A5101814494- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Pregnancy and preeclampsia studies
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Vasculitis and related conditions
- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Systemic Lupus Erythematosus Research
- Eicosanoids and Hypertension Pharmacology
- Ion channel regulation and function
- Gestational Diabetes Research and Management
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- Diabetes and associated disorders
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cancer-related Molecular Pathways
- Chemotherapy-induced organ toxicity mitigation
- Porphyrin and Phthalocyanine Chemistry
- Pharmacological Effects of Natural Compounds
- Gout, Hyperuricemia, Uric Acid
- Reproductive System and Pregnancy
Fujieda Municipal General Hospital
2016-2023
Numazu City Hospital
2012-2021
Nihon University Itabashi Hospital
2019-2021
Hamamatsu University
2008-2012
Yamamoto Hospital
2012
Hamamatsu University School of Medicine
1999-2011
Nihon University
2009
Health First
2002-2007
Nagoya Institute of Technology
1994-2001
Teikyo University
1990-2000
In chronic kidney disease (CKD), enhanced intrarenal angiotensin II (AngII) is involved in deterioration of renal function, but it difficult to measure it. For assessment the potential urinary angiotensinogen as a marker AngII activity, correlation plasma and renin-angiotensin system components, including angiotensinogen, with function was investigated 80 patients who had CKD were not treated blocking agents. Changes that induced by 14 d losartan treatment (25 mg/d) also measured 28...
Endothelin (ET) receptor blockade delays the progression of diabetic nephropathy; however, mechanism this protection is unknown. Therefore, aim study was to test hypothesis that ET(A) attenuates superoxide production and inflammation in kidney rats. Diabetes induced by streptozotocin (diabetic rats with partial insulin replacement maintain modest hyperglycemia [HG]), sham received vehicle treatments. Some also ETA antagonist ABT-627 (sham+ABT HG+ABT; 5 mg/kg per d; n = 8 10/group). During...
Current diagnostic criteria have limited clinical value for prediction of preeclampsia and fetal adverse outcomes. The short-term outcome in pregnant women with suspected study Asia (PROGNOSIS Asia) was a prospective, multicenter designed to investigate the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor) ratio predicting outcomes Asian preeclampsia. Seven hundred sixty-four at gestational week 20+0 days (18+0 Japan) 36+6 were enrolled 25 sites Asia. primary...
Helicobacter pylori infection is a risk factor for gastric carcinogenesis. High dietary vitamin C intake appears to protect against carcinoma. It has been suggested that exerts the protective effect by scavenging free radicals may be enhanced H. pylori. However, not investigated in relation direct action on In this study, authors attempted clarify possibility both vitro and vivo.Susceptibility testing of (64 strains) was performed agar dilution method. Bactericidal actions were determined...
Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although molecular mechanisms responsible unknown. We hypothesize that differential activation II, (1-7), type 1, 2, and mas levels in renal cortex male female spontaneously rats contribute sex differences blood pressure response infusion. Males had a greater increase after infusion than females (males: 150±2 186±3 mm Hg; females: 137±3 160±4 P<0.05). Angiotensin resulted comparable increases plasma...
Establishment of non-invasive urinary biomarkers for the prediction acute renal failure (ARF) is important. We evaluated whether oxidative stress markers reflect intrarenal in cisplatin (CDDP)-induced ARF, and these can be used future ARF.Urinary malondialdehyde (MDA) 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured up to day 14 post-CDDP (6 mg/kg) injection rats. MDA 8-OHdG expressions examined kidneys.CDDP induced an increase serum creatinine (Scr), blood urea nitrogen (BUN), tubular...
Nitric oxide is a critical regulator of blood pressure (BP) and inflammation, female spontaneously hypertensive rats (SHR) have higher renal nitric bioavailability than males. We hypothesize that SHR will greater rise in BP T cell infiltration response to synthase (NOS) inhibition Both male displayed dose-dependent increase the nonspecific NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME: 2, 5, 7 mg·kg(-1)·day(-1) for 4 days each); however, females exhibited Treatment with L-NAME 2...
Although relaxin (RLX) has potent vasodilatory and anti-fibrotic properties, there is no information on its effects salt-sensitive hypertension. We investigated the of short-term treatment with RLX blood pressure (BP) nitric oxide synthase (NOS) protein in kidneys male Dahl (DS) salt-resistant (DR) rats after 1 week consumption an 8% NaCl diet. also evaluated inhibitory each specific NOS inhibitor BP during 1-week under high-salt Next, we examined long-term for 6 weeks renal histology...
Abstract Two prospective multicenter studies demonstrated that a soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio cutoff of ≤38 can rule out preeclampsia within week with negative predictive value (NPV) 99.3% (PROGNOSIS) and 98.6% (PROGNOSIS Asia). We report subanalysis the Japanese cohort from PROGNOSIS Asia study. Pregnant women suspected between gestational weeks 18 + 0 days 36 6 were enrolled at eight sites. Primary objectives: Assess performance Elecsys ®...
It has been reported that the binding of some antiphospholipid antibodies (APA) to phospholipids requires presence beta 2-glycoprotein I (beta 2-GPI). Using a new ELISA, in which well coated were treated with constant amount purified 2-GPI, we tried detect APA binds phospholipid/beta 2-GPI complex or such as cardiolipin (CA) and phosphatidylserine (PS) preeclampsia, check for clinical abnormalities antibody-positive cases. Serum samples taken from 43 cases including 26 severe type, 47 normal...
We investigate the mechanism(s) of plasma glucose lowering action puerarin in streptozotocin-induced diabetic rats (STZ-diabetic rats). Puerarin at effective dosage to lower higher increased β-endorphin-like immunoreactivity (BER) STZ-diabetic rats. Both effects were abolished by pretreatment with prazosin. Also, enhanced BER release from isolated rat adrenal medulla a concentration-dependent manner that can be Moreover, bilateral adrenalectomy eliminated actions including effect and...
Abstract. The issue of whether recombinant human erythropoietin (rhEPO) increases thrombosis arteriovenous (AV) fistulae used for hemodialysis remains unclear. Thrombosis often occurs at stenotic segments where there is marked intimal hyperplasia and extracellular matrix accumulation. Increased expression transforming growth factor-β1 (TGF-β1) has been shown to be involved in the development atherosclerotic lesions by promoting To clarify role rhEPO stenosis AV fistulae, this study examined...
The differential roles of circulating and intrarenal renin-angiotensin system (RAS) in glomerulonephritis have not been elucidated. In this study, we investigated the levels RAS activity urinary angiotensinogen (AGT) excretion anti-thymocyte serum (ATS) nephritis induced by an ATS injection (ATS group). effect olmesartan, angiotensin II (ANG II) type 1 receptor blocker (ARB), on development was also examined (ATS+ARB addition, rats received a saline instead (control Mesangial proliferation...
Despite suppression of the circulating renin-angiotensin system (RAS), high salt intake (HSI) aggravates kidney injury in chronic disease. To elucidate effect HSI on intrarenal RAS, we investigated levels prorenin, renin, (pro)renin receptor (PRR), receptor-mediated prorenin activation, and ANG II anti-thymocyte serum (ATS) nephritic rats HSI. Kidney fibrosis grew more severe than normal intake. plasma renin II, marked increases tubular proteins without concomitant rises mRNA,...
A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies structure assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is first example a natural possessing saturated ring moiety. The confirmed by chemical transformation known D (2) to T.