A5004039696- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Maternal and Perinatal Health Interventions
- Preterm Birth and Chorioamnionitis
- Ectopic Pregnancy Diagnosis and Management
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- MicroRNA in disease regulation
- Pregnancy-related medical research
- Uterine Myomas and Treatments
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
- Extracellular vesicles in disease
- Pregnancy and Medication Impact
- Cardiac Arrhythmias and Treatments
- Endometriosis Research and Treatment
- Gestational Trophoblastic Disease Studies
- Reproductive tract infections research
- Neurological Complications and Syndromes
- Venous Thromboembolism Diagnosis and Management
Jichi Medical University
2016-2025
Jichi Medical University Hospital
2014-2025
Hypertension Institute
2023
United States Congress
2023
Tokyo University of Agriculture
2021
Tokyo Women's Medical University
2011
Ashikaga Red Cross Hospital
2011
Nippon Medical School
2011
Harbin Medical University
2011
The University of Tokyo
2009
In this study, we performed small RNA library sequencing using human placental tissues to identify placenta-specific miRNAs. We also tested the hypothesis that chorionic villi could secrete miRNAs extracellularly via exosomes, which in turn enter into maternal circulation. By sequencing, most (e.g., MIR517A) were linked a miRNA cluster on chromosome 19. The genes differentially expressed development. Subsequent validation by real-time PCR and situ hybridization revealed villous trophoblasts...
Abstract The ‘ C linical G uidelines for O bstetrical P ractice, 2011 edition’ were revised and published as a 2014 edition (in J apanese) in A pril by the apan S ociety of bstetrics ynecology ssociation bstetricians ynecologists. aims this publication include determination current standard care practices pregnant women apan, widespread use practices, enhancement safety obstetrical practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding...
Abstract Clinical guidelines for obstetrical practice were first published by the Japan Society of Obstetrics and Gynecology (JSOG) Association Obstetricians Gynecologists (JAOG) in 2008, a revised version was 2011. The aims this publication include determination current standard care practices pregnant women Japan, widespread use practices, enhancement safety practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding between maternity‐service...
In this study, to search for novel preeclampsia (PE) biomarkers, we focused on microRNA expression and function in the human placenta complicated with PE. By comprehensive analyses of expression, identified 22 microRNAs significantly upregulated preeclamptic placentas, 5 which were predicted silico commonly target mRNA encoding hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1), a steroidogenetic enzyme expressed predominantly placenta. vivo HSD17B1 at both protein levels, was decreased...
For cesarean hysterectomy with placenta previa accreta, "universally achievable" measures are required. We propose eight measures: (i) placement of intra-iliac arterial occlusion balloon catheters; (ii) ureter stents; (iii) "holding the cervix" to identify site be transected; (iv) uterine fundal incision; (v) avoidance uterotonics; (vi) "M cross double ligation" for ligating ovarian ligament; (vii) "filling bladder" bladder separation and "opening accreta invasion; (viii) continue clamp...
Current diagnostic criteria have limited clinical value for prediction of preeclampsia and fetal adverse outcomes. The short-term outcome in pregnant women with suspected study Asia (PROGNOSIS Asia) was a prospective, multicenter designed to investigate the sFlt-1 (soluble fms-like tyrosine kinase 1)/PlGF (placental growth factor) ratio predicting outcomes Asian preeclampsia. Seven hundred sixty-four at gestational week 20+0 days (18+0 Japan) 36+6 were enrolled 25 sites Asia. primary...
During pregnancy, human placenta-associated microRNAs (miRNAs) derived from the miRNA cluster in chromosome 19 are expressed villous trophoblasts and secreted into maternal circulation via exosomes; however, little is known about whether circulating miRNAs transferred immune cells exosomes, modulate expression of target genes recipient cells. We employed an vitro model trophoblast-immune cell communication using BeWo (a trophoblast line) Jurkat leukemic T-cell investigated exosomal can...
Abstract Aim In placenta previa ( PP ), anterior placentation, compared with posterior is reported to more frequently cause massive hemorrhage during cesarean section CS ). Whether this due the high incidence of accreta, previous , or a transplacental approach in unclear. We attempted clarify issue. Material and Methods retrospectively analyzed relation between bleeding amount for various factors that may (>2400 m L ) n = 205) tertiary center. If preoperatively ultrasound‐measured...
Despite the increasing commercial use of nanoparticles, little is known about their effects on placental inflammation and pregnancy complications. In this study, nanosilica (NS) particles upregulated inflammasome component nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) induced reactive oxygen species (ROS) generation, resulting in Furthermore, NS-induced complications were markedly improved Nlrp3−/− mice but not apoptosis-associated...
The first aim of our study was to develop a pregnant mouse model for preeclampsia using adenoviral vector containing full-length soluble fms-like tyrosine kinase 1 (sFlt-1) but not truncated sFlt-1. second evaluate effects recombinant (rm) vascular endothelial growth factor (VEGF) and rm placental (PlGF) on induced by We injected sFlt-1 day 8.5 or 9.5 gestation into Institute Cancer Research mice, resulting in hypertension, proteinuria, similar glomerular histological changes as those seen...
Preeclampsia is a pregnancy-specific syndrome characterized by elevated blood pressure, proteinuria, and intrauterine growth restriction (IUGR). Although sterile inflammation appears to be involved, its pathogenesis remains unclear. Recent evidence indicates that mediated through the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes, composed of NLRP3, apoptosis-associated speck-like protein containing caspase recruitment domain...
An extensive study as to whether maternal age itself is a risk factor for blood loss during parturition.A total of 10,053 consecutive women who delivered singleton infant were studied. The excess was defined separately with vaginal and cesarean deliveries > or = 90th centile value each delivery mode. effects 13 potential factors on analyzed using multivariate analysis.The 615 ml 1,531 deliveries, respectively. A low lying placenta (odds ratio [OR], 4.4), previous (3.1), operative (2.6),...
Problem Advanced glycation end products ( AGE s) and high‐mobility group box‐1 HMGB 1) are considered contributing to placental inflammation. We examined the effect of s 1 on cytokines from Sw.71 human trophoblast cell lines interactions between cells THP ‐1‐monocytes. Methods study were cultured with/without or 1. role migration IL ‐6 using co‐cultures conditioned medium ‐1 cells. Results increased interleukin (IL)‐6, ‐8, chemokine C‐C motif ligand 2 CCL 2) secretion The was dependent...