presumably due to glucocorticoids. <h3>Objective</h3> To compare efficacy between a reduced-dose glucocorticoid plus rituximab regimen in ANCA-associated vasculitis. <h3>Design,...
Helios+FoxP3+CD4+ (Helios+) Treg cells are believed to be involved in the regulation of various autoimmune diseases; however, regulatory mechanisms underlying development Helios+ remain uncertain. This study was undertaken elucidate Helios expression CD4+ T and its roles transforming growth factor β (TGFβ)-induced cell function.We examined patients with rheumatoid arthritis by DNA microarray analysis before after treatment biologic agents. We also effect interleukin-6 (IL-6) TGFβ on humans...
The tumor suppressor p53 plays a central role in suppression by inducing apoptosis, cell cycle arrest, senescence, and DNA repair. In addition to the antitumor functions of p53, accumulating evidence using systemic p53-deficient mice suggests that suppresses autoimmunity. However, it remains unknown how this study, we generated T cell-specific (CD4-Cre p53(fl/fl) mice, or conditional knockout [cKO] mice) found aged p53-cKO spontaneously developed inflammatory lesions various organs,...
Objective. Our prospective study aimed to demonstrate that the cumulative synovial power Doppler (PD) ultrasound scores correlate with radiographic progression better than conventional measures in patients rheumatoid arthritis (RA). We also investigated difference between antirheumatic agents. Methods. Sixty-nine RA who had recently received either methotrexate (MTX; n = 23), tumor necrosis factor (TNF) antagonists (n 28), or tocilizumab (TCZ; 18) were enrolled. Patients underwent clinical,...
<i>Background:</i> Mast cells are immunocompetent that found in almost all tissues and function as sentinels of immune responses. Recently, it has been shown mast play significant roles innate However, is still largely unknown whether signal transducers activators transcription 4 (STAT4), one the STAT proteins under type I IFN signaling, involved IFN-mediated gene expression cells. <i>Methods:</i> We investigated role STAT4 IFN-β-induced by using STAT4-deficient...
Abstract Dendritic cells (DCs) play critical roles in determining the fate of CD4+ T cells. Among DC sub-populations, monocyte-derived inflammatory DCs (iDCs) have been shown to an important role induction adaptive immune responses under conditions. Although previous studies that indispensable allergic airway inflammation and hyperreactivity (AHR) murine asthma models, precise iDCs asthmatic remain largely unknown. We show here Th2 cell-mediated models induces expression some markers...
Histoplasmosis, a fungal infection caused by Histoplasma capsulatum, is endemic in many parts of the world. However, this not common Japan. We herein present unique case military histoplasmosis 45-year-old female with mixed connective tissue disease (MCTD) who was receiving immunosuppressive therapy. The histological findings coupled molecular confirmation led to final diagnosis. This emphasizes diagnostic challenges associated immunocompromised patients and underscores importance...
An 87-year-old woman presented with a 3-month history of fever, edema the lower legs, and gait disturbance. A laboratory examination revealed high serum levels myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA). Although microscopic polyangiitis was initially suspected treated, patient subsequently developed transient hemiparesis disturbed consciousness. Brain magnetic resonance imaging/angiography infarct-like lesions, pachymeningeal involvement, diffuse cerebral...
ISHS VII International Symposium on Protected Cultivation in Mild Winter Climates: Production, Pest Management and Global Competition THE EFFECTS OF HIGH TEMPERATURE AND SALINITY STRESS ON SUMMER SINGLE-TRUSS TOMATO CULTIVATION
Objective We aimed to determine the prevalence and risk factors for osteonecrosis of femoral head (ONFH) in a multicentre cohort patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Methods One hundred eighty-six AAV who underwent radiographs MRI screening bilateral hip joints at more than 6 months after initial remission induction therapy (RIT) were retrospectively assessed presence ONFH. Results Among 186 patients, 33 (18%) diagnosed ONFH, 55% asymptomatic 64% had...
<h3>Background:</h3> Ultraviolet (UV) radiation has been identified as a risk factor for disease onset and flares in patients with systemic lupus erythematosus (SLE). Excessive production of type I interferon (IFN), particularly IFN-κ, occurs locally the skin SLE, is considered to contribute exacerbation cutaneous manifestations induced by UV [1]. exposure also implicated not only exposed areas but worsening non-exposed other organs [2]. In addition, an increase circulating IFN, especially...
We present the case of a 57-year-old male with history smoking, hypertension, dyslipidemia, and migraines who experienced one-month dyspnea headaches, followed by sudden-onset altered consciousness. Initial imaging ruled out cerebrovascular infectious etiologies, arterial blood gas analysis revealed severe hypercapnia hypoxemia (partial pressure carbon dioxide: 117 mmHg, partial oxygen: 111 mmHg under 10 L/min oxygen mask). The patient's condition improved mechanical ventilation, resulting...
Peripheral ulcerative keratitis (PUK) is a non-infectious ulcer at the peripheral corneal stroma. Autoimmune diseases can cause PUK, but PUK caused by large vessel vasculitis (LVV) has rarely been reported. We report case of 71-year-old woman with complaints low-grade fever and left eye pain. Ophthalmologic examination revealed in eye, we diagnosed LVV 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) findings. The patient was treated topical betamethasone drops for oral...
<h3>Background</h3> Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis presents with various symptoms. ANCA-associated hypertrophic pachymeningitis (HP) is a very rare pathology. <h3>Objectives</h3> This study aimed to investigate the efficacy of rituximab (RTX) against patients ANCA-related HP. <h3>Methods</h3> Seven were identified by retrospective chart review from local registries at four Hospitals in Japan. All met Chapel Hill 2012 Consensus Conference definitions...