A5066459722- Renal Transplantation Outcomes and Treatments
- Radioactive contamination and transfer
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Nuclear and radioactivity studies
- Renal Diseases and Glomerulopathies
- Transplantation: Methods and Outcomes
- Risk Perception and Management
- Radioactivity and Radon Measurements
- RNA Interference and Gene Delivery
- Renal and Vascular Pathologies
- Radiation Dose and Imaging
- Cytomegalovirus and herpesvirus research
- Metabolism and Genetic Disorders
- Neurological Complications and Syndromes
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Graphite, nuclear technology, radiation studies
- Radiation Detection and Scintillator Technologies
- Risk and Safety Analysis
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Fluid Dynamics and Vibration Analysis
- Organ and Tissue Transplantation Research
Japan Atomic Energy Agency
2016-2025
Niigata University
2001-2025
Japanese Red Cross Narita Hospital
2023
The University of Tokyo
2023
International University of Health and Welfare
2023
Osaka University
2010-2019
Kyoto University
1989-2018
Graduate School USA
2018
International Atomic Energy Agency
2013
The University of Kitakyushu
2013
A consensus meeting was held in Vienna on September 8–9, 2013, to discuss diagnostic and therapeutic challenges surrounding development of diabetes mellitus after transplantation. The International Expert Panel comprised 24 transplant nephrologists, surgeons, diabetologists clinical scientists, which met with the aim review previous guidelines light emerging data research. Recommendations from discussions are provided this article. Although kidney-centric, reflecting expertise present, these...
The programmed death-1 (PD-1)/B7-H1 pathway acts as an important negative regulator of immune responses. We herein investigated the role PD-1/B7-H1 in establishing immunological spontaneous tolerance status mouse liver allografting. B7-H1 is highly expressed on donor-derived tissue cells and it also associated with apoptosis infiltrating T allografts. Strikingly, a blockade via anti-B7-H1mAb or using knockout mice donor led to severe cell infiltration well hemorrhaging necrosis, thus...
Abstract A risk indicator that allows for the comparison of risks caused by different factors is highly useful enhancing public understanding. The International Commission on Radiological Protection developed concept “detriment” to quantify radiation-related health effects at low doses. However, detriment specific radiation field and cannot be simply compared with other risks. In this study, disability-adjusted life years (DALYs), lifetime incidence risk, mortality due exposure were among 33...
Abstract Public living in areas contaminated by nuclear accidents is exposed to radiation the early phase and over long term. Even under similar accident scenarios, doses sheltering effectiveness, which one of protective measures, depend on meteorological conditions surrounding environment. Radiation effectiveness are crucial information for public as well national local governments planning a emergency preparedness. In this study, we assessed at sites with facilities Japan using Off-Site...
Regenerative endodontic procedures using blood clots (BC-REP) for immature teeth typically exhibit a periodontal ligament–like healing pattern. However, pulp-like pattern is observed in the presence of residual pulp. This study aimed to clarify phenotype according tooth maturity when performing BC-REP pulp, focusing on migrated mesenchymal stem/stromal cells (MSCs). rat molar models were created pulp at ages corresponding developmental stages, from mature (5 wk: immature, root still growing;...
Erythropoietin (EPO), a member of the cytokine type I superfamily, acts to increase circulating erythrocytes primarily by preventing apoptosis erythroid progenitors, is known protect tissues and can raise haemoglobin (Hb) concentrations. Recently, second receptor for EPO comprising beta-common has been reported mediate EPO-induced tissue protection. modified carbamylation (CEPO) only signals through this receptor. Accordingly, we hypothesized that treatment with CEPO, which would not Hb...
We have reported that B6.CCR5(-/-) mice reject renal allografts with high serum donor-specific antibody (DSA) titers and marked C4d deposition in grafts, features consistent antibody-mediated rejection (AMR). B6.huCD20/CCR5(-/-) mice, where human CD20 expression is restricted to B cells, rejected A/J by day 26 posttransplant DSA first detected on 5 increased thereafter. Recipient treatment anti-huCD20 mAb prior the transplant weekly up 7 weeks promoted long-term allograft survival (>100...
Tube arrays in cross flow start to vibrate abruptly when the reaches at a certain velocity. The threshold velocity depends upon geometrical arrangement of tubes. It is very important for practical applications understand relations between and pitch-to-diameter ratio tube array. Unsteady fluid dynamic forces on array with 2.0 were clarified experimentally characteristics revealed by calculating unsteady forces. By comparing velocities 1.33, respect clarified.
The ultimate goal of organ transplantation is to establish graft tolerance where CD4+CD25+FOXP3+ regulatory T (Treg) cells play an important role. We examined whether a superagonistic monoclonal antibody specific for CD28 (CD28 SA), which expands Treg in vivo, would prevent acute rejection and induce using our established rat renal allograft model (Wistar Lewis). In the untreated or mouse IgG-treated recipients, function significantly deteriorated with marked destruction tissue, all rats...
This investigation was conducted to determine whether renal transplantation can improve sexual function in male patients with chronic failure. The authors retrospectively studied 121 men undergoing who complained of any type or degree dysfunction pre-operatively. Sexual evaluated by questionnaire which included erectile, ejaculative, and orgasmic functions. Pre- postoperative frequency intercourse also recorded. Patient characteristics, laboratory data, endocrinologic profiles were analyzed...