A5033365237- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Biomedical Research and Pathophysiology
- Renal Diseases and Glomerulopathies
- Genetic Syndromes and Imprinting
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Ion Transport and Channel Regulation
- Liver Disease Diagnosis and Treatment
- Sodium Intake and Health
- Neuroscience and Neuropharmacology Research
- Animal Virus Infections Studies
- Diet and metabolism studies
- Viral Infections and Immunology Research
- Fetal and Pediatric Neurological Disorders
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Organ Donation and Transplantation
- Hedgehog Signaling Pathway Studies
- Pediatric Urology and Nephrology Studies
- Birth, Development, and Health
- Parathyroid Disorders and Treatments
- Nuclear Receptors and Signaling
Fujita Health University
2014-2025
Fujita Health University Hospital
1993-2021
Model Animal Research Center
1999-2017
University of Kansas Medical Center
1995-2010
University of Kansas
2003
Pennsylvania State University
2001
University Medical Center
1997-2000
Vanderbilt University
2000
Hokkaido Pharmaceutical University
1997
University Hospital and Clinics
1997
Diabetic kidney disease is a major cause of renal failure that urgently necessitates breakthrough in management. Here we show using untargeted metabolomics levels phenyl sulfate, gut microbiota-derived metabolite, increase with the progression diabetes rats overexpressing human uremic toxin transporter SLCO4C1 kidney, and are decreased limited proteinuria. In experimental models diabetes, sulfate administration induces albuminuria podocyte damage. diabetic patient cohort, significantly...
Renal enlargement in polycystic kidney disease (PKD) is caused by the proliferation of mural epithelial cells and transepithelial fluid secretion into cavities innumerable cysts. Arginine vasopressin (AVP) stimulates human PKD <i>in vitro via</i> cAMP-dependent activation B-Raf/MEK (MAPK/ERK kinase/extracellular signal–regulated kinase (ERK) pathway. ERK activity elevated that line cysts animals with PKD, AVP receptor antagonists reduce halt progression. For suppression effect...
Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited disease. Mutations in PKD1 and PKD2 genes, encoding polycystin 1 2 Ca2+ ion channels, respectively, result tubular epithelial cell-derived renal cysts. Recent clinical studies demonstrate oxidative stress to be present early ADPKD. Mitochondria comprise primary reactive oxygen species source also their main effector target; however, pathophysiological role of mitochondria ADPKD remains uncharacterized. To...
Estrogen is synthesized throughout various tissues in the body, and its production regulated by rate‐limiting enzyme aromatase (encoded Cyp19a1 gene). Notably, also expressed central nervous system cells, allowing for localized estrogen synthesis regions such as hypothalamus. Estrogens produced within these neurons are referred to neuroestrogens. In this study, we investigated role of neuroestrogens regulation appetite through modulation hypothalamic pathways OVX, ArKO, aromatase‐restored...
The programmed death-1 (PD-1)/B7-H1 pathway acts as an important negative regulator of immune responses. We herein investigated the role PD-1/B7-H1 in establishing immunological spontaneous tolerance status mouse liver allografting. B7-H1 is highly expressed on donor-derived tissue cells and it also associated with apoptosis infiltrating T allografts. Strikingly, a blockade via anti-B7-H1mAb or using knockout mice donor led to severe cell infiltration well hemorrhaging necrosis, thus...
In autosomal recessive polycystic kidney disease (ARPKD), progressive enlargement of fluid-filled cysts is due to aberrant proliferation tubule epithelial cells and transepithelial fluid secretion leading extensive nephron loss interstitial fibrosis. Congenital hepatic fibrosis associated with biliary cysts/dilatations the most common extrarenal manifestation in ARPKD can lead massive liver enlargement. Peroxisome proliferator-activated receptor γ (PPAR-γ), a member ligand-dependent nuclear...
The DBA/2FG-pcy mouse has a form of slowly progressive kidney disease that appears similar in many respects to seen the autosomal dominant human polycystic disease. aim this study was examine mRNA expression growth-related proteins obtained from mice and control DBA/2 at 8, 16, 30 wk age. levels encoding for proliferating cell nuclear antigen (PCNA), transforming growth factor (TGF)-beta, platelet-derived (PDGF)-A PDGF-B chains, insulin-like (IGF)-I, basic fibroblast (bFGF) were increased...
Glucose and insulin positively regulate glycolysis lipogenesis through the activation of carbohydrate response element-binding protein (ChREBP) sterol regulatory 1c (SREBP1c), but their respective roles in regulation gluconeogenic ureagenic genes remain unclear. We compared effects antagonist S961 Chrebp deletion on hepatic glycolytic, lipogenic, gluconeogenic, gene expression mice. markedly increased plasma glucose, insulin, 3-OH-butyrate concentrations reduced triglyceride content, had no...
Background: Hereditary cystic kidney diseases are ciliopathies characterized by functional defects in the primary cilia of renal tubules. Abnormalities enhance cell proliferation signals and cause cyst enlargement. The most common type is autosomal dominant polycystic disease (ADPKD), but other diseases, such as nephronophthisis, have been discovered to be more than previously considered. In ADPKD, several microRNAs reportedly aberrantly expressed involved pathogenesis. Among these, we...
In polycystic kidney disease (PKD), cyst lining cells show polarity abnormalities. Recent studies have demonstrated loss of cell contact in cells, suggesting induction epithelial-to-mesenchymal transition (EMT). Recently, EMT has been implicated the pathogenesis PKD. To explore further evidence PKD, we examined age- and segment-specific expression adhesion molecules mesenchymal markers PCK rats, an orthologous model human autosomal-recessive Kidneys from 5 male control rats each at 0 days,...
Here we examined whether the expression of a novel immunoregulatory gene set could be used to predict outcomes in murine models rapamycin-induced cardiac tolerance, spontaneous hepatic and rejection. The was assessed with GeXP multiplex reverse-transcription polymerase chain reaction (RT-PCR) analysis system, it correlated pathological biochemical parameters allografts. In rejecting grafts, increased an inflammatory genes, which included CD45, CD4, CD25, suppressor cytokine signaling 2,...
Uptake of P(i) at the cellular membrane is essential for maintenance cell viability. However, phosphate overload also stressful cells and can result in damage. In present study, we investigated effects transgenic overexpression type III transporter Pit-1 to explore role extracellular glomerular sclerosis during chronic renal disease. (TG) rats showed progressive proteinuria associated with hypoalbuminemia dyslipidemia. Ultrastructural analysis TG rat kidney by transmission electron...