Sadayoshi Ito
A5066495888- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Renin-Angiotensin System Studies
- Renal and Vascular Pathologies
- Adrenal and Paraganglionic Tumors
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Nitric Oxide and Endothelin Effects
- Adrenal Hormones and Disorders
- Electrolyte and hormonal disorders
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Sodium Intake and Health
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Heart Rate Variability and Autonomic Control
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Peroxisome Proliferator-Activated Receptors
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
Tohoku University
2016-2025
Tohoku University Hospital
2014-2023
The University of Tokyo
1999-2022
Niigata University
1980-2022
Tohoku Medical Megabank Organization
2016-2021
Mamata General Hospital
2020
Center for Vascular Biology Research
2002-2019
Otto-von-Guericke University Magdeburg
2019
Nagoya City University
1995-2018
Japanese Society of Nephrology
2018
In this study, we defined the role of peroxisome proliferator-activated receptor β/δ (PPARδ) in metabolic homeostasis by using subtype selective agonists. Analysis rat L6 myotubes treated with PPARδ subtype-selective agonist, GW501516, Affymetrix oligonucleotide microarrays revealed that controls fatty acid oxidation regulating genes involved transport, β-oxidation, and mitochondrial respiration. Similar PPARδ-mediated gene activation was observed skeletal muscle GW501516-treated mice....
Microalbuminuria is an early predictor of diabetic nephropathy and premature cardiovascular disease. We investigated whether treatment with angiotensin-receptor blocker (ARB) would delay or prevent the occurrence microalbuminuria in patients type 2 diabetes normoalbuminuria.
Objective To compare the predictive powers of self-measurement blood pressure at home (home measurement) and casual (screening) measurement for mortality. Design A prospective cohort study. Subjects methods We obtained screening measurements 1789 subjects aged ≥ 40 years who were followed up a mean 6.6 years. The prognostic significance mortality was determined by Cox proportional hazards regression model adjusted age, sex, smoking status, past history cardiovascular disease, use...
Abstract —To investigate the association between cardiovascular mortality and short-term variabilities in blood pressure heart rate, we performed a long-term prospective study of ambulatory monitoring Ohasama, Japan, starting 1987. We obtained rate 1542 subjects ≥40 years age. Blood were estimated as standard deviation measured every 30 minutes by monitoring. There 67 deaths during follow-up period (mean=8.5 years). The Cox proportional hazards model, adjusted for possible confounding...
In this prospective, randomized, open-label, blinded end point study, we aimed to establish whether strict blood pressure control (<140 mm Hg) is superior moderate (≥140 Hg <150 in reducing cardiovascular mortality and morbidity elderly patients with isolated systolic hypertension. We divided 3260 aged 70 84 years hypertension (sitting 160 199 into 2 groups, according or treatment. A composite of events was evaluated for ≥2 years. The (1545 patients) (1534 groups were well matched...
Phaeochromocytomas (PHEO) and paragangliomas are rare catecholamine-producing tumours. Although 10-30% of these tumours metastasise, histopathological criteria to discriminate malignant from benign have not been established; therefore, reliable markers predicting metastasis urgently required. A total 163 tumours, including 40 metastatic collected by the Phaeochromocytoma Study Group in Japan (PHEO-J) were analysed using a system called grading for adrenal phaeochromocytoma paraganglioma...
Rationale & ObjectiveEpidemiologic and clinical studies have suggested that urate-lowering therapy may slow the progression of chronic kidney disease (CKD). However, definitive evidence is lacking.Study DesignRandomized, double-blind, placebo-controlled trial.Setting Participants467 patients with stage 3 CKD asymptomatic hyperuricemia at 55 medical institutions in Japan.InterventionParticipants were randomly assigned a 1:1 ratio to receive febuxostat or placebo for 108 weeks.OutcomesThe...
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave rise to devastating damage on the Pacific coast Tohoku region. Medical Megabank Project (TMM), which is being conducted by University Organization (ToMMo) Iwate (IMM), has been launched realize creative reconstruction solve medical problems in aftermath this disaster. We started two prospective cohort studies Miyagi Prefectures: a population-based adult study, TMM Community-Based Cohort Study (TMM CommCohort...
Diabetic kidney disease is a major cause of renal failure that urgently necessitates breakthrough in management. Here we show using untargeted metabolomics levels phenyl sulfate, gut microbiota-derived metabolite, increase with the progression diabetes rats overexpressing human uremic toxin transporter SLCO4C1 kidney, and are decreased limited proteinuria. In experimental models diabetes, sulfate administration induces albuminuria podocyte damage. diabetic patient cohort, significantly...
MDA5 is an essential intracellular sensor for several viruses, including picornaviruses, and elicits antiviral interferon (IFN) responses by recognizing viral dsRNAs. has been implicated in autoimmunity. However, the mechanisms of how contributes to autoimmunity remain unclear. Here we provide direct evidence that dysregulation caused autoimmune disorders. We established a mutant mouse line bearing mutation ENU mutagenesis, which spontaneously developed lupus-like symptoms without infection....
A significant link has been reported between aortic stiffening and renal microvascular damage, but the underlying mechanism remains poorly understood. We hypothesized that alterations in central hemodynamics are responsible for this link. In 133 patients with hypertension, pressure waveforms were recorded on radial, carotid, femoral, dorsalis pedis arteries applanation tonometry to estimate pressures (carotid-femoral) peripheral (carotid-radial femoral-dorsalis pedis) pulse wave velocities....
The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an converting enzyme inhibitor (ACEI). We examined the olmesartan, ARB, on primary composite outcome doubling serum creatinine, endstage disease death overt nephropathy. Secondary included outcomes, changes function proteinuria. Randomisation allocation to trial group were carried out by central computer system....
Gut microbiota is involved in the metabolism of uremic solutes. However, precise influence to retention solutes CKD obscure. To clarify this, we compared adenine-induced renal failure and control mice under germ-free or specific pathogen-free (SPF) conditions, examining metabolite profiles plasma, feces, urine using a capillary electrophoresis time-of-flight mass spectrometry-based approach. Mice with conditions demonstrated significant changes plasma metabolites. Among 183 detected solutes,...